A5021018941- Inflammatory Bowel Disease
- Liver Disease Diagnosis and Treatment
- Microscopic Colitis
- Ultrasound and Hyperthermia Applications
- Ultrasound Imaging and Elastography
- Pancreatic and Hepatic Oncology Research
- Viral gastroenteritis research and epidemiology
- Pancreatitis Pathology and Treatment
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Diverticular Disease and Complications
- Sports injuries and prevention
- Hepatocellular Carcinoma Treatment and Prognosis
- Ultrasound in Clinical Applications
- Celiac Disease Research and Management
- Neuroendocrine Tumor Research Advances
- Liver Diseases and Immunity
- Spectroscopy Techniques in Biomedical and Chemical Research
- Immune cells in cancer
- Gastrointestinal disorders and treatments
- Clinical Nutrition and Gastroenterology
- Colorectal Cancer Treatments and Studies
- IgG4-Related and Inflammatory Diseases
- Lower Extremity Biomechanics and Pathologies
- Skin Diseases and Diabetes
Friedrich-Alexander-Universität Erlangen-Nürnberg
2012-2023
Universitätsklinikum Erlangen
2013-2023
Abstract Ductal occlusion has been postulated to precipitate focal pancreatic inflammation, while the nature of primary occluding agents remained elusive. Neutrophils make use histone citrullination by peptidyl arginine deiminase-4 (PADI4) in contact particulate extrude decondensed chromatin as neutrophil extracellular traps (NETs). In high cellular density, NETs form macroscopically visible aggregates. Here we show that such aggregates inside ducts humans and mice thereby driving...
In a prospective study, we compared the different perfusion kinetics of HCC and ICC using dynamic contrast-enhanced ultrasound (DCE-US).Patients with proven were included. Three-minute video clips CEUS examinations (CPS - low MI mode) after bolus injection 1.2 ml SonoVue recorded analyzed quantification software (VueBox). Parameters for arterial contrast enhancement [rise time (RT), time-to-peak (TTP)] towards portal venous [mean transit (local) (mTTl) fall (FT)] quantified. Furthermore,...
<b>Background and study aim:</b> The differential diagnosis of ulcerative colitis from Crohn's disease is pivotal importance for the management inflammatory bowel diseases, as both entities involve specific therapeutic strategies. Confocal laser endomicroscopy (CLE) allows on-demand, in vivo characterization architectural cellular details during endoscopy. aim this was to assess efficacy CLE differentiate between disease. <b>Patients methods:</b> This a prospective involving consecutive...
To explore the impact of cholestasis on liver stiffness assessed by acoustic radiation force impulse (ARFI) technology.Over a period four months, patients with sonographic and increased cholestatic blood values (Bilirubin, γGT, AP > 2 times ULN) scheduled for endoscopic therapy were recruited. Exclusion criteria were: known disease; signs cirrhosis at ultrasound (irregular veins and/or surface); heart insufficiency (NYHA III-VI). ARFI (Siemens S2000), examinations performed before in...
Background. Acoustic radiation force impulse (ARFI) elastometry quantifies hepatic stiffness, and thus degree of fibrosis, non-invasively. Our aim was to analyse the diagnostic accuracy ARFI cut-off values, significance a defined limit standard deviation (SD) as potential quality parameter for liver fibrosis staging in patients with chronic diseases (CLD). Material methods. 153 CLD (various aetiologies) undergoing biopsy, an additional 25 known cirrhosis, were investigated. measurements...
To emphasize the diagnostic value of contrast-enhanced ultrasound (CEUS) in imaging muscle injuries with different degrees severity by comparing findings to established modalities such as conventional and magnetic resonance (MRI).Case series.Institutional study. Conventional CEUS were performed Department Internal Medicine. Magnetic was carried out Radiology within Magnetom Avanto 1.5T Skyra fit 3T (Siemens Healthineers, Erlangen, Germany) Institution Imaging Diagnostics Therapy (Magnetom...
Delayed onset muscle soreness is one of the most common reasons for impaired performance in sports and associated with reduced strength frequently observed both professional recreational athletes.To emphasize diagnostic value acoustic radiation force impulse (ARFI) imaging delayed by comparing findings high-resolution 3T magnetic resonance T2-weighted sequences.Case series.Laboratory environment.Fifteen healthy students (7 females 8 males; mean [SD]: age 24 [4] y, height 178 [10] cm, body...
In the work-up of focal pancreatic lesions autoimmune pancreatitis (AIP) is a rare differential diagnosis to cancer (PC) with similar clinical constellations. The aim our study was compare differences between proven AIP and PC using transabdominal dynamic contrast enhanced ultrasound (DCE-US). Therefore we recorded 3-minute-clips CEUS examinations analyzed perfusion parameters VueBox<sup>®</sup>-quantification software. To obtain DCE-US Parameters, Regions-of-Interest were selected within...
The purpose of this study was to analyse intramuscular perfusion response in ultrastructural muscle lesions, by applying contrast-enhanced ultrasound (CEUS) a delayed onset soreness (DOMS) model. Results analysis were compared high-resolution 3 Tesla MRI T2-weighted sequences. 14 healthy participants recruited. Average parameters, represented as Peak enhancement (contrast agent inflow) and wash-in area under curve (WiAUC) the gastrocnemius (GM) soleus (SM) assessed before (baseline) 60 h...
Ultrasound is a well-established noninvasive test for assessing patients with liver disease. This study aims to prospectively compare ultrasound the new technique elastography (ARFI) assessment of fibrosis/cirrhosis.High-frequency B-mode (liver surface/vein irregularity, homogeneity, spleen size), ARFI quantification, mini-laparoscopic evaluation including biopsy were obtained in compensated scheduled biopsy. For diagnosis cirrhosis, combined gold standard (cirrhosis at histology and/or...
Acoustic Radiation Force Impulse (ARFI) elastography evaluates hepatic fibrosis non-invasively and has been mainly validated in viral hepatitis. Data on rare liver diseases such as autoimmune hepatitis (AIH), overlap syndrome, primary biliary cholangitis (PBC) or sclerosing (PSC) are sparse.
Objectives Two-dimensional shear-wave elastography (2D-SWE) is an ultrasound-based technique for the noninvasive assessment of tissue stiffness. In contrast to well-established point-shear-wave (pSWE) method acoustic radiation force impulse imaging, there little evidence on performance and usefulness 2D-SWE in liver Thus, aim our study was compare versus pSWE. Materials methods pSWE were performed 20 cirrhotic patients, healthy individuals elasticity phantom. Stiffness values, examination...
Background Microvascularization of the bowel wall can be visualized and quantified non-invasively by software-assisted analysis derived time-intensity curves. Purpose To perform software-based quantification perfusion using quantitative contrast-enhanced ultrasound (CEUS) according to clinical response in patients with inflammatory disease treated vedolizumab. Material Methods In a prospective study, 18 out 34 patients, high-frequency thickness color Doppler flow combined CEUS was performed...
Acoustic radiation force impulse (ARFI) elastography is a non-invasive, ultrasound-based approach of evaluation tissue elasticity. It has not yet been systematically applied to the bowel wall.To perform ARFI wall in healthy volunteers and patients with ulcerative colitis (UC).A high-frequency ultrasound (with thickness vascularization score) an were performed 20 UC 13 volunteers. At least 10 measurements obtained within terminal ileum ascending, transverse, descending, sigmoid colon...
<b>Purpose:</b> Sonographically guided interventions in abdominal organs are routine procedures with rare severe complications. However, potential patient discomfort or pain is frequently not addressed the literature. <b>Materials and Methods:</b> In a prospective 1-year study, peri- postinterventional of patients undergoing sonographically punctures liver pancreas was analyzed. Data acquisition done standardized questionnaire. This included three numeric rating scales (NRS) ranging from “0”...
Endosonography (EUS) is one of the main diagnostic tools for differential diagnosis pancreatic masses. The aim our study was to describe value this technique in work-up solid lesions, considering influence morphological evidence inflammation process.Retrospective analysis prospectively collected data tertiary University center. From March 2007 October 2015, 218 patients underwent EUS a suspected neoplasm (based on previous cross-sectional imaging results, idiopatic acute pancreatitis, weight...
<b>Purpose:</b> The aim of this study was to evaluate whether acoustic radiation force impulse (ARFI) elastography done with the 4C1 probe yields comparable results recently introduced 6C1HD probe. <b>Materials and Methods:</b> Measurements probes (Acuson S2000) were performed compared in four different inclusions an elasticity phantom model (QA049 CIRS) as well liver healthy individuals patients cirrhosis. <b>Results:</b> slightly higher all (8, 14, 45, 80kPA) a mean 1.48 m/s (95 %-CI; 1.47...
Problemstellung: Studien haben gezeigt, dass die Elastografie von rechts-interkostaler gute Ergebnisse hinsichtlich der Fibrose-/Zirrhosebeurteilung aufweist. Diese Arbeit soll mögliche Einflussfaktoren auf Messungen Scherwellengeschwindigkeit untersuchen. Patienten und Methode: Für verschiedenen potentiellen wurden jeweils 10 durch einen rechten Interkostalraum (ICR) in mittleren Axillarlinie bei gesunden Zirrhosepatienten vorgenommen (6C1-Schallkopf, Acuson S2000). Im ICR (zwischen den...