A5051030528- Atrial Fibrillation Management and Outcomes
- Blood Pressure and Hypertension Studies
- Hormonal and reproductive studies
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Heart Rate Variability and Autonomic Control
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Promotion and Cardiovascular Prevention
- Lipoproteins and Cardiovascular Health
- Cardiovascular Health and Disease Prevention
- Acute Ischemic Stroke Management
- Health Systems, Economic Evaluations, Quality of Life
- Obesity and Health Practices
- Pharmacological Effects and Assays
- Diabetes Treatment and Management
- Health, Environment, Cognitive Aging
- Global Public Health Policies and Epidemiology
- Hypothalamic control of reproductive hormones
- Primary Care and Health Outcomes
- Birth, Development, and Health
- Cardiac Arrhythmias and Treatments
- GDF15 and Related Biomarkers
- Health and Medical Research Impacts
- Social and Behavioral Studies
Finnish Institute for Health and Welfare
2016-2024
Turku University Hospital
2020
University of Turku
2020
Framingham Heart Study
2017
National Heart Lung and Blood Institute
2017
Universität Hamburg
2017
University Medical Center Hamburg-Eppendorf
2017
Joint Research Centre
2011-2016
National Institutes of Health
2015
NILU
2009
Atrial fibrillation (AF) is a common cardiac disease in aging populations with high comorbidity and mortality. Sex differences AF epidemiology are insufficiently understood.In N=79 793 individuals without diagnosis at baseline (median age, 49.6 years; age range, 24.1-97.6 51.7% women) from 4 community-based European studies (FINRISK, DanMONICA, Moli-sani Northern Sweden) of the BiomarCaRE consortium (Biomarker for Cardiovascular Risk Assessment Europe), we examined incidence, its association...
Neuronal assemblies within the nervous system produce electrical activity that can be recorded in terms of action potential patterns. Such patterns provide a sensitive endpoint to detect effects variety chemical and physical perturbations. They are function synaptic changes do not necessarily involve structural alterations. In vitro neuronal networks (NNs) grown on micro-electrode arrays (MEAs) respond neuroactive substances as well vivo brain. As such, they constitute valuable tool for...
Accurate blood pressure measurements are needed in clinical practice, intervention studies and health examination surveys. Blood sensitive: their accuracy can be affected by measurement environment, behaviour of the subject, procedures, devices used for observer. To minimize errors measurement, a standardized protocol is needed.The European Health Examination Survey (EHES) Pilot project was conducted 2009-2012. A pilot survey 12 countries using protocol. The protocols each survey, training...
The Reference Values for Arterial Stiffness Collaboration has derived an equation using age and mean blood pressure to estimated pulse wave velocity (ePWV), which predicted cardiovascular events independently of Systematic COoronary Risk Evaluation (SCORE) Framingham Score. study aim was investigate the independent association between ePWV clinical outcomes in 107 599 apparently healthy subjects (53% men) aged 19 97 years from MORGAM Project who were included 1982 2002 38 cohorts 11...
Abstract Background Chronic kidney disease has emerged as a strong cardiovascular risk factor, and in many current guidelines, it is already considered coronary heart (CHD) equivalent. Routinely, creatinine been used the main marker of renal function, but recently, cystatin C more promising marker. The aim this study was to assess comparative mortality chronic (CKD) using C-based creatinine-based equations estimated glomerular filtration rate (eGFR) participants population-based cohorts....
Abstract Background Biomarkers may contribute to improved cardiovascular risk estimation. Glycated hemoglobin A 1c (HbA ) is used monitor the quality of diabetes treatment. Its strength association with outcomes in general population remains uncertain. This study aims assess HbA population. Methods Data from six prospective population-based cohort studies across Europe comprising 36,180 participants were analyzed. was evaluated conjunction classical factors (CVRFs) for mortality, disease...
Background Atrial fibrillation is the most common serious abnormal heart rhythm, and a frequent cause of ischaemic stroke. Recent experimental studies, mainly in orchiectomised rats, report relationship between sex hormones atrial electrophysiology electroanatomy. We aimed to evaluate whether low testosterone levels are predictive for and/or stroke men women. Design methods The serum total were measured at baseline population cohort 7892 subjects (3876 male, 4016 female), aged 25-74 years,...
Abstract Aims Although absolute (AID) and functional iron deficiency (FID) are known risk factors for patients with cardiovascular (CV) disease, their relevance the general population is unknown. The aim was to assess association between AID/FID incident CV disease mortality in population. Methods results In 12 164 individuals from three European population‐based cohorts, AID defined as ferritin < 100 μg/L or 30 (severe AID), FID 100–299 transferrin saturation 20%. coronary heart (CHD),...
High-sensitivity troponin I (hs-cTnI) concentrations reflect myocardial stress. The role of hs-cTnI in predicting long-term changes the risk cardiovascular disease (CVD) general populations is not clearly defined.We investigated whether change 3 repeated measures collected 5 years apart a prospective Danish study (3875 participants, initially aged 30-60 years, 51% female, free at baseline) improves 10-year prediction incident CVD compared to using single most recent measurement. process was...
Most studies reporting on the association of circulating testosterone levels with type 2 diabetes in men are cross-sectional design. Reports relevance altered women scarce. Here, we evaluate role low serum for incident and a population setting 7706 subjects (3896 females). During mean follow up time 13.8 years, 7.8% developed diabetes. Significant correlations high density lipoprotein (HDL)-cholesterol (R = 0.21, p < 0.001), body-mass-index −0.23, waist-to-hip-ratio −0.21, 0.001) were...
Background Waist circumference and hip are both strongly associated with risk of death; however, their joint association has rarely been investigated. Methods Results The MONICA Risk, Genetics, Archiving, Monograph (MORGAM) Project was conducted in 30 cohorts from 11 countries; 90 487 men women, aged to 74 years, predominantly white, no history cardiovascular disease, were recruited 1986 2010 followed up for 24 years. Hazard ratios estimated using sex‐specific Cox models, stratified by...
Abstract Aims Classical cardiovascular risk factors (CVRFs), biomarkers, and common genetic variation have been suggested for assessment of atrial fibrillation (AF). To evaluate their clinical potential, we analysed individual combined ability AF prediction. Methods results In N = 6945 individuals the FINRISK 1997 cohort, assessed predictive value CVRF, N-terminal pro B-type natriuretic peptide (NT-proBNP), 145 recently identified single-nucleotide polymorphisms (SNPs) in a developed...
Abstract Aims Limited evidence is available on the temporal relationship between atrial fibrillation (AF) and ischaemic stroke their impact mortality in community. We sought to understand of AF determine sequence disease onset relation mortality. Methods results Across five prospective community cohorts Biomarkers for Cardiovascular Risk Assessment Europe (BiomarCaRE) project we assessed baseline cardiovascular risk factors 100 132 individuals, median age 46.1 (25th–75th percentile...
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Natriuretic peptides are extensively studied biomarkers for atrial fibrillation (AF) and heart failure (HF). Their role in the pathogenesis of both diseases is not entirely understood previous studies several single-nucleotide polymorphisms (SNPs) at NPPA-NPPB locus associated with natriuretic have been identified. We investigated causal relationship between AF as well HF using a Mendelian randomization approach.N-terminal pro B-type peptide (NT-proBNP) (N = 6669), (BNP) 6674), mid-regional...
Chronic kidney disease (CKD) has a complicated relationship with the heart, leading to many adverse outcomes. The aim of this study was evaluate between CKD and incidence atrial fibrillation (AF) heart failure (HF) along mortality as competing risk in general population cohorts. We also included an assessment baseline biomarkers inflammation, myocardial injury, left ventricular dysfunction AF HF, respectively, shed light on potential underlying pathophysiology.
The Virtual Cell Based Assay (VCBA) was applied to simulate the long-term (repeat dose) toxic effects of chemicals, including substances in cosmetics and personal care products. presented model is an extension original VCBA for simulation single exposure implemented a KNIME workflow. This work illustrates steps taken repeated dose two reference compounds, caffeine amiodarone. Using caffeine, vitro experimental viability data from human liver cell lines, HepG2 HepaRG, were measured used...
The relevance of low testosterone concentrations for incident coronary heart disease (CHD) and mortality has been discussed in various studies. Here, we evaluate the predictive value baseline levels a large population-based cohort.We measured serum 7671 subjects (3710 male, 3961 female) FINRISK97 study.The median follow-up (FU) was 13.8 years. During FU, total 779 deaths from any cause, 395 CHD events were recorded. age-adjusted similar suffering during FU those without (men: 15.80 vs. 17.01...
Abstract Aims The increased incidence of heart failure in men suggests that endogenous sex hormones might play a role the development failure, but epidemiological data remain sparse. Here, we evaluated predictive value low testosterone levels on future large population‐based FINRISK97 study. Methods and results Baseline serum concentrations were measured 7855 subjects (3865 3990 women) During median follow‐up (FU) 13.8 years, total 564 events recorded. age‐adjusted baseline did not differ...
Stroke is a common cause of death and leading disability morbidity. risk assessment remains challenge, but circulating biomarkers may improve prediction. Controversial evidence available on the predictive ability troponin concentrations stroke in community. Furthermore, reports value for different subtypes are scarce.High-sensitivity cardiac I (hsTnI) were assessed 82 881 individuals (median age, 50.7 years; 49.7% men) free or myocardial infarction at baseline from 9 prospective European...