A5004055692- Ophthalmology and Eye Disorders
- Pituitary Gland Disorders and Treatments
- Thyroid Disorders and Treatments
- Glaucoma and retinal disorders
- Thyroid Cancer Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Diabetes and associated disorders
- Cardiovascular Syncope and Autonomic Disorders
- Adrenal Hormones and Disorders
- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Sympathectomy and Hyperhidrosis Treatments
- Neuroendocrine Tumor Research Advances
- T-cell and B-cell Immunology
- IgG4-Related and Inflammatory Diseases
- Thyroid and Parathyroid Surgery
- Microscopic Colitis
- Digestive system and related health
- Celiac Disease Research and Management
- Immunodeficiency and Autoimmune Disorders
- Bone health and osteoporosis research
- Effects and risks of endocrine disrupting chemicals
- Immune Cell Function and Interaction
- Advanced Differential Geometry Research
- Intraperitoneal and Appendiceal Malignancies
Wroclaw Medical University
2024
Medical University of Warsaw
2014-2023
Endocrinology Research Center
2007
Graves' orbitopathy (GO) is the main extrathyroidal manifestation of disease (GD). Choice treatment should be based on assessment clinical activity and severity GO. Early referral to specialized centers fundamental for most patients with Risk factors include smoking, thyroid dysfunction, high serum level thyrotropin receptor antibodies, radioactive iodine (RAI) treatment, hypercholesterolemia. In mild active GO, control risk factors, local treatments, selenium (selenium-deficient areas) are...
Background Graves’ orbitopathy (GO) is subject to epidemiological and care-related changes. Aim of the survey was identify trends in presentation GO European Group On Orbitopathy (EUGOGO) tertiary referral centres initial management over time. Methods Prospective observational multicentre study. All new referrals with diagnosis within September–December 2019 were included. Clinical demographic characteristics, timelines therapeutic decisions recorded. Data compared a similar EUGOGO performed...
OBJECTIVE: The development and severity of Graves' ophthalmopathy (GO) may result from a complex interplay genetic environmental factors. aim this study was to investigate the association cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) gene polymorphism non-genetic factors (age, sex, cigarette smoking) with GO in two different populations, Polish-Caucasians Japanese. DESIGN: We investigated distribution CTLA-4 A49G 264 Caucasian patients disease (GD), which 95 had clinically evident...
To evaluate the effectiveness of methylprednisolone (MP) and surgical treatment in achieving complete reversal dysthyroid optic neuropathy (DON) predictive factors this therapy.The group consisted 10 patients (18 eyes) with DON. The diagnosis DON was based on at least two criteria from following: (i) deterioration visual acuity (VA< 1.0), (ii) loss colour vision, (iii) disc swelling, and/or (iv) signs magnetic resonance imaging (presence apical crowding nerve stretching). A recovery defined...
Summary Background Despite great progress, the genetic basis of Graves' disease ( GD ) remains poorly understood. Recently, a population‐based genomewide association study GWAS identified five novel loci ATXN 2/ SH 2B3, MAGI 3, BACH 2, TPO and KALRN as significantly associated with presence thyroid peroxidase autoantibodies TPOA bs), whereas several other showed suggestive association. Methods In this study, we investigated 16 single nucleotide polymorphisms SNP s) bs for susceptibility to...
Differentiating between dysthyroid optic neuropathy (DON), which requires urgent therapy to prevent blindness, and moderate-to-severe Graves orbitopathy (GO) remains challenging. There is no pathognomonic feature of DON in either ophthalmological or radiological examinations.Our aim was investigate the prevalence signs magnetic resonance imaging (MRI) patients with very severe GO.Two researchers reassessed MRI scans 23 consecutive (46 eyes) active, GO 14 (23 GO. Typical include apical...
Abstract Recently Chu et al. conducted a two‐stage genome wide association study in Chinese that identified novel X‐linked Graves' disease ( GD ) susceptibility marker at rs3827440 – nonsynonymous P162S nucleotide transition 519C <T) within G protein‐coupled receptor 174 GPR174 gene. We aimed to replicate this finding Caucasians. Using the TaqMan approach we typed 560 patients from Warsaw and 196 Gliwice as well ethically matched controls N = 748, 198, respectively). found an of T allele...
As nonclassic congenital adrenal hyperplasia (NCCAH) needs to be taken into account in women with hyperandrogenism, we aimed assess whether the recommended level of poststimulated 17OHP ≥30 nmol/l confirms NCCAH.Forty, consecutive biochemical and/or clinical hyperandrogenism (aged 25·4, 18-38) suspected having NCCAH were recruited study. In patients between 5·1 and 29·9 an ACTH stimulation test was performed. basal or nmol/l, twenty-four-hour urinary steroid profile (USP) analysis performed...
To assess the clinical usefulness of European Thyroid Imaging and Reporting Data System (EU-TIRADS) in valuation thyroid nodules malignancy reference to post-surgery histological results.Pre-operative ultrasound was performed consecutive patients admitted for surgery between June 2017 January 2018. were classified according EU-TIRADS five groups: 1-5. At least one fine-needle aspiration biopsy (FNAB)/patient (dominant or suspected nodule) an outpatient clinic. The final diagnosis based on...
Bisphenols (BPs) are commonly known plastifiers that widely used in industry. The knowledge about the impact of BPs on thyroid function is scarce. Proper functioning especially important for women reproductive age, as hypothyroidism affects fertility, pregnancy outcomes and offspring. There no studies analyzing influence volume non-pregnant young women. aim this cross-sectional study was to evaluate relationship between bisphenol A its 10 analogs (BPS, BPC, BPE, BPF, BPG, BPM, BPP, BPZ,...
Adrenalectomy with preoperative pharmacological preparation is strongly recommended in patients diagnosed pheochromocytoma, order to prevent perioperative complications.To compare phenoxybenzamine (PhB) and doxazosin (DOX) terms of haemodynamic status who have been prepared for adrenalectomy.Retrospective analysis 44 pheochromocytoma (aged 16-80 years, 29 females) underwent adrenalectomy. Patients were divided into two groups: 35 on DOX nine PhB.Mean time surgery was 38.8 days the group 18.3...
To investigate whether a polymorphism in the ESR2 gene (rs4986938, previously associated with endometriosis, ovulatory dysfunction and premature onset of coronary heart disease) increases risk Graves' disease (GD).A cohort 375 GD patients (300 females 75 males) 1001 individuals representative background population Poland (502 males 499 females) were genotyped for rs4986938 using allele-specific polymerase chain reaction (PCR).We found an increased frequency A allele among vs. controls...
Venous thromboembolic events (VTE), with their life-threatening manifestation as pulmonary embolism, are potential adverse effects of intravenous methylprednisolone (IVMP) pulse therapy, partially due to a hypercoagulable state. The aim the study was analyze influence IVMP on selected hemostatic parameters in patients moderate-to-severe Graves' orbitopathy (GO).26 euthyroid GO were treated 12 pulses (6 × 0.5, 6 0.25 g every week). Hemostatic variables [factor (F) II, FV, FVII, FVIII,...
Iodinated contrast media (ICM)-induced hyperthyroidism is an underestimated, potentially severe condition; however, its prevention has not been sufficiently investigated. The aim of this study was to evaluate the influence ICM on thyroid status, advantages prophylactic therapy for iodine-induced (IIH) in patients with euthyroid goiter and cardiovascular comorbidities, association between incidence IIH volume.
Intravenous methylprednisolone (IVMP) pulse therapy is the first-line treatment in active moderate-to-severe Graves' orbitopathy (GO) and dysthyroid optic neuropathy (DON). One of adverse effects this liver dysfunction that can be mild (ALT < 100 U/L), moderate (ALT: 100-300 severe defined as acute injury (ALI) > 300 U/L). ALI irreversible fatal. The aim study was to evaluate influence two different schemes with IVMP GO DON on biochemical parameters. 49 patients were treated every week...
Therapy with intravenous glucocorticoids (GCs) is associated various side effects, however, the impact on bone remains elusive. Trabecular score (TBS) a diagnostic tool providing information microarchitecture based images obtained from dual-energy X-ray absorptiometry. We investigated influence of methylprednisolone (IVMP) pulse administration TBS in patients moderate-to-severe Graves' orbitopathy (GO).Fifteen GO were treated 12 IVMP pulses (6x0.5g, 6x0.25 g weekly schedule). They received...
The COVID-19 pandemic affected the health of millions people, both directly through infection and indirectly delayed diagnosis treatment non-COVID-19 illnesses. aim this study was to check impact on appendicitis in children.
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Bluszcz G, Bednarczuk T, Bartoszewicz Z, et al. Clinical utility of TSH receptor antibody levels in Graves’ orbitopathy: a comparison two immunoassays. Central European Journal Immunology. 2018;43(4):405-412. doi:10.5114/ceji.2018.80224. APA Bluszcz, G., Bednarczuk, T., Bartoszewicz, Z., Kondracka, A., Walczak, K., & Żurecka, Z. (2018). Immunology, 43(4), 405-412. https://doi.org/10.5114/ceji.2018.80224 Chicago...
Genes related to the nuclear factor-kappaB (NF-kappaB), a key transcription factor involved in regulation of immune responses, are interesting candidates for association studies autoimmune disorders. The aim this study was investigate an polymorphisms two genes encoding NF-kappaB inhibitors: IKBL (encoding inhibitor kappaB-like) and NFKBIA kappaB alpha), withsusceptibility phenotype Graves' disease (GD).A population-based, case-control comprising 481 patients with GD 455 healthy controls...
Graves' orbitopathy (GO) is the commonest extrathyroidal feature of disease. For active, moderate to severe GO intravenous glucocorticoid pulse therapy (ivGCS) first-line treatment, which might be followed by oral therapy. Glucocorticoid especially in time withdrawal, carries a risk adrenal insufficiency. The aim this study was assess pituitary-adrenal axis function patients with before and at cessation ivGCS, after further therapy.Twenty received treatment accordance EUGOGO protocol (500 mg...