A5085300497- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease and Transplantation
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Drug Transport and Resistance Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Systemic Lupus Erythematosus Research
- Phagocytosis and Immune Regulation
- HIV/AIDS drug development and treatment
- Pharmacogenetics and Drug Metabolism
- Hepatitis Viruses Studies and Epidemiology
- Liver physiology and pathology
- Inflammatory Bowel Disease
- Pharmacological Effects and Toxicity Studies
- Alcohol Consumption and Health Effects
- Microscopic Colitis
- Pharmacological Effects of Natural Compounds
- Organ Transplantation Techniques and Outcomes
- Glycosylation and Glycoproteins Research
- Metabolism and Genetic Disorders
- Chronic Lymphocytic Leukemia Research
Icahn School of Medicine at Mount Sinai
2015-2024
Mount Sinai Medical Center
1991-2019
Catalina Research Institute
2018
Novo Nordisk (Switzerland)
2018
Second Genome (United States)
2018
Glympse Bio
2018
Institut thématique Génétique, génomique et bioinformatique
2017
Janssen Scientific Affairs (United States)
2017
Janssen (United States)
2017
Janssen (Belgium)
2016
Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are uncommon liver diseases of unknown etiology. Reported clustering PBC cases may be due to environmental factors. Individuals with have a high prevalence thyroid disease is reportedly more prevalent near Superfund toxic waste sites (SFS). The objective this study was examine the potential individuals PSC SFS. De-identified clinical demographic data were used determine observed for each New York City zip code (n = 174)...
Summary Background Little is known about the role of microbiome in primary sclerosing cholangitis. Aim To explore mucosa‐associated microbiota cholangitis (PSC) patients across different locations gut, and to compare it with inflammatory bowel disease (IBD)‐only healthy controls. Methods Biopsies from terminal ileum, right colon, left colon were collected controls undergoing colonoscopy. Microbiota profiling using bacterial 16S rRNA sequencing was performed on all biopsies. Results...
Bile duct loss during the course of drug-induced liver injury is uncommon, but can be an indication vanishing bile syndrome (VBDS). In this work, we assess frequency, causes, clinical features, and outcomes cases with histologically proven loss. All enrolled into a prospective database over 10-year period that had undergone biopsies (n = 363) were scored for presence assessed laboratory outcomes. Twenty-six 363 patients (7%) drug-, herbal-, or dietary-supplement-associated on biopsy, which...
The close association between autoantibodies against pyruvate dehydrogenase-E2 (PDC-E2), a ubiquitous mitochondrial protein, and primary biliary cirrhosis (PBC) is unexplained. Many autoantigens are selectively modified during apoptosis, which has focused attention on apoptotic cells as potential source of "neo-antigens" responsible for activating autoreactive lymphocytes. Since increased apoptosis bile duct epithelial (cholangiocytes) evident in patients with PBC, we evaluated the effect...
The close association between autoantibodies against pyruvate dehydrogenase-E2 (PDC-E2), a ubiquitous mitochondrial protein, and primary biliary cirrhosis (PBC) is unexplained. Many autoantigens are selectively modified during apoptosis, which has focused attention on apoptotic cells as potential source of "neo-antigens" responsible for activating autoreactive lymphocytes. Since increased apoptosis bile duct epithelial (cholangiocytes) evident in patients with PBC, we evaluated the effect...
Abstract Kruppel-like factor 6 (KLF6) is a tumor suppressor gene inactivated in prostate and colon cancers, as well astrocytic gliomas. Here, we establish that KLF6 mediates growth inhibition through an interaction with cyclin D1, leading to reduced phosphorylation of the retinoblastoma protein (Rb) at Ser795. Furthermore, introduction disrupts D1-cyclin-dependent kinase (cdk) 4 complexes forces redistribution p21Cip/Kip onto cdk2, which promotes G1 cell cycle arrest. Our data suggest...
The binding of multivalent immunoglobulin G complexes to Fc receptors (Fc γ Rs) on macrophages activates multiple immune functions. A murine macrophage cell line, but not a fibroblast that was transfected with human RIIA mediated phagocytosis and an intracellular Ca 2+ concentration ([Ca ] i ) flux upon cross-linking RIIA. Transfected expressed truncated receptor lacking 17 carboxy-terminal amino acids phagocytosed small antibody complexes. However, only wild-type transfectants labeled...
Owing to increased obesity, non-alcoholic fatty liver disease (NAFLD) is now the most prevalent in United States. NAFLD considered a component of metabolic syndrome, cluster disorders that also includes diabetes mellitus, dyslipidemia, arteriosclerosis, and hypertension. Exposure ambient air particulate matter with aerodynamic diameters < 2.5 μm (PM2.5) risk factor for arteriosclerosis lung disease, but its effect on unknown. PM2.5 induces pulmonary dysfunction via Toll-like receptor (TLR)...
Owing to increased obesity, non-alcoholic fatty liver disease (NAFLD) is now the most prevalent in United States. NAFLD considered a component of metabolic syndrome, cluster disorders that also includes diabetes mellitus, dyslipidemia, arteriosclerosis, and hypertension. Exposure ambient air particulate matter with aerodynamic diameters < 2.5 microm (PM(2.5)) risk factor for arteriosclerosis lung disease, but its effect on unknown. PM(2.5) induces pulmonary dysfunction via Toll-like receptor...
Azithromycin (AZ) is a widely used antibiotic. The aim of this study was to characterise the clinical features, outcomes, and HLA association in patients with drug-induced liver injury (DILI) due AZ.
Anti-mitochondrial antibodies (AMAs) have long been recognized as a serological hallmark of primary biliary cirrhosis (PBC). Although high titers immunoglobulin (Ig)A AMAs are found in bile, saliva, and urine patients, pathogenic role for this antibody has remained elusive. Functional studies IgA general impeded by low quantities the inability to recover antigen-specific dimeric form. Using newly defined synthetic group A. Streptococcus derived peptide, we purified large monomeric from...
Summary Background The relationships between primary sclerosing cholangitis ( PSC ) and the environment are largely unknown. Aim To validate associations reported in previous studies to identify novel environmental exposures among patients. Methods We performed a multicenter, case–control analysis utilising self‐administered questionnaires. Responses cases n = 1000) controls 663) were compared using multivariable logistic regression adjusted for age gender. model was further stratified based...