A5057003705- Retinal Development and Disorders
- Bat Biology and Ecology Studies
- Optical Coherence Tomography Applications
- Animal Ecology and Behavior Studies
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Circadian rhythm and melatonin
- Ophthalmology and Visual Impairment Studies
- Retinal Imaging and Analysis
- Neuroscience and Neuropharmacology Research
- Retinopathy of Prematurity Studies
- Neuroscience and Neural Engineering
- Neurobiology and Insect Physiology Research
- CRISPR and Genetic Engineering
- Physiological and biochemical adaptations
- Adipokines, Inflammation, and Metabolic Diseases
- Infrared Thermography in Medicine
- Sleep and related disorders
- Adipose Tissue and Metabolism
- Sleep and Work-Related Fatigue
Medical College of Wisconsin
2020-2025
University of Wisconsin–Oshkosh
2021
Visual Sciences (United States)
2020
Hershey (United States)
2004
Total sleep restriction in humans is associated with increased daytime sleepiness, decreased performance, and hormonal/metabolic disturbances. The effects of mild chronic that mimic real life are not known. To assess the modest from 8 to 6 h/night for 1 wk, 25 young, healthy, normal sleepers (12 men 13 women) were studied 12 consecutive nights laboratory. After wk restriction, although subjects' nighttime was deeper, subjects significantly sleepier (multiple latency test) performed worse...
Several retinal degenerations affect the human central retina, which is primarily comprised of cones and essential for high acuity color vision. Transplanting cone photoreceptors a promising strategy to replace degenerated in this region. Although approach has been investigated handful animal models, commonly used rodent models lack cone-rich region larger can be expensive inaccessible, impeding translation therapies. Here, we transplanted dissociated GFP-expressing from organoids...
Purpose: Achromatopsia (ACHM) is an autosomal recessive retinal disease associated with reduced or absent cone function. There debate regarding the extent to which structure shows progressive degeneration in patients ACHM. Here, we used optical coherence tomography (OCT) images evaluate outer nuclear layer (ONL) thickness and ellipsoid zone (EZ) integrity over time individuals Methods: Sixty-three genetically confirmed ACHM follow-up ranging from about 6 months 10 years were imaged using...
Abstract Animal models of retinal degeneration are critical for understanding disease and testing potential therapies. Inducing commonly involves the administration chemicals that kill photoreceptors by disrupting metabolic pathways, signaling or protein synthesis. While chemically induced has been demonstrated in a variety animals (mice, rats, rabbits, felines, 13-lined ground squirrels (13-LGS), pigs, chicks), few studies have used noninvasive high-resolution imaging to monitor vivo...
To examine whether time of year (relative to hibernation emergence) influences the retinal degenerative effects intravitreal injection adenosine triphosphate (ATP) in 13-lined ground squirrel (13-LGS).
To mitigate the substantial post-processing burden associated with adaptive optics scanning light ophthalmoscopy (AOSLO), we have developed an open-source, automated AOSLO image processing pipeline both “live” and “full” modes. The live mode provides feedback during acquisition, while full is intended to automatically integrate copious disparate modules currently used in generating analyzable montages. mean (±SD) lag between initiation montage placement for was 54.6 ± 32.7s. reduced overall...
images of human cone photoreceptors have been shown to vary in their reflectance both spatially and temporally. While it is generally accepted that the unique anatomy physiology themselves drives this behavior, exact mechanisms not fully elucidated as most studies on these phenomena limited retina. Unlike humans, animal models offer ability experimentally manipulate retina perform direct
An adaptive optics scanning light ophthalmoscope was enhanced with a Dove prism to obtain arbitrary angle split-detection images. This application allows for low-cost enhancement of extant systems and facilitates the resolution retinal features.