Svetlana Turcan
A5101644042- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Liver Disease Diagnosis and Treatment
- Pregnancy and Medication Impact
- Cardiac, Anesthesia and Surgical Outcomes
- Diagnosis and treatment of tuberculosis
- Health Systems, Economic Evaluations, Quality of Life
- Diet, Metabolism, and Disease
- Helicobacter pylori-related gastroenterology studies
- Whipple's Disease and Interleukins
- Gastrointestinal disorders and treatments
- Mycobacterium research and diagnosis
- Colorectal Cancer Screening and Detection
- Liver Disease and Transplantation
- Gastroesophageal reflux and treatments
- Tuberculosis Research and Epidemiology
- Celiac Disease Research and Management
- Autoimmune and Inflammatory Disorders
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Surgical Treatments
- Clostridium difficile and Clostridium perfringens research
- Colorectal and Anal Carcinomas
- Lipid metabolism and disorders
- Diverticular Disease and Complications
Moldova State University
2013-2025
Nicolae Testemițanu State University of Medicine and Pharmacy
2020-2025
Objective The incidence of inflammatory bowel disease (IBD) is increasing in Eastern Europe. reasons for these changes remain unknown. aim this study was to investigate whether an East–West gradient the IBD Europe exists. Design A prospective, uniformly diagnosed, population based inception cohort patients 31 centres from 14 Western and eight European countries covering a total background approximately 10.1 million people created. One-third had previous experience with cohorts. Patients were...
The Epi-IBD cohort is a prospective population-based inception of unselected patients with inflammatory bowel disease from 29 European centres covering background population almost 10 million people. aim this study was to assess the 5-year outcome and course Crohn's (CD).Patients were followed up prospectively time diagnosis, including collection their clinical data, demographics, activity, medical therapy, surgery, cancers deaths. Associations between outcomes multiple covariates analysed...
Few population-based cohort studies have assessed the disease course of ulcerative colitis [UC] in era biological therapy and widespread use immunomodulators. The aim this study was to assess 5-year outcome patients with UC Epi-IBD cohort.In a prospective, inception unselected UC, were followed up from time their diagnosis, which included collection clinical data, demographics, activity, medical therapy, rates surgery, cancers, deaths. Associations between outcomes multiple covariates...
The incidence of inflammatory bowel disease (IBD) is increasing in Eastern Europe possibly due to changes environmental factors towards a more "westernised" standard living. aim this study was investigate differences exposure prior diagnosis and Western European IBD patients. EpiCom cohort population-based, prospective inception 1560 unselected patients from 31 countries covering background population 10.1 million. At the time were asked complete an 87-item questionnaire concerning factors....
The aim of the present study was to validate IBD (inflammatory bowel diseases) incidence reported in 2010 ECCO-EpiCom (European Crohn's and Colitis Organization-Epidemiological Committee) inception cohort by including a second independent from participating centers 2011 an Australian center investigate whether there is difference between Eastern Western European countries Australia.Fourteen 5 9 one Australia participated cohort. Patients' data regarding disease type, socio-demographic...
BackgroundThe EpiCom cohort is a prospective, population-based, inception of inflammatory bowel disease (IBD) patients from 31 European centers covering background population 10.1 million. The aim this study was to assess the 1-year outcome in cohort.
Health-related quality of life (HRQoL) is impaired in patients with Inflammatory Bowel Disease (IBD). The aim was prospectively to assess and validate the pattern HRQoL an unselected, population-based inception cohort IBD from Eastern Western Europe. EpiCom consists 1560 31 European centres covering a background population approximately 10.1 million. Patients answered disease specific Short Questionnaire (SIBDQ) generic Form 12 (SF-12) questionnaire at diagnosis after one year follow-up. In...
No direct comparison of health care cost in patients with inflammatory bowel disease across the European continent exists. The aim this study was to assess costs investigations and treatment for diagnostics during first year after diagnosis Europe.The EpiCom cohort is a prospective population-based inception unselected from 31 Western Eastern centers. Patients were followed every third month diagnosis, clinical data regarding collected. Costs calculated euros (€) using Danish Health...
Abstract Background The Epi-IBD cohort is a prospective European population-based of 1,508 patients diagnosed in 2010 and 2011 with inflammatory bowel disease (IBD) according to Copenhagen criteria centres across 17 countries. study aims describe treatment strategies, course prognosis IBD unclassified (IBDU) Europe. Methods Patients IBDU were defined as not fulfilling the diagnostic Crohn’s (CD) or ulcerative colitis (UC), but still required related monitoring. They followed prospectively...
Abstract Background The best maintenance therapy after a steroid-responsive acute severe ulcerative colitis (ASUC) episode remains poorly studied and is not addressed in current guidelines. We aimed to compare the impact of different treatment strategies following hospitalization for ASUC. Methods Multicentric, multinational, retrospective cohort study including patients hospitalized with ASUC, between 2010-2021, who responded intravenous steroids (Oxford Criteria). Patients were categorized...
While there are many etiologies of acute respiratory distress syndrome (ARDS), Lyme disease is not a known cause this disorder, and paucity Lyme-associated ARDS cases reported in the medical literature. In report, we present case 70-year-old woman with requiring mechanical ventilation, who initially had recurrent negative infectious workups but was ultimately diagnosed positive serology western blot. The patient, from New York City metropolitan area, no outdoor exposure, recent travel...
The ECCO-EpiCom study investigates the differences in incidence and therapeutic management of inflammatory bowel diseases [IBD] between Eastern Western Europe. aim this was to analyse disease phenotype, medical therapy, surgery, hospitalization rates 2011 inception cohort during first year after diagnosis. Nine Western, five European centres one Australian centre with 258 Crohn's [CD], 380 ulcerative colitis [UC] 71 IBD unclassified [IBDU] patients [female/male: 326/383; mean age at...
Anaemia is an important complication of inflammatory bowel disease [IBD]. The aim this study was to determine the prevalence anaemia and practice screening during first year following diagnosis, in a European prospective population-based inception cohort.Newly diagnosed IBD patients were included followed prospectively for 1 29 one Australian centre. Clinical data including demographics, medical therapy, surgery blood samples collected. defined according World Health Organization criteria.A...
A definitive diagnosis of Crohn's disease (CD) or ulcerative colitis (UC) is not always possible, and a proportion patients will be diagnosed as inflammatory bowel unclassified (IBDU). The aim the study was to investigate prognosis initially with IBDU course during following 5 years.The Epi-IBD prospective population-based cohort 1289 IBD in centers across Europe. Clinical data were captured prospectively throughout follow-up period.Overall, 476 (37%) CD, 701 (54%) UC, 112 (9%) IBDU. During...
Glutathione S-transferases (GSTM1, GSTT1, and GSTP1) methylenetetrahydrofolate reductase (MTHFR) are important enzymes for protection against oxidative stress. In addition, MTHFR has an essential role in DNA synthesis, repair, methylation. Their polymorphisms have been implicated the pathogenesis of ulcerative colitis (UC). The aim present study was to investigate selected these genes development UC Moldavian population.In a case-control including 128 patients 136 healthy individuals, GSTM1...
The lack of scientific evidence regarding the effectiveness 5-aminosalicylate in patients with Crohn's disease is sharp contrast to its widespread use clinical practice.The aim study was investigate as well course a subgroup who were treated maintenance monotherapy during first year disease.In European community-based inception cohort, 488 followed from time their diagnosis. Information on data, demographics, activity, medical therapy and rates surgery, cancers deaths collected...
The EpiCom study and inception cohort was initiated in 2010 31 centers from 14 Western 8 Eastern European countries, covering a 10.1 million person background population. Our aim to investigate whether there is difference between Europe health care education of patients with inflammatory bowel disease (IBD). A quality (QoC) questionnaire developed the group consisting 16 questions 5 items: time interval onset symptoms diagnosis, information, education, empathy access providers. Of 1,515...
Acid suppressing drugs (ASD) are generally used in acute pancreatitis (AP); however, large cohorts not available to understand their efficiency and safety. Therefore, our aims were evaluate the association between administration of ASDs, outcome AP, frequency gastrointestinal (GI) bleeding GI infection patients with AP. We initiated an international survey performed retrospective data analysis on AP hospitalized January 2013 December 2018. Data 17,422 adult collected from 59 centers 23...
This article presents a synthesis of publications from the relevant scientific literature, addressed to importance nutritional treatment in patients with inflammatory bowel diseases (IBD). Various restrictive and elimination diets are critically reviewed perspective evidence-based medicine, including: exclusive enteral nutrition, low-FODMAP, specific carbohydrate, paleolithic, anti-inflammatory, CD-TREAT, other diets. Although there countless books websites on „medical nutrition” IBD, is no...
Whipple's disease (WD) is a rare chronic systemic caused by the Gram-positive bacillus Tropheryma whipplei. Despite over 100 years of observation and study history this disease, it still remains difficult diagnostic therapeutic challenge.Authors report case 38-year-old man with long-time PPIs treatment because GERD no other clinical paraclinical symptoms. Endoscopic slightly enlarged villi, accumulation whitish matter at tip villi distal duodenal mucosa periodic acid-Schiff staining positive...
Background: The EpiCom-cohort is a European prospective population-based cohort of unselected, uniformly diagnosed patients with inflammatory bowel disease (IBD) in 2010 centres from Western and Eastern countries. aims at describing differences occurrence, treatment strategies, course prognosis within Europe. Methods: Patients were followed each 3rd month for the first year after diagnosis then according to treating physician 2–5th follow-up. Clinical data on surgery, hospitalizations...