A5009134320- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Systemic Sclerosis and Related Diseases
- Vasculitis and related conditions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Lipoproteins and Cardiovascular Health
- Inflammatory Bowel Disease
- Inflammasome and immune disorders
- Lipid metabolism and disorders
- Liver Disease Diagnosis and Treatment
- Complement system in diseases
- Cytokine Signaling Pathways and Interactions
- Ocular Diseases and Behçet’s Syndrome
- Hepatitis C virus research
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes and associated disorders
- Bone and Joint Diseases
- Sarcoidosis and Beryllium Toxicity Research
- Retinal and Optic Conditions
- Otitis Media and Relapsing Polychondritis
- Chronic Lymphocytic Leukemia Research
Hospital Universitario de Canarias
2016-2025
Universidad de La Laguna
2013-2025
Universidad de Cantabria
2014-2023
Instituto de Investigación Marqués de Valdecilla
2014-2023
Center for Rheumatology
2016-2017
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2014
Sociedad Española de Reumatología
2013-2014
A single family has been described in which obesity results from a mutation the leptin-receptor gene (LEPR), but prevalence of such mutations severe, early-onset not systematically examined.We sequenced LEPR 300 subjects with hyperphagia and severe obesity, including 90 probands consanguineous families, investigated extent to cosegregated affected receptor function. We evaluated metabolic, endocrine, immune function relatives.Of subjects, 8 (3%) had nonsense or missense mutations--7 were...
Objectives. The aims of this study were to physical activity (PA) in patients with RA by accelerometry and determine what degree their mobility is affected disease activity. Methods. A group 50 patients, without lower limb clinical disease, age- sex-matched healthy controls included cross-sectional study. PA was assessed the International Physical Activity Questionnaire (IPAQ). We performed multiple regression analysis not only compare between groups, but also explore relation features,...
Abstract Cardiovascular (CV) disease is the main cause of mortality in axial spondyloarthritis (axSpA). CV risk enhanced by dysregulation adipokines. Low omentin levels were associated with metabolic dysfunction and conditions different from axSpA. Accordingly, we evaluated genetic functional implication subclinical atherosclerosis a cohort 385 axSpA patients. Subclinical was carotid ultrasound. Omentin rs12409609, linkage disequilibrium polymorphism risk, genotyped patients 84 controls....
The aim of this study was to determine the role endothelin-1 (ET-1), a molecule involved in multiple vascular and fibrosing abnormalities, as biomarker interstitial lung disease (ILD), well its use for differential diagnosis between idiopathic pulmonary fibrosis (IPF) ILD associated with autoimmune diseases (AD-ILD), using large well-defined cohort patients ILD. A total 112 IPF, 91 AD-ILD (28 rheumatoid arthritis (RA), 26 systemic sclerosis, 20 inflammatory myositis 17 pneumonia features) 44...
Lipid profiles appear to be altered in SLE patients due disease activity and inflammation. Cholesterol efflux capacity (CEC) is the ability of high-density lipoprotein cholesterol accept from macrophages. CEC has been linked cardiovascular events general population impaired patients. The aim this study was establish whether related subclinical carotid atherosclerosis patients.The present report a cross-sectional that encompassed 418 individuals: 195 223 controls. CEC, using an vitro assay,...
Introduction: Early diagnosis of interstitial lung disease (ILD) associated with rheumatoid arthritis (RA) constitutes a challenge for the clinicians. Pulmonary vasculopathy is relevant in development disease. Accordingly, we aimed to explore role vascular cell adhesion molecule-1 (VCAM-1), monocyte chemoattractant protein-1 (MCP-1) and asymmetric dimethylarginine (ADMA), key molecules vasculopathy, as potential biomarkers pulmonary fibrosis RA-ILD + . Methods: We included 21 patients two...
Objective To assess the predictive value of four cardiovascular (CV) risk algorithms for identifying high-risk psoriatic arthritis (PsA) patients. Methods Evaluation patients with PsA enrolled in Spanish prospective project CARdiovascular RheuMAtology. Baseline data 669 no history CV events at baseline visit, who were followed rheumatology outpatient clinics tertiary centres 7.5 years, retrospectively analysed to test performance Systematic Coronary Risk Assessment (SCORE), modified version...
Tocilizumab (TCZ) has demonstrated potential efficacy in managing large-vessel (LV) vasculitis such as giant-cell arteritis (GCA) and Takayasu (TAK). Despite the shared characteristics between LV-GCA phenotype TAK, there are differences both entities that may affect therapeutic responses to TCZ. We aim assess compare effectiveness safety of TCZ patients with TAK. Multicenter, observational study on 70 57 TAK treated Outcomes were assessed at baseline 1, 3, 6 12 months post-treatment...
Background Tocilizumab (TCZ) is a monoclonal antibody that neutralizes interleukin (IL)-6 and indicated for diseases characterized by markedly elevated inflammatory markers, such as rheumatoid arthritis (RA). The complement system has been implicated in the etiopathogenesis of RA. Objective To evaluate effect systemic IL-6 inhibition on pathways functional activity RA patients treated with TCZ. Desing Prospective non-interventional study. Methods Twenty-seven included TOCRIVAR study who...
Patients with rheumatoid arthritis (RA) have an increased risk of infections. This may be linked to disease-related factors, immunosuppressive therapy and the presence comorbidities. Background/Objectives: In unselected group RA patients, our aims were assess following: (a) incidence (b) features diseases (c) predictive factors severe respiratory infection (SRI). Methods: An observational retrospective study all patients included in vaccination program hospital between October 2011 2018 was...
Background: Soluble cell adhesion molecules such as sICAM-1 (soluble intercellular molecule-1), sVCAM-1 vascular and P-selectin have been implicated in cardiovascular disease pathogenesis the general population. Cardiovascular is prevalent among patients with systemic sclerosis (SSc). This study aims to investigate potential associations between serum levels of these specific comorbidities SSc patients. Methods: cross-sectional encompassed 81 individuals SSc. All underwent a complete...
To evaluate the predictive value of metabolic score for insulin resistance (METS-IR) in identifying patients with psoriatic arthritis (PsA) at high risk cardiovascular (CV) events. Assessment PsA enrolled Spanish prospective CARdiovascular ReuMAtology (CARMA) project. Baseline data from 500 without a history CV events, chronic kidney disease, diabetes mellitus or statin use baseline visit were analysed. Patients prospectively followed 10 years rheumatology outpatient clinics tertiary...
Systemic sclerosis (SSc) is a chronic multisystem disease characterised by microcirculatory vascular dysfunction and progressive fibrosis of the skin internal organs. Neutrophil gelatinase-associated lipocalin (NGAL) protein primarily secreted immune cells known to be elevated in inflammatory states. Our study aims investigate whether serum NGAL levels differ between individuals with SSc healthy controls, explore its relationship comprehensive characterisation features patients. A...