A5025640944- Neurogenesis and neuroplasticity mechanisms
- Mesenchymal stem cell research
- Insect and Arachnid Ecology and Behavior
- Tissue Engineering and Regenerative Medicine
- Anesthesia and Neurotoxicity Research
- Glioma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Nerve injury and regeneration
- Plant Reproductive Biology
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- Nanoparticle-Based Drug Delivery
- Advanced MRI Techniques and Applications
- Insect and Pesticide Research
- Plant and animal studies
- Radiopharmaceutical Chemistry and Applications
- MicroRNA in disease regulation
- Lanthanide and Transition Metal Complexes
- Dendrimers and Hyperbranched Polymers
- Phagocytosis and Immune Regulation
- Fossil Insects in Amber
- Collembola Taxonomy and Ecology Studies
- Electrospun Nanofibers in Biomedical Applications
- Fuel Cells and Related Materials
Celon Pharma (Poland)
2023-2025
Johns Hopkins University
2015-2024
University of Maryland, Baltimore
2019-2024
Nicolaus Copernicus University
2022-2023
University of Baltimore
2019-2021
Institute of Pathology Celle
2021
Polish Academy of Sciences
2009-2019
Mossakowski Medical Research Institute, Polish Academy of Sciences
2009-2019
Johns Hopkins Medicine
2016-2019
Sanford Broadway Medical Center
2016
Graves' orbitopathy (GO) is the main extrathyroidal manifestation of disease (GD). Choice treatment should be based on assessment clinical activity and severity GO. Early referral to specialized centers fundamental for most patients with Risk factors include smoking, thyroid dysfunction, high serum level thyrotropin receptor antibodies, radioactive iodine (RAI) treatment, hypercholesterolemia. In mild active GO, control risk factors, local treatments, selenium (selenium-deficient areas) are...
Citicoline (CDPC) is a natural supplement with well-documented neuroprotective effects in the treatment of neurodegenerative diseases. In present study, we sought to exploit citicoline as theranostic agent its inherent chemical exchange saturation transfer (CEST) MRI signal, which can be directly used an guidance drug delivery. Our vitro CEST results showed has two signals at +1 and +2 ppm, attributed exchangeable hydroxyl amine protons, respectively. To facilitate targeted delivery ischemic...
Glioblastoma multiforme (GBM) is the most aggressive and common type of brain cancer. Five-year survival rates are below 12%, even with trimodal therapies. Poor blood–brain barrier (BBB) permeability therapeutics a major obstacle to efficacy. Intravenous administration bevacizumab standard treatment for GBM. It has been recently demonstrated that single intraarterial infusion provides superior therapeutic outcomes in patients recurrent Further GBM benefits can be achieved through opening BBB...
Since the brain is naturally inefficient in regenerating functional tissue after injury or disease, novel restorative strategies including stem cell transplantation and engineering have to be considered. We investigated use of such order achieve better repair outcomes. One fundamental challenges successful delivery cells injured site while maintaining viability. Classical methods intravenous intraparenchymal injections are plagued by low engraftment poor survival transplanted cells. Novel...
The incidence of accidental and intentional acid skin burns is rising. Current treatment strategies are mostly inadequate, leaving victims disfigured without options. Here, we have shown that transplantation adipose-derived stem cells (ASCs) accelerates the process burn wound-healing. Pre-conditioning ASCs using ascorbic (AA) or hypoxic conditions provided additional benefit. While wounds were ultimately healed in all mice, histological analysis revealed that, non-transplanted animals,...
PAMAM dendrimers can serve as scaffolds for dual contrast imaging<italic>in vivo</italic>. Here they target tumors expressing the prostate-specific membrane antigen (PSMA) fluorescence and photoacoustic imaging.
Searching for a reliable source of alternative neural stem cells experimental treatment neurological disorders we have established cell line derived from human umbilical cord blood (HUCB-NSC) (Buzanska et al. 2006). These been shown to differentiate along neuronal and glial lineages in the promoting vitro conditions. In current study transplanted HUCB-NSC into rat brain determine whether progenitors would be able survive, migrate eventually adopt phenotypes after exposure central nervous...
The aim of the study was to evaluate therapeutic effectiveness intra-arterial infusion human umbilical cord blood (HUCB) derived cells at different stages their neural conversion. Freshly isolated mononuclear (D-0), neurally directed progenitors (D-3) and neural-like stem from (NSC) were compared. Focal brain damage induced in rats by stereotactic injection ouabain into dorsolateral striatum Three days later 107 subsets HUCB infused right internal carotid artery. Following surgery housed...
At present, accurate and reliable biomarkers to ascertain the presence, severity, or prognosis of blast traumatic brain injury (bTBI) are lacking. There is an urgent need establish capable mbTBI detection. Currently, there no studies that identify changes in miRNA lipids at varied severities bTBI. Various biological components such as lipids, circulating mRNA, miRNA, could potentially be detected using advanced techniques next-generation sequencing mass spectroscopy. Therefore, plasma...
Mesenchymal stem cell (MSC) transplantation has been explored as a new clinical approach to repair injured tissues. However, in order evaluate the therapeutic activity of MSC, tracking techniques are required determine fate transplanted cells both preclinical and studies. In these aspects, different vital stains offer potential for labeling monitoring grafted vivo. It is desirable have agents which long-term stability, not toxic cells, do affect function.Here, we selected three labels:...
Abstract Background: AXL is a critical regulator in tumor progression, contributing to proliferation, invasiveness, epithelial-mesenchymal transition (EMT), angiogenesis, and immune modulation. High levels are associated with poor prognosis aggressive cancers. Concurrently, PD-L1 can suppress the antitumor immunity by binding PD-1 on cells, pathway already targeted several immunotherapies. However, recent studies indicated that PD-L1's role extends beyond binding. It seems be involved...
The loss of oligodendrocytes after stroke is one the major causes secondary injury. Glial-restricted progenitors (GRPs) have remylenating potential intraparenchymal cerebral transplantation. intraarterial (IA) injection route an attractive gateway for global brain delivery, but, IA infusion, naive GRPs fail to bind vasculature. aim this study was test whether overexpression Very Late Antigen-4 (VLA-4) increases endothelial docking and homing in a model. Mouse were co-transfected with DNA...
Brain tumors are among the most lethal types of tumors. Therapeutic response variability and failure in patients have been attributed to several factors, including inadequate drug delivery due blood-brain barrier (BBB). Consequently, strategies being developed for local targeted drugs brain These could benefit from new approaches monitor Here, we evaluated feasibility imaging 4-[bis(2-chloroethyl)amino]-l-phenylalanine (melphalan), a clinically used DNA alkylating agent, using chemical...
Transplantation of mesenchymal stem cells (MSCs) has emerged as a promising strategy for the treatment myriad human disorders, including several neurological diseases. Superparamagnetic iron oxide nanoparticles (SPION) and fluorine nanoemulsion (19F) are characterized by low toxicity good sensitivity, and, such, among most frequently used cell-labeling agents. However, to date, their impact across various populations MSCs not been comprehensively investigated. Thus, MRI tags (independent...
Stroke is the leading cause of severe disability, and lacunar stroke related to cognitive decline hemiparesis. There no effective treatment for majority patients with stroke. Thus, stem cell-based regenerative medicine has drawn a growing body attention due capabilities trophic factor expression neurogenesis enhancement. Moreover, it was shown in an experimental autoimmune encephalomyelitis (EAE) model that even short-lived cells can be therapeutic, we have previously observed phenomenon...
Prostate cancer (PC) is the second most common and fifth frequent cause of death among men. Prostate-specific membrane antigen (PSMA) expression associated with aggressive PC, in over 90% patients metastatic disease. Those characteristics have led to its use for PC diagnosis therapies radiopharmaceuticals, antibody-drug conjugates, nanoparticles. Despite these advancements, none current therapeutics are curative show some degree toxicity. Here we present synthesis preclinical evaluation a...