A5023448686- Inflammatory Bowel Disease
- Microscopic Colitis
- Pancreatitis Pathology and Treatment
- Immunodeficiency and Autoimmune Disorders
- Liver Disease Diagnosis and Treatment
- Pregnancy and Medication Impact
- Autoimmune and Inflammatory Disorders
- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Eosinophilic Esophagitis
- Systemic Lupus Erythematosus Research
- Genetic factors in colorectal cancer
- Health, psychology, and well-being
- Adolescent and Pediatric Healthcare
- Appendicitis Diagnosis and Management
- Rheumatoid Arthritis Research and Therapies
- Pediatric Hepatobiliary Diseases and Treatments
- Colorectal and Anal Carcinomas
- Intestinal Malrotation and Obstruction Disorders
- Hepatitis B Virus Studies
- Reproductive biology and impacts on aquatic species
- Psoriasis: Treatment and Pathogenesis
- IL-33, ST2, and ILC Pathways
Hospital General Universitario de Alicante Doctor Balmis
2016-2025
Instituto de investigación sanitaria y biomédica de Alicante
2022-2024
Instituto de Acuicultura Torre de la Sal
2023
Centro de Investigación Biomédica en Red
2022
Hospital Clínico Universitario de Valencia
2016
Universitat de València
2016
Shaare Zedek Medical Center
2016
Catholic University of Daegu
2016
Hospital Clínico Universitario Lozano Blesa
2015
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2013
OBJECTIVES: Although aggressive fluid therapy during the first days of hospitalization is recommended by most guidelines and reviews on acute pancreatitis (AP), this recommendation not supported any direct evidence. We aimed to evaluate association between amount administered initial 24 h incidence organ failure (OF), local complications, mortality. METHODS: This was a prospective cohort study. included consecutive adult patients admitted with AP. Local complications OF were defined...
Objective Psychological factors, such as stress, anxiety, and depression, are frequently related to inflammatory bowel disease (IBD). However, few studies have examined these factors in patients newly diagnosed with IBD. The aim of the present study was test psychological burden a recent diagnosis IBD this burden. Methods We performed prospective, multi-center, observational new (≤6 months). were recruited from four different Spanish hospitals. Clinical demographic characteristics collected....
Abstract Background Female gender could be a cause of diagnostic delay in inflammatory bowel disease (IBD). The aim this study was to investigate the women vs men and potential causes. Methods This multicenter cohort included 190 patients with recent diagnosis IBD (disease duration <7 months). Reconstruction clinical presentation process carried out conjunction semistructured patient interview, review, electronic medical records. Results median time from symptom onset longer than men:...
The development of albuminuria in diabetics is closely associated with an enhanced risk renal and cardiovascular disease. However, the role pathogenesis these clinical conditions remains controversial. Whether simply a biomarker or qualifies as surrogate endpoint for cardiorenal disease has wide-ranging implications from monitoring treatment patients to design trials drug development. We critically review available data determine whether association between causative. Current evidence...
Abstract Background Carrying the HLA-DQA1*05 gene has been linked to a higher risk of developing immunogenicity in patients with inflammatory bowel disease (IBD) who are treated tumor necrosis factor-alpha (TNF-a) inhibitors. However, studies have shown inconsistent evidence regarding its connection loss response or adverse events IBD. The aim is determine impact carriage allele on effectiveness, drug persistence and safety diagnosed IBD had received antiTNF-a Methods Retrospective,...
Abstract Background and Aims Primary sclerosing cholangitis [PSC] is usually associated with inflammatory bowel disease [IBD]. An increased risk of malignancies, mainly colorectal cancer [CRC] cholangiocarcinoma [CCA], has been reported in PSC-IBD patients. Our aim was to determine the clinical characteristics management PSC IBD patients, factors malignancies. Methods patients were identified from Spanish ENEIDA registry GETECCU. Additional data collected using AEG-REDCap electronic capture...
Blood translocation of bacterial-DNA has been described in patients with Crohn's disease (CD). The host's immune cell types cooperate to respond against bacterial insults. Some antimicrobial peptides are inducible after culture products and a linkage established between them NOD2/CARD15. aim was test whether defensins cathelicidin (LL-37) expression NOD2/CARD15 mutations blood neutrophils related molecular events CD patients. Fifty consecutively admitted 15 healthy controls were included....
We aimed at evaluating bacterial DNA (bactDNA) presence in blood of Crohn's disease (CD) patients remission as an independent risk factor flare 6 months.This is a prospective, multicenter study on CD with activity index (CDAI)<150. The primary end point was time-to-relapse evaluated by CDAI>150 the following months. BactDNA blood, nucleotide-binding oligomerization domain containing 2 (NOD2) genotype, and serum cytokine levels were determined baseline.A total 288 included. detected 98...
To evaluate the real-world effectiveness of golimumab in ulcerative colitis (UC) and to identify predictors response. METHODSWe conducted an observational, prospective multi-
The circumstances that determine how acute pancreatitis (AP) becomes severe are unknown. Differences in cytokine genetic encoding may the severity or influence etiology of AP. This article investigates relationship between different polymorphisms tumor necrosis factor alpha (TNF-alpha), interleukin 1 (IL-1), IL-1 receptor antagonist, IL-6, and IL-10 with AP serum levels encoded.Patients were included prospectively. Severity disease was determined according to Atlanta classification. Serum...
Abstract Background/Aims: Surveillance programmes (SPs) for hepatocellular carcinoma (HCC) in patients with cirrhosis intend to diagnose the tumour its early stages when an effective therapy can be applied. The aims of this study have been compare survival HCC being diagnosed or not SPs, and establish a more accurate profile best target population. Methods: From January 1996 June 2005, 290 were included. relationship between SP has analysed univariate analysis. Pretreatment variables found...
i] To evaluate the evolution of pregnancies and offspring after inflammatory bowel disease [IBD] surgery during pregnancy; ii] to describe indications, surgical techniques, frequency caesarean section concomitant with surgery.Patients operated on due IBD pregnancy 1998 were included. Participating clinicians asked review their databases identify cases. Data patients' demographics, characteristics, medical treatments, activity, outcomes, surgery, delivery, foetal maternal recorded.In all, 44...
Objective: To evaluate the effectiveness and safety of combination granulocyte–monocyte apheresis (GMA) after loss response (LOR) to anti-tumor necrosis factor (TNF) agents in ulcerative colitis (UC).Materials methods: A retrospective, multicenter study was performed 11 inflammatory bowel disease (IBD) Units. Clinical remission defined as a partial Mayo score ≤2. The treatment evaluated by rate anti-TNF intensification, switch, swap or colectomy.Results: Forty-seven patients with were...
To assess the effectiveness and safety of combining granulocyte-monocyte apheresis (GMA) vedolizumab (VDZ) in patients with refractory ulcerative colitis (UC).This retrospective, multicentre pilot study included all UC receiving both GMA VDZ. We recorded data on sessions, demographic characteristics, clinical response. Effectiveness was assessed 1 6 months after finishing using partial Mayo score, C-reactive protein, fecal calprotectin levels. Data were also compiled VDZ intensification, use...
Abstract: Purpose: Some new staging systems in hepatocellular carcinoma (HCC) have been described the last years. The aim of this study was to compare survival‐predicting capacity some variables and prognostic classifications. Methods: Demographic, clinical, analytical tumour characteristics were collected a including 115 patients with HCC. Predictors survival identified using Kaplan–Meier test Cox model. Comparison between different carried out. Results: 1‐, 2‐ 3‐year estimated 65%, 45%...
(1) Background: Stress, anxiety, and depression have been identified as factors that influence the development of inflammatory bowel disease (IBD). The main aim this study was to test effectiveness group multicomponent cognitive-behavioral therapy at reducing stress, depression, improving quality life clinical course disease. (2) Methods: A total 120 patients were evaluated using General Perceived Stress Scale, Scale by Disease, anxiety scale, questionnaire for with IBD. Disease activity...