A5035130926- Psoriasis: Treatment and Pathogenesis
- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- COVID-19 Clinical Research Studies
- Musculoskeletal pain and rehabilitation
- Dermatology and Skin Diseases
- Monoclonal and Polyclonal Antibodies Research
- Bone Metabolism and Diseases
- SARS-CoV-2 and COVID-19 Research
- Asthma and respiratory diseases
- Sulfur Compounds in Biology
- Cytokine Signaling Pathways and Interactions
- Biosimilars and Bioanalytical Methods
- Fibroblast Growth Factor Research
- CAR-T cell therapy research
- Research on Leishmaniasis Studies
- Vaccine Coverage and Hesitancy
- Pain Mechanisms and Treatments
- Pain Management and Placebo Effect
- Macrophage Migration Inhibitory Factor
- Retinoids in leukemia and cellular processes
- Ocular Diseases and Behçet’s Syndrome
University of Glasgow
2020-2025
Institute of Infection and Immunity
2022
Institut Toulousain des Maladies Infectieuses et Inflammatoires
2021
University of Rome Tor Vergata
2015-2020
Sapienza University of Rome
2016
Currently, there is a growing interest in Janus kinase (JAK) intracellular signalling since targeted inhibitors against these pathways are proving effective the treatment of range immune-mediated diseases, such as rheumatoid arthritis (RA), psoriasis, psoriatic (PsA), inflammatory bowel disease and atopic dermatitis. In particular, post marketing experience increasing development new pharmacological broad increasingly selective JAK provide insights into pathway role viral infections well...
BackgroundThe humoral and T-cell responses to booster COVID-19 vaccine types in multidisease immunocompromised individuals who do not generate adequate antibody two doses, is fully understood. The OCTAVE DUO trial aimed determine the value of third vaccinations a wide range patients with primary secondary immunodeficiencies.MethodsOCTAVE-DUO was prospective, open-label, multicentre, randomised, controlled, phase 3 investigating are following dose BNT162b2 or mRNA-1273, NVX-CoV2373 for those...
Background Secukinumab (SEC) is effective for ankylosing spondylitis (AS) and psoriatic arthritis (PsA) in randomized trials, but real-life data are lacking.Research design methods Real-life, prospective observational study on 169 consecutive outpatients at baseline (T0) 6 (T6) 12 months (T12) after starting SEC (39 AS, 23%; 130 PsA, 77%).Results Significant improvement was seen T6 T12 all clinical variables, including TJC, SJC, ESR, CRP, DAPSA, ASDAS-CRP, BASDAI, as well patient-reported...
Abstract Background Pain remains a principal complaint for people with psoriatic arthritis (PsA), despite successful mitigation of inflammation. This situation alludes to the co-existence distinct pain mechanisms. Nociceptive and nociplastic mechanisms are clinically challenging distinguish. Advances in brain functional magnetic resonance imaging (fMRI) have successfully characterised across several disorders, particular implicating insula. is first study characterise neurobiological markers...
To assess the involvement of CCR6/CCL20 axis in psoriatic arthritis (PsA) and psoriasis (PsO) to evaluate its potential as a therapeutic target.First, we quantified CCL20 levels peripheral blood synovial fluid from PsA patients examined presence CCR6+ cells tendon tissue. Utilizing an interleukin-23 minicircle DNA (IL-23 MC) mouse model exhibiting key features both PsO PsA, investigated CCR6 expression well preventive effect blockade. Healthy stromal were stimulated vitro with IL-1β...
Objectives Circulating myeloid precursors are responsible for post-natal osteoclast (OC) differentiation and skeletal health, although the exact human have not been defined. Enhanced osteoclastogenesis contributes to joint destruction in rheumatoid arthritis (RA) tumour necrosis factor (TNF) is a well-known pro-osteoclastogenic factor. Herein, we investigated interplay between receptor activator of nuclear kappa-Β ligand (RANK-L), indispensable fusion normal development OCs, TNF directing...
This retrospective study used various indices to evaluate remission and low disease activity in 'real life' patients with rheumatoid arthritis (RA), given antitumour necrosis factor (anti-TNF) as a first-line treatment; changes concomitant steroid conventional synthetic disease-modifying antirheumatic drug (csDMARD) treatment were also assessed.Remission analysed RA treated anti-TNF using the 28-joint Disease Activity Score (DAS28), Simplified Index (SDAI) Clinical (CDAI). Remission recorded...
Abstract Objectives Psoriatic arthritis (PsA) is associated with bone erosion and inflammation-induced loss, which are mediated by osteoclasts (OC) modulated inflammatory cytokines. Apremilast (APR) (a selective phosphodiesterase 4 inhibitor) efficacious in PsA acts inhibiting cytokine production. However, there no direct data informing whether how APR affects osteoclast formation humans. Methods Osteoclastogenic production activated human peripheral blood mononuclear cells (PBMCs) was...
Abstract Background/Aims Psoriatic Arthritis (PsA) is an inflammatory arthritis with enthesitis as its characteristic clinical feature. Enthesitis can be clinically challenging to differentiate from the widespread pain associated Fibromyalgia (FM), prototype of central sensitisation (CS) present in up 30% PsA patients. Algometry used CS research quantify pressure threshold (PPT), reflecting increased sensitivity when reduced. Ultrasound a valuable tool evidence entheseal changes PsA. This...
<h3>Background:</h3> Multiple mechanisms underly the major burden of rheumatoid arthritis (RA) pain. The high prevalence co-existing fibromyalgia (FM) supports contribution central nervous system associated nociplastic pain pathways. In RA, we previously employed functional MRI (fMRI) brain to objectively demonstrate (hyperconnectivity between Default Mode Network [DMN] and Insula). addition, among those with FM, observed a significant relationship peripheral inflammation hyperconnectivity,...
Patients with the musculoskeletal disorder psoriatic arthritis improve their inflammation current treatments but still experience pain. Previous neuroimaging findings have identified functional connectivity of resting-state default mode network and we explored how such features associate nociplastic pain using both agonistic selective approaches. We observed increased between regions brain related to intensity decreased inhibition. The implications shift focus onto targeting central pathways...
<h3>Background</h3> Remission or low disease activity (LDA) are the main treatment targets in Rheumatoid Arthritis (RA). Different remission criteria have been developed and differ between studies. The advent of biologic disease-modifying antirheumatic drugs (DMARDs) allowed a proportion patients to reach these goals. <h3>Objectives</h3> We aimed at evaluating remission, sustained LDA "real life" RA treated with first line anti-TNF agents by different criteria. evaluated concomitant...