A5040666392- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Peripheral Artery Disease Management
- Coronary Interventions and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Gastroesophageal reflux and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Imaging and Diagnostics
- Pregnancy and preeclampsia studies
- Pharmacogenetics and Drug Metabolism
- Pharmacovigilance and Adverse Drug Reactions
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood Pressure and Hypertension Studies
- Cardiac Health and Mental Health
- Congenital Heart Disease Studies
- Frailty in Older Adults
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Disease and Adiposity
- Biomedical Text Mining and Ontologies
- Lipoproteins and Cardiovascular Health
- Helicobacter pylori-related gastroenterology studies
- Eicosanoids and Hypertension Pharmacology
Copenhagen University Hospital
2022-2024
Rigshospitalet
2016-2024
Zealand University Hospital
2021-2023
Bispebjerg Hospital
2020-2023
Frederiksberg Hospital
2019-2022
Roskilde University
2022
Danish National Research Foundation
2016-2022
Gentofte Hospital
2015-2021
University of Copenhagen
2015-2016
Technical University of Denmark
2016
Guidelines differ in their recommendations on therapy to prevent gastrointestinal bleeding for patients treated with dual antiplatelet treatment (DAPT). We sought investigate the effectiveness of proton pump inhibitors (PPIs) upper (UGI) using DAPT following myocardial infarction (MI) relation current European Society Cardiology guidelines recommendations.We linked Danish nationwide registries identify taking 7 days hospital discharge an acute MI, and excluded individuals anticoagulation...
Abstract Background Use of proton pump inhibitors ( PPI s) has been associated with cardiovascular disease amongst patients not on antiplatelet therapy. The associations use, duration and dose, risk first‐time ischemic stroke myocardial infarction MI ) are poorly understood. Methods All Danish individuals no prior history or stroke, who had an elective upper gastrointestinal endoscopy performed between 1997 2012, were identified from nationwide registries. We used multiple Poisson regression...
In the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial, anti-inflammatory monoclonal antibody canakinumab significantly reduced risk of recurrent cardiovascular events in patients with previous myocardial infarction (MI) and high-sensitivity C-reactive protein (hs-CRP) levels 2 mg/L or greater.To estimate cost-effectiveness adding to standard care for secondary prevention major over a range potential prices.A state-transition Markov model was constructed costs outcomes...
The Reference Values for Arterial Stiffness Collaboration has derived an equation using age and mean blood pressure to estimated pulse wave velocity (ePWV), which predicted cardiovascular events independently of Systematic COoronary Risk Evaluation (SCORE) Framingham Score. study aim was investigate the independent association between ePWV clinical outcomes in 107 599 apparently healthy subjects (53% men) aged 19 97 years from MORGAM Project who were included 1982 2002 38 cohorts 11...
Abstract Aims In a continuously ageing population of patients with congenital heart disease (CHD), understanding the long-term risk morbidity is crucial. The aim this study was to compare lifetime risks developing comorbidities in simple CHD and matched controls. Methods results Using Danish nationwide registers spanning from 1977 2018, cases were defined as isolated atrial septal defect (ASD), ventricular (VSD), pulmonary stenosis, or patent ductus arteriosus surviving until at least 5...
Abstract Aims Pre-eclampsia increases women’s lifetime risk of cardiovascular disease (CVD). Little is known about the trajectory CVD after pre-eclampsia, limiting usefulness this knowledge for informing screening, prevention, and interventions. We investigated when pre-eclampsia how changes over time since pregnancy. Methods results This register-based study included 1 157 666 women with >1 pregnancy between 1978 2017. Cumulative incidences acute myocardial infarction (AMI) ischaemic...
Abstract Aims Outcomes after myocardial infarction (MI) improved during recent decades alongside better risk factor management and implementation of guideline-recommended treatments. However, it is unknown whether this applies to stable patients who are event-free 1 year MI. Methods results Using nationwide Danish registries, we included all with first-time MI 2000–17 survived free from bleeding cardiovascular events (n = 82 108, median age 64 years, 68.2% male). Follow-up started continued...
Background and aimsFew studies have determined whether the declining incidence of myocardial infarction carries into current decade, how it is affected by age sex. We aimed to determine age- sex-specific changes in Denmark from 2005 through 2021.MethodsFirst-time admissions adults aged ≥18 years were identified Danish nationwide registries. Incidence rates per 100,000 persons with 95% confidence intervals (CI) calculated across calendar year, sex, groups (≤49, 50–69, 70–84, ≥85 years). also...
Background Being overweight or obese is associated with a greater risk of coronary heart disease and stroke compared normal weight. The role the specific adipose tissue-derived substances, called adipocytokines, in overweight- obesity-related cardiovascular (CVD) still unclear. Objective To investigate associations three substances: adiponectin, leptin, interleukin-6 incident CVD longitudinal population-based study, including extensive adjustments for traditional metabolic factors closely...
Abstract Background Treatment with beta-blockers is currently recommended after myocardial infarction (MI). The evidence relies on trials conducted decades ago before implementation of revascularization and contemporary medical therapy or in enrolling patients heart failure reduced left ventricular ejection fraction (LVEF ≤ 40%). Accordingly, the impact mortality morbidity following acute MI without LVEF unclear. Methods/design Danish trial beta-blocker treatment (DANBLOCK) a prospective,...
Abstract Background The risk of peripheral artery disease (PAD) in patients with diabetes mellitus (DM) and coronary (CAD) is an important inadequately addressed issue. Our aim to examine the impact DM on PAD different degrees CAD characterized by angiography (CAG). Methods Using nationwide registers we identified all aged ≥18 years, undergoing first time CAG between 2000 2012. Patients were categorized into DM/Non-DM group, further classified categories according degree i.e., no-vessel...
Although overweight and obesity are associated with cardiovascular disease (CVD), it is unclear which clinical measure of the strongest predictor CVD, whether various measures indeed independent predictors CVD.This study was a prospective population-based 2493 Danish men women, age 41-72 years, without major CVD at baseline. At baseline, body mass index, waist circumference, hip waist-to-hip ratio (WHR), traditional new risk factors were recorded.Over median follow-up 12.6 incidence combined...
Background Guidelines recommend that patients with myocardial infarction (MI) receive equal care regardless of age. However, withholding treatment may be justified in elderly and frail patients. This study aimed to investigate trends treatments outcomes older MI according frailty. Methods Results All aged ≥75 years first-time during 2002 2021 were identified through Danish nationwide registries. Frailty was categorized using the Hospital Risk Score. One-year risk hazard ratios (HRs) for days...
The evidence for beta-blocker therapy after myocardial infarction (MI) is randomized trials conducted more than 30 years ago, and the continued efficacy has been questioned.
Background— Knowledge about drug–drug interactions commonly arises from preclinical trials, adverse drug reports, or based on knowledge of mechanisms action. Our aim was to investigate whether were discoverable without prior hypotheses using data mining. We focused warfarin–drug as the prototype. Methods and Results— analyzed altered prothrombin time (measured international normalized ratio [INR]) after initiation a novel prescription in previously INR-stable warfarin-treated patients with...
Aim Warfarin is a cornerstone for the prevention of thromboembolism in atrial fibrillation (AF), and several efforts have been taken to increase its usage safety, including risk stratification schemes. Our aim was investigate temporal trends initiation warfarin effects on incidence bleeding patients with new-onset 1996–2011. Methods All first-time diagnosis non-valvular were identified from nationwide administrative registries. Trends determined by linear regression. Results In total 153,682...
We investigated temporal trends in major cardiovascular events following first-time myocardial infarction (MI) and revascularization pharmacotherapy from 2000 to 2017.Using nationwide registries, we identified 120 833 Danish patients with a MI between 2017. 30-day 1-year mortality the risk of admission for heart failure (HF) recurrent MI. Patients were younger higher prevalence hypertension diabetes 2015-2017 compared 2000-2002. The predominantly male (65.6%), median age declined by 3 years...
Over the past decades, there have been improvements in management of cardiovascular (CV) disease and risk factors. Long-term contemporary data on population-level incidence myocardial infarction (MI), heart failure (HF), CV mortality patients with peripheral artery (PAD) are sparse, which we aim to investigate this study.Danish nationwide registers were used identify all aged ≥18 years, first diagnosis PAD between 1997 2016. Age-standardized rates (IRs) per 1000 person-years calculated...
To assess whether anthropometric measures (body mass index [BMI], waist-hip ratio [WHR], and estimated fat [EFM]) are independently associated with major adverse cardiovascular events (MACE), to their added prognostic value compared serum total-cholesterol. The study population comprised 109,509 individuals (53% men) from the MORGAM-Project, aged 19-97 years, without established disease, not on antihypertensive treatment. While BMI was reported in all, WHR EFM were ∼52,000 participants....
Increasing parity is associated with an increased risk of ischemic heart disease (IHD) and stroke in women. This probably attributable to biological responses pregnancy. Male cells presumed fetal origin are commonly present women years after pregnancy-a phenomenon termed male-origin microchimerism (MOM). In this study, we investigated whether MOM was IHD We evaluated the association between events a cohort 766 Danish enrolled Diet, Cancer Health during 1993-1997 when aged 50-64 years. Of...
Background Guideline-based cardioprotective medical therapy is intended to reduce the burden of adverse cardiovascular and limb outcomes in patients with peripheral artery disease (PAD). However, contemporary data describing trends use medication remains limited. The present study, therefore, aims investigate changes PAD. Methods Results By using Danish national healthcare registries, we identified all first-time diagnosis PAD (1997-2016) classified them into two groups: (1) PAD+ that...
Abstract Background Influenza vaccination protects against morbidity and mortality in patients with cardiovascular disease (CVD). We aimed to describe influenza vaccine uptake CVD a universal-access healthcare system. Methods Using nationwide Danish registries, we included all prevalent CVD, defined as heart failure (HF), atrial fibrillation (AF), ischemic (IHD), or stroke during three consecutive seasons (October–December 2017–2019). The outcome was relative frequency of across strata...