A5020690169- Ophthalmology and Eye Disorders
- Facial Rejuvenation and Surgery Techniques
- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Botulinum Toxin and Related Neurological Disorders
- Intraocular Surgery and Lenses
- Nasolacrimal Duct Obstruction Treatments
- Ocular Infections and Treatments
- Cerebral Venous Sinus Thrombosis
- Pituitary Gland Disorders and Treatments
- Facial Nerve Paralysis Treatment and Research
- Corneal surgery and disorders
- Facial Trauma and Fracture Management
- Trigeminal Neuralgia and Treatments
- Thyroid Disorders and Treatments
- Retinal and Optic Conditions
- Reconstructive Facial Surgery Techniques
- Dermatologic Treatments and Research
- Sinusitis and nasal conditions
- Corneal Surgery and Treatments
- Ophthalmology and Visual Health Research
- Dental Anxiety and Anesthesia Techniques
- Surgical Simulation and Training
- Ocular Disorders and Treatments
- Traumatic Ocular and Foreign Body Injuries
University College London
2015-2024
Moorfields Eye Hospital
2015-2024
Moorfields Eye Hospital NHS Foundation Trust
2015-2024
Federal Medical Centre
2024
London Clinic
2022-2024
Gombe State University
2023
NIHR Moorfields Biomedical Research Centre
2014-2022
UCL Biomedical Research Centre
2013-2020
University College Hospital
2012-2016
National Institute for Health Research
2010-2015
Thyroid-associated ophthalmopathy, a condition commonly associated with Graves' disease, remains inadequately treated. Current medical therapies, which primarily consist of glucocorticoids, have limited efficacy and present safety concerns. Inhibition the insulin-like growth factor I receptor (IGF-IR) is new therapeutic strategy to attenuate underlying autoimmune pathogenesis ophthalmopathy.
Blinking is vital to maintain the integrity of ocular surface and its characteristics such as blink duration speed can vary significantly, depending on health eyes. The so rapid that special techniques are required characterize it. In this study, a high-speed camera was used record voluntary blinking. blinking motion 25 healthy volunteers recorded at 600 frames per second. Master curves for palpebral aperture were constructed using versus time data taken from recordings, which show one be...
Abstract Context Gut bacteria can influence host immune responses but little is known about their role in tolerance-loss mechanisms Graves disease (GD; hyperthyroidism caused by autoantibodies, TRAb, to the thyrotropin receptor, TSHR) and its progression orbitopathy (GO). Objective This work aimed compare fecal microbiota GD patients, with GO of varying severity, healthy controls (HCs). Methods Patients were recruited from 4 European countries (105 41 HCs) for an observational study...
Objective: Many patients are satisfied with their ocular prosthesis, but some describe problems social interactions, body image and self-esteem. Although both clinical practice research suggest that the severity of a disfiguring condition does not predict distress, there has been little living an prosthesis. The objective was to explore psychological impact artificial eye or cosmetic shell determine relationship between well-being psychosocial factors.Methods: A cross-sectional study March...
To explore the factors associated with mood and quality of life (QoL) patients strabismus due to undergo realignment surgery.A cross-sectional study was undertaken adult patients. Along demographic, clinical psychosocial process variables, Hospital Anxiety Depression Scale AS-20 QoL measures were administered. Regression models used identify mood.Of 220 participants, 11% experiencing levels depression, 24% anxiety. This is in line other forms facial disfigurement but higher than chronic...
Graves' orbitopathy (GO) is uncommon, but responsible for considerable morbidity. A coordinated approach between healthcare professionals required in order to meet the needs of patients. Early diagnosis can be achieved by a simple clinical assessment. Low-cost effective interventions initiated generalists, which may improve outcomes. Moderate-to-severe GO should referred specialised centres. Recommendations diagnosis, initial management and referral pathways are highlighted.
Floppy eyelid syndrome (FES) is an acquired hyperelasticity disorder affecting the upper eyelid. The tarsal plate becomes hyperelastic with a loss of intrinsic rigidity. As result, subjected to cyclic mechanical stress. This condition was used as model investigate changes in dynamic fibroblast contractility context chronic
Abstract Purpose Abnormalities of lacrimal punctum size and morphology probably contribute to excess tearing, with significant effects on quality‐of‐life for affected individuals. Our current understanding normal punctal originates from ex vivo studies, which are unlikely capture the true nature living punctum. This study used enhanced depth anterior segment optical coherence tomography ( OCT ) give improved characterization structure. Methods Qualitative quantitative assessments were...
Trachoma is a conjunctival scarring disease, which the leading infectious cause of blindness worldwide. Elimination blinding trachoma being held back by high rate trichiasis recurrence following surgery. There currently no treatment available to suppress profibrotic state and reduce recurrence. Although mechanisms underlying development are unknown, phenotype has been linked matrix metalloproteinase (MMP) expression. Doxycycline, well-known tetracycline antibiotic, can act as broad MMP...
The generalizability of findings Randomised Controlled Trials (RCTs) is undermined by low or biased recruitment. Reasons for participant refusal are infrequently reported in published literature.To apply the Theoretical Framework Acceptability (TFA) to: (1) explore patient-reported reasons declining to participate a RCT comparing new service model (patient-initiated appointments) with standard care (appointments scheduled clinician) managing blepharospasm and hemifacial spasm; (2)...
Background: Hyaluronic acid dermal fillers are used extensively in periocular aesthetic medicine, and the incidence of filler-related complications is increasing. This study aimed to investigate optimal dosing strategy for hyaluronidase identify predictors poor outcomes. Methods: We performed a retrospective review 157 orbits 90 patients treated with over 4-year period. Demographic data, indication, details treatment outcomes were recorded. Results: The primary indication dissolving filler...