A5049860476- Phytochemicals and Antioxidant Activities
- Gut microbiota and health
- Diet and metabolism studies
- Microbial Metabolites in Food Biotechnology
- Curcumin's Biomedical Applications
- X-ray Diffraction in Crystallography
- Microplastics and Plastic Pollution
- Crystallization and Solubility Studies
- Food composition and properties
- Protein Hydrolysis and Bioactive Peptides
- Probiotics and Fermented Foods
- Proteins in Food Systems
- Biochemical Analysis and Sensing Techniques
- Synthesis and Characterization of Heterocyclic Compounds
- Multicomponent Synthesis of Heterocycles
- Natural Antidiabetic Agents Studies
- Diet, Metabolism, and Disease
- Consumer Attitudes and Food Labeling
- Antioxidant Activity and Oxidative Stress
- Synthesis and Characterization of Pyrroles
- Polysaccharides and Plant Cell Walls
- Phytoestrogen effects and research
- Tea Polyphenols and Effects
- Clostridium difficile and Clostridium perfringens research
- Pomegranate: compositions and health benefits
Ghent University
2015-2024
Eurogentec (Belgium)
2024
Ghent University Hospital
2012-2023
VIB-UGent Center for Medical Biotechnology
2017
Bioscience Research
2017
Unité de Nutrition Humaine
2015
Abstract The management of the dysbiosed gut microbiota in inflammatory bowel diseases (IBD) is gaining more attention as a novel target to control this disease. Probiotic treatment with butyrate-producing bacteria has therapeutic potential since these are depleted IBD patients and butyrate beneficial effects on epithelial barrier function overall health. However, studies assessing effect probiotic supplementation microbe-microbe host-microbe interactions rare. In study, (three mono-species...
ABSTRACT Dynamic, multicompartment in vitro gastrointestinal simulators are often used to monitor gut microbial dynamics and activity. These reactors need harbor a community that is stable upon inoculation, colon region specific, relevant vivo conditions. Together with the reproducibility of colonization process, these criteria overlooked when modulatory properties from different treatments compared. We therefore investigated process two identical human intestinal ecosystem (SHIME),...
In this study, the prebiotic potential of arabinoxylan oligosaccharides (AXOS) was compared with inulin in two simulators human intestinal microbial ecosystem. Microbial breakdown both and short-chain fatty acid production colon compartment specific, ascending transverse being predominant site AXOS degradation, respectively. Lactate levels (+5.5 mM) increased during supplementation, while propionate (+5.1 colon. The concomitant decrease lactate suggests that partially formed over acrylate...
Arabinoxylan-oligosaccharides (AXOS) are a recently newly discovered class of candidate prebiotics as - depending on their structure they fermented in different regions gastrointestinal tract. This can have an impact the protein/carbohydrate fermentation balance large intestine and, thus, affect generation potentially toxic metabolites colon originating from proteolytic activity. In this study, we screened AXOS preparations for vitro intestinal activity and microbial community structure....
Abstract To control and enhance protein functionality is a major challenge for food scientists. In this context, research on fibril formation, especially amyloid holds much promise. We here first provide concise overview of conditions, which affect formation in proteins. Particular attention directed towards core regions because these sequences promote ordered aggregation. Better understanding process will be key to tailor the process. Especially seeding , that is, adding preformed fibrils...
A TWIN-SHIME system was used to compare the metabolism of pomegranate polyphenols by gut microbiota from two individuals with different urolithin metabotypes. Gut microbiota, ellagitannin metabolism, short-chain fatty acids (SCFA), transport metabolites, and phase II using Caco-2 cells were explored. The simulation reproduced in vivo metabolic profiles for each metabotype. study shows first time that microbial composition, ellagitannins, SCFA differ between metabotypes along large intestine....
Microplastics (MPs) contaminate the global marine and terrestrial ecosystems. This environmental contamination can enter food chain, with MPs found in drinking water, fishery products other categories. Consequently, ingestion is considered main route of human exposure to MPs. Concerns exist on potential act as vectors for pathogenic bacteria, possibly threatening microbial safety. Starting from current evidence foodborne pathogens associated MPs, we review state knowledge putative role...
Plant-processing byproducts of black carrot represent an important disposal problem for the industry; however, they are also promising sources polyphenols, especially anthocyanins. The present study focused on changes in polyphenols from carrot, peel, and pomace during vitro gastrointestinal digestion. Total phenolic content (TPC), total monomeric anthocyanin (TMAC), antioxidant capacity (TAC) were determined using spectrophotometric methods, whereas identification quantification carried out...
The cell nucleus is structurally and functionally organized by lamins, intermediate filament proteins that form the nuclear lamina. Point mutations in genes encode a specific subset of A-type cause spectrum diseases termed laminopathies. Recent evidence points to role for lamins intracellular redox homeostasis. To determine whether lamin A/C depletion prelamin A accumulation differentially induce oxidative stress, we have performed quantitative microscopy-based analysis reactive oxygen...
The present study was developed to determine the ability of polyphenol-rich black carrot and its by-products, i.e., peel pomace, modulate inflammatory response in tumor necrosis factor α (TNF-α) treated endothelial cells after gastrointestinal digestion a co-culture intestinal Caco-2 EA.hy926 cell model.The results indicated that 4 h treatment, transport anthocyanins phenolic acids higher for digested samples (1.3-7%) compared undigested (0-3.3%). transported polyphenols were able...