A5103141315- Diabetes and associated disorders
- Pediatric Urology and Nephrology Studies
- Thyroid Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Urological Disorders and Treatments
- Autoimmune Bullous Skin Diseases
- Peroxisome Proliferator-Activated Receptors
- Renal and Vascular Pathologies
- Atherosclerosis and Cardiovascular Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Urticaria and Related Conditions
- T-cell and B-cell Immunology
- Sphingolipid Metabolism and Signaling
- Ophthalmology and Eye Disorders
- Prostate Cancer Diagnosis and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Bladder and Urothelial Cancer Treatments
- Adipose Tissue and Metabolism
- Bone Metabolism and Diseases
- RNA modifications and cancer
- Aldose Reductase and Taurine
- Immunodeficiency and Autoimmune Disorders
- Cancer, Lipids, and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Spinal Dysraphism and Malformations
Indiana University – Purdue University Indianapolis
2017-2025
Riley Hospital for Children
2021-2025
Indiana University Health
2021-2025
Université Bourgogne Franche-Comté
2025
Medical University of Warsaw
2013-2023
RWTH Aachen University
2023
Indiana University School of Medicine
2018-2021
McGill University
2010-2013
Montreal Children's Hospital
2012
Charité - Universitätsmedizin Berlin
2012
Measuring the health related quality of life patients with prostate cancer in routine clinical practice is hindered by lack instruments enabling efficient, real-time, point care scoring multiple domains. Thus, we developed an instrument for this purpose.The Expanded Prostate Cancer Index Composite Clinical Practice a 1-page, 16-item questionnaire that constructed to measure urinary incontinence, irritation, and bowel, sexual hormonal We eliminated conceptually overlapping items from 3-page...
The presented comprehensive review of current knowledge about genetic factors predisposing to Graves disease (GD) put emphasis on functional significance observed associations. In particular, we discuss recent efforts aimed at refining diseases associations found within the HLA complex and implicating class I as well HLADPB1 loci. We summarize data regarding non-HLA genes such PTPN22, CTLA4, CD40, TSHR TG which have been extensively studied in respect their role GD. findings variants FCRL3...
Screening for vesicoureteral reflux in asymptomatic infants with low grade hydronephrosis is unjustified if this condition benign. We present a cohort prenatally detected hydronephrosis, some observed without voiding cystourethrography, and compare outcomes to classic, screened group.A total of 206 consecutive children presenting postnatally confirmed (47% bilateral) were included the study. Cases associated renal or bladder anomalies excluded. Children either underwent screening...
Stearoyl-CoA desaturase (SCD), a rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids, has recently been shown to be critical control point regulation liver and skeletal muscle metabolism. Herein, we demonstrate that endurance training significantly increases both SCD1 mRNA protein levels soleus muscle, whereas it does not affect expression EDL liver. Desaturation index (18:1Δ9/18:0 ratio), an indirect indicator activity, was also higher (3.6-fold) trained rats compared...
Background Two signalling molecules that are attractive for targeted therapy the epidermal growth factor receptor (EGFR) and peroxisome proliferator-activated gamma (PPARγ). We investigated possible crosstalk between these 2 pathways, particularly in light of recent evidence implicating PPARγ anticancer therapy. Principal Findings As evaluated by MTT assays, gefitinib (EGFR inhibitor) DIM-C (PPARγ agonist) inhibited 9 bladder cancer cell lines a dose-dependent manner but with variable...
Summary Background Despite great progress, the genetic basis of Graves' disease ( GD ) remains poorly understood. Recently, a population‐based genomewide association study GWAS identified five novel loci ATXN 2/ SH 2B3, MAGI 3, BACH 2, TPO and KALRN as significantly associated with presence thyroid peroxidase autoantibodies TPOA bs), whereas several other showed suggestive association. Methods In this study, we investigated 16 single nucleotide polymorphisms SNP s) bs for susceptibility to...
Study Type – Therapy (retrospective cohort) Level of Evidence 3a What's known on the subject? and What does study add? It is that majority (80%) solid renal masses are malignant. Most literature suggests smaller tumour size associated with a higher incidence benign disease. We have confirmed decreased disease, particularly for lesions <2 cm. Once radiologically apparent angiomyolipomas excluded, disease small lower than reported in (11%). Furthermore, we shown females association Patient...
Abstract Recently Chu et al. conducted a two‐stage genome wide association study in Chinese that identified novel X‐linked Graves' disease ( GD ) susceptibility marker at rs3827440 – nonsynonymous P162S nucleotide transition 519C <T) within G protein‐coupled receptor 174 GPR174 gene. We aimed to replicate this finding Caucasians. Using the TaqMan approach we typed 560 patients from Warsaw and 196 Gliwice as well ethically matched controls N = 748, 198, respectively). found an of T allele...
Dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis leads to impaired stress response. FK506-binding protein 51 (FKBP5), which influences HPA activity via glucocorticoid receptors, is supposed play an important role in regulation negative feedback and resistance. Since ineffective response mechanisms are considered as a biological background suicide behavior, we aimed analyze possible association between FKBP5 functional polymorphisms completed suicide.The selected rs1360780...
Objectives To confirm the association of previously discovered psoriasis (Ps) risk loci with disease in a Polish population and to create predictive models based on combination these single nucleotide polymorphisms (SNPs). Material methods Thirty-eight SNPs were genotyped 480 Ps patients 490 controls. Alleles distributions compared between controls, as well different sub-phenotypes. The genetic score (GRS) was calculated assess cumulative conferred by multiple loci. Results We confirmed...
Genetic factors are known to influence sport performance. The aim of the present study was assess genetic variants in genes coding for proteins potentially modulating activity brain emotion centres a group 621 elite athletes (212 endurance, 183 power and 226 combat athletes) 672 sedentary controls. Ten statistically significant were identified encoding elements serotoninergic, catecholaminergic hypothalamic-pituitary-adrenal systems different groups. Of those rs860573 variant FEV gene...
Graves' orbitopathy (GO) as well disease (GD) hyperthyroidism originate from an autoimmune reaction against the common auto-antigen, thyroid-stimulating hormone receptor (TSHR). GO phenotype is associated with environmental risk factors, mainly nicotinism, genetic factors which initiate immunologic reaction. In some patients observed before diagnosis of GD hyperthyroidism, while it can also be far after diagnosis. The intensity symptoms varies greatly in these patients. Thus, pathogenesis...
Objective The risk of cardiovascular disease is increased in systemic lupus erythematosus (SLE). A meta-analysis showed carotid intima media thickness (IMT) SLE. aim this study was to assess the infl uence diff erent SLE characteristics and treatment regimens on IMT atherosclerotic plaques.Methods results One hundred three patients 95 age- sex-matched control subjects were included study. measured common arteries bilaterally. Common arteries, internal superfi cial femoral also screened for...
Recently Chu et al. conducted a genome‐wide association study in Chinese Han population and identified two novel Graves' disease (GD) susceptibility loci within 4p14 (rs6832151) 6q27 (rs9355610). Our purpose was to replicate these associations Polish Caucasian population. We analyzed rs6832151 rs9355610 genotypes case‐control based on 560 GD patients 1475 unrelated controls using TaqMan assays. had the power of 0.8 0.6 detect effects originally reported for rs9355610, respectively. found an...
Graves' disease (GD) is an autoimmune thyroid (AITD) with a peak incidence between 30 and 50 years of age. Although children adolescents may also develop the disease, genetic background paediatric-onset GD (POGD) remains largely unknown. Here, we looked for similarities differences in risk factors POGD adult-onset (AOGD) as well variants associated age onset.A total 1267 patients 1054 healthy controls were included study. Allele frequencies 40 established suggested GD/AITD (39 SNPs...