A5023799916- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Organ Transplantation Techniques and Outcomes
- Hepatitis Viruses Studies and Epidemiology
- Monoclonal and Polyclonal Antibodies Research
- Telomeres, Telomerase, and Senescence
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Viral gastroenteritis research and epidemiology
- Pediatric Hepatobiliary Diseases and Treatments
- Animal Virus Infections Studies
- Cytomegalovirus and herpesvirus research
- HIV/AIDS drug development and treatment
- Systemic Lupus Erythematosus Research
- Alcohol Consumption and Health Effects
- Renal Transplantation Outcomes and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Bacteriophages and microbial interactions
- Cystic Fibrosis Research Advances
- T-cell and B-cell Immunology
University College London
1991-2023
Institute for Liver Health
2023
The Royal Free Hospital
1991-2022
Roland Hill (United Kingdom)
2020-2022
Royal Free London NHS Foundation Trust
2018-2019
National Health Service
1995-2018
Cambridge University Hospitals NHS Foundation Trust
2004-2018
Addenbrooke's Hospital
2008-2017
Imperial College London
1992-2017
University of Oxford
2017
Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for major histocompatibility complex class I molecules as means of controlling their activity. We show that genes encoding the NK cell receptor KIR2DL3 its human leukocyte antigen C group 1 (HLA-C1) ligand directly influence resolution hepatitis virus (HCV) infection. This effect was observed in Caucasians African Americans with expected low infectious doses HCV but not...
The role of liver transplantation in patients positive for the hepatitis B surface antigen (HBsAg) is controversial because high rate recurrent virus (HBV) infection. It has not been determined whether this risk greater certain and administration anti-hepatitis (anti-HBs) immune globulin beneficial.
Abstract Non-alcoholic fatty liver disease (NAFLD) is an increasingly common condition, strongly associated with the metabolic syndrome, that can lead to progressive hepatic fibrosis, cirrhosis and failure. Subtle inter-patient genetic variation environmental factors combine determine in progression. A non-synonymous polymorphism TM6SF2 (rs58542926 c.449 C>T, p.Glu167Lys) was recently increased triglyceride content, but whether this variant promotes clinically relevant fibrosis unknown....
OBJECTIVE--To see whether intravenous acetylcysteine would improve outcome in patients with fulminant hepatic failure after paracetamol overdose. DESIGN--A prospective randomised controlled study. SETTING--The Institute of Liver Studies, King's College Hospital, London. PATIENTS--50 consecutive (21 male) aged 16-60 overdose who had not previously received acetylcysteine. INTERVENTIONS--Conventional intensive liver care plus either (25 patients) the same dose regimen as used early a overdose,...
Long-term follow-up of 27 patients with hepatitis B virus-related chronic liver disease treated by transplantation showed that 23 had virus recurrence. In 13 late changes in the grafts were similar to those described other series: minor abnormalities five cases, active cases and non-hepatitis graft dysfunction three cases. Three incomplete histological follow-up. Analysis viral antigen expression six revealed a distinct novel pattern termed fibrosing cholestatic hepatitis. Development was...
Non-insulin-dependent diabetes mellitus (NIDDM) may be associated with chronic hepatitis C virus (HCV) infection. This was studied further in two parts. First, 1,151 patients HCV-related cirrhosis and 181 B (HBV)-related cirrhosis, well matched for age, sex, severity of were reviewed retrospectively. The prevalence higher (23.6%) than HBV-related (9.4%; odds ratio [OR], 2.78; 95% confidence interval [CI], 1.6-4.79; P =.0002). closely the Child-Pugh score (OR, 3.83; CI, 2. 38-6.17; <.0001)...
<h3>Background</h3> Clinicians use fibrosis in a liver biopsy to predict clinical outcomes of chronic disease. The performance non-invasive tests has been evaluated against histological assessment but as the reference standard would be ideal. enhanced (ELF) test was derived and validated large cohort patients shown have high diagnostic accuracy (area under curve (AUC)=0.80 95% CI 0.76 0.85) identification significant on biopsy. <h3>Objective</h3> To evaluate ELF predicting by following up...
Primary biliary cholangitis (formerly known as primary cirrhosis, PBC) is an autoimmune liver disease in which a cycle of immune mediated epithelial cell injury, cholestasis and progressive fibrosis can culminate over time end-stage cirrhosis. Both genetic environmental influences are presumed relevant to initiation. PBC most prevalent women those the age 50, but spectrum recognised adult patients globally; male sex, younger at onset (<45) advanced presentation baseline predictors poorer...
These guidelines on the management of primary sclerosing cholangitis (PSC) were commissioned by British Society Gastroenterology liver section. The guideline writing committee included medical representatives from hepatology and gastroenterology groups as well patient PSC Support. aim to support general physicians, gastroenterologists surgeons in managing adults with or those presenting similar cholangiopathies which may mimic PSC, such IgG4 cholangitis. It also acts a reference for patients...
Chinese translation Background: Hepatitis C virus (HCV) infections occur worldwide and either spontaneously resolve or persist markedly increase the person's lifetime risk for cirrhosis hepatocellular carcinoma. Although HCV persistence occurs more often in persons of African ancestry with genetic variants near interleukin-28B (IL-28B), basis is not well-understood. Objective: To evaluate host spontaneous resolution infection. Design: 2-stage, genome-wide association study. Setting: 13...
Hepatocellular carcinoma (HCC) has a poor prognosis with limited therapeutic options. We propose that local immune responses in patients HCC are held check by tumor-infiltrating CD4(+)CD25(+) T-regulatory lymphocytes (T(reg) cells), which suppress the activity and proliferation of effector CD4(+) CD8(+) T cells. The phenotype cell cycle status (TILs) were analyzed via immunohistochemistry sections from undergoing surgery for flow cytometry peripheral blood mononuclear cells TILs isolated...
Diclofenac is a nonsteroidal anti-inflammatory drug that causes rare but serious hepatotoxicity, the mechanism of which unclear. The purpose present study was to explore potential role played by immune processes. Antibodies diclofenac metabolite-modified liver protein adducts were detected in sera seven out patients with diclofenac-induced 12 20 subjects on without and none four healthy controls. antibodies recognized expressed livers from rats treated multiple doses diclofenac, not those...
The hypoxaemia of hepatopulmonary syndrome, seen in severe chronic liver dysfunction, occurs as a result precapillary pulmonary arterial dilatation and arteriovenous communications. These abnormalities contribute to the mismatch between ventilation perfusion, right left blood flow shunting. Nitric oxide (NO) is powerful vasodilator concerned with regulation vascular tone man. Using chemiluminescence analyser, we have measured endogenously produced NO exhaled air three patients six...
The incidence of primary liver cancer (PLC) is increasing in Western Europe. To understand trends over time and the current burden UK, a detailed analysis epidemiology PLC its subtypes was conducted.Data on PLCs diagnosed during 1997-2017 were obtained from population-based, nationwide registries UK. European age-standardised (ASR) incidence-based mortality rates (ASMR) per 100,000 person-years calculated overall by sex UK-nation. Annual percentage change estimated using Joinpoint...
Previous studies demonstrated that peripheral blood lymphocytes are cytotoxic to autologous hepatocytes in patients with chronic hepatitis B virus infection. We examined whether cytotoxicity is specifically directed against expressing HBsAg or HBcAg. Viral antigens were detected by immunofluorescence isolated before and after exposure T non-T from 28 HBV infection an assay. There was significant reduction the percentage of HBcAg-positive and, a lesser extent, cells; not affected. Other...