A5079160619- Inflammatory Bowel Disease
- Microscopic Colitis
- Advanced Glycation End Products research
- Systemic Lupus Erythematosus Research
- Eosinophilic Esophagitis
- Atherosclerosis and Cardiovascular Diseases
- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Gut microbiota and health
- Chronic Lymphocytic Leukemia Research
- Alcohol Consumption and Health Effects
- Lymphoma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Drug Transport and Resistance Mechanisms
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Analytical Chemistry and Chromatography
- Vitamin D Research Studies
- Biomarkers in Disease Mechanisms
- Liver Diseases and Immunity
- Pregnancy and Medication Impact
- Diagnosis and treatment of tuberculosis
- Connexins and lens biology
- Natural Antidiabetic Agents Studies
- Gastrointestinal motility and disorders
- Clostridium difficile and Clostridium perfringens research
University Hospital Centre Zagreb
2016-2025
University of Zagreb
1997-2022
Klinički Bolnički Centar Rijeka
2018
NHS Lothian
2014
University Gastroenterology
2009
Klinička bolnica Merkur
2003-2004
The incidence of inflammatory bowel disease (IBD) is increasing in Eastern Europe possibly due to changes environmental factors towards a more "westernised" standard living. aim this study was investigate differences exposure prior diagnosis and Western European IBD patients. EpiCom cohort population-based, prospective inception 1560 unselected patients from 31 countries covering background population 10.1 million. At the time were asked complete an 87-item questionnaire concerning factors....
The knowledge on how gut microbes contribute to the inflammatory bowel disease (IBD) at onset of is still scarce. We compared microbiota in newly diagnosed, treatment-naïve adult IBD (Crohn's (CD) and ulcerative colitis (UC)) irritable syndrome (IBS) patients healthy group. Mucosal fecal 49 (13 UC, 10 CD, 26 IBS) before treatment initiation, 12 subjects was characterized by 16S rRNA gene sequencing. Mucosa sampled six positions, from terminal ileum rectum. demonstrate that mucosal spatially...
BackgroundThe EpiCom cohort is a prospective, population-based, inception of inflammatory bowel disease (IBD) patients from 31 European centers covering background population 10.1 million. The aim this study was to assess the 1-year outcome in cohort.
Janus kinase inhibitors open new horizons for small-molecule drugs in treating inflammatory bowel disease, with ritlecitinib demonstrating significant efficacy clinical trials ulcerative colitis and Crohn's disease. Ritlecitinib, a second-generation JAK3 inhibitor, is novel therapeutic agent alopecia areata other autoimmune conditions. A stability-indicating UHPLC-DAD-MS/MS method was developed, validated, applied forced degradation study of under ICH guidelines. The demonstrated high...
Abstract Background Infliximab remains a cornerstone in managing inflammatory bowel disease (IBD) patients. The recent introduction of subcutaneous (SC) infliximab offers potential alternative to intravenous (IV) administration. However, the optimal timing switch is still unclear. We aimed investigate difference mucosal healing rates and therapy persistence patients switched SC at week 6 as opposed those maintained on IV therapy. Methods All starting treatment from January 2023 April 2024...
Abstract Background Despite being in clinical remission, patients with inflammatory bowel disease (IBD) on biologic therapy may experience faecal incontinence (FI) and urgency, significantly impacting their quality of life. This study aimed to determine the prevalence FI urgency this population identify associated risk factors. Methods A cross-sectional was conducted a tertiary referral centre, including IBD remission (evaluated by partial Mayo score or Harvey-Bradshaw Index). Data...
The high incidence of bone disease and the increasing evidence Crohn's (CD) decline in corticosteroid users nonusers suggest that metabolism is affected by inflammatory process. aim study was to compare serum levels proinflammatory cytokines, markers turnover regulatory molecules osteoclast biogenesis, receptor activator nuclear factor kappaB-ligand (RANKL) osteoprotegerin (OPG), between naïve long-standing CD patients.The included 95 patients, 15 them with newly diagnosed previously...
Anaemia is an important complication of inflammatory bowel disease [IBD]. The aim this study was to determine the prevalence anaemia and practice screening during first year following diagnosis, in a European prospective population-based inception cohort.Newly diagnosed IBD patients were included followed prospectively for 1 29 one Australian centre. Clinical data including demographics, medical therapy, surgery blood samples collected. defined according World Health Organization criteria.A...
Abstract Collagenous proteins are especially prone to nonenzymatic glycation, because they contain several dibasic amino acid residues with free groups, have a very slow turnover rate, and exposed ambient levels of glucose. The aim this study was determine the time-dependent course advanced glycation process in diabetic rats relation glycemic control duration diabetes, compared age-matched controls. Immunochemical assay antibodies end products (AGE) first developed qualitatively detect...
The EpiCom study and inception cohort was initiated in 2010 31 centers from 14 Western 8 Eastern European countries, covering a 10.1 million person background population. Our aim to investigate whether there is difference between Europe health care education of patients with inflammatory bowel disease (IBD). A quality (QoC) questionnaire developed the group consisting 16 questions 5 items: time interval onset symptoms diagnosis, information, education, empathy access providers. Of 1,515...
ABSTRACT Adrenocortical carcinoma (ACC) is a rare malignancy with an incompletely understood pathogenesis and poor prognosis. The adrenalytic activity of mitotane has made it the most important single drug in treatment ACC. Unfortunately, exact mechanism action still unknown. It believed that belongs to class drugs require metabolic transformation by cytochrome P450 for therapeutic action; therefore determination plasma levels not only but also its metabolites would help carrying out...
Abstract Medication adherence is an important factor in inflammatory bowel disease therapy, which includes regular supplementation of malabsorbed vitamins. Absorption folic acid limited due to the damaging gastrointestinal tract, can increase chances develop megaloblastic anaemia and colorectal cancer. In this work, 5-aminosalicylates (mesalazine, balsalazide, sulfasalazine olsalazine) were characterized regarding their pharmacokinetic related properties (hydrophobicity, phospholipid plasma...
The impact of sexuality and quality life (QOL) is one the main concerns IBD. Despite obvious relevance this problem, knowledge extent sexual dysfunction (SD) in IBD limited. Aim study was to assess prevalence SD erectile (ED), QOL their predictors, age-related dynamic patients.In cross-sectional study, 202 patients [122 male, 80 female, 133 Crohn's disease (CD), 69 ulcerative colitis (UC)] fulfilled International Index Erectile Function (IIEF) or Female Sexual Functioning (FSFI). assessed...
Etrasimod, a novel selective sphingosine-1-phosphate receptor modulator, was recently approved by the U.S. Food and Drug Administration European Medicinal Agency for treatment of moderately to severely active ulcerative colitis in adults. In this research, forced degradation study as an integral part drug product packaging development, which generates data on mechanisms, is published. The development validation stability-indicating method using superior high-performance liquid chromatography...
With the increase in number of medicines patients have to take, there has been a rapid rise fixed-dose combinations (FDCs) last two decades. Prior FDC development, pharmacokinetic properties active pharmaceutical ingredients (APIs) be evaluated, as well methods for their determination developed. So patient compliance inflammatory bowel disease, three novel FDCs thiopurine immunosuppressants and folic acid are proposed; physico-chemical such hydrophobicity, lipophilicity plasma protein...
Non-enzymatic glycation leading to advanced endproduct (AGE) formation is thought contribute vascular pathology. In the present study, AGEs and anti-AGE antibodies in free immune complex-bound form were assayed serum of diabetic (DMCAD) (n = 69) nondiabetic 78) patients with coronary artery disease (CAD) control subjects 47) from disease.A blocking enzyme-linked immunosorbent assay (ELISA) was used test immunoreactivity against AGE epitope(s) a competitive ELISA measure total...
Abstract Size exclusion chromatography (SEC) has become a powerful tool for analysing size variants of biologic drugs in their native form. Modern SEC can be defined by the use chromatographic columns packed with sub-3 µm particles, allowing an increase method throughput compared to that conventional SEC. We performed forced degradation study adalimumab, first genetically engineered fully humanised immunoglobulin G1 monoclonal antibody, and evaluated tha possibilities advanced column...