A5085044840- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Amino Acid Enzymes and Metabolism
- Pomegranate: compositions and health benefits
- Occupational and environmental lung diseases
- Sulfur Compounds in Biology
- Bladder and Urothelial Cancer Treatments
- Cancer Cells and Metastasis
- Peroxisome Proliferator-Activated Receptors
- Metabolism, Diabetes, and Cancer
- Gastric Cancer Management and Outcomes
- Growth Hormone and Insulin-like Growth Factors
- Apelin-related biomedical research
- Curcumin's Biomedical Applications
- Genomics, phytochemicals, and oxidative stress
- Mycotoxins in Agriculture and Food
- Bioactive Compounds and Antitumor Agents
- Advanced Proteomics Techniques and Applications
- Lipid metabolism and biosynthesis
- Glioma Diagnosis and Treatment
- Kruppel-like factors research
- Eicosanoids and Hypertension Pharmacology
- Virus-based gene therapy research
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
Medical University of Lodz
2011-2023
AGH University of Krakow
2013
Southern Taiwan University of Science and Technology
2013
Wellcome Trust
2013
Medical Research Council
2013
Cancer Research UK
2013
Cancer Genetics (United States)
2013
Barts Health NHS Trust
2013
St Bartholomew's Hospital
2013
Queen Mary University of London
2013
Targeted therapies have yet to significant impact on the survival of patients with bladder cancer. In this study, we focused urea cycle enzyme argininosuccinate synthetase 1 (ASS1) as a therapeutic target in cancer, based our discovery prognostic and functional import ASS1 setting. expression status tumors from 183 Caucasian 295 Asian was analyzed, along its hypothesized association clinicopathologic features, including tumor size invasion. Furthermore, genetics, biology, implications loss...
Thymidylate synthase (TYMS) is the crucial enzymatic precursor for DNA biosynthesis and, therefore, critical target numerous types of chemotherapy, including most frequently applied agent in colon cancer treatment 5-fluorouracil (5-FU). TYMS also seems to be associated with metastasis and acquiring mesenchymal character by tumor cells during epithelial–mesenchymal transition (EMT). Based on that knowledge, we decided investigate role modulation invasive ability cells, where its effect has...
Extracts from the defatted evening primrose (Oenothera paradoxa Hudziok) seeds are source of a range stable polyphenolic compounds, including ellagic acid, gallic and catechin. Our studies evaluate, for first time, influence isopropanol extract (EPE) on malignant pleural mesothelioma (MPM) cells. MPM is rarely diagnosed, its high aggressiveness frequently noted chemoresistance limit treatment schemes it characterized by low prognostic features. Here, we demonstrate that EPE inhibited growth...
Natural polyphenols are plant metabolites exhibiting a broad range of biological activities. Among them, anticancer properties seem to be very desirable. This study examined the and anti-metastatic polyphenol-rich extract from evening primrose seeds (EPE). In vitro in vivo studies performed colorectal cancer (CRC) cell lines AOM-DSS-induced colitis-associated colon mice revealed EPE properties. Furthermore, we studied activity on metastatic abilities showed that inhibited invasiveness...
Purpose: To determine the mechanism of EPE in downregulating TYMS MPM cancer. Methods: The mRNA expression with epithelial-to-mesenchymal transition biomarkers and nuclear factor SP1 was assessed using GEO database a data set patients (GSE51024). Invasive cell lines were vitro models for investigation after treatment. tyms promoter binding sequences determined Genomatix v 3.4 software Electrophoretic mobility shift dual-luciferase reporter assays revealed specific motifs interaction...
Abstract Tumors deficient in argininosuccinate synthetase-1 (ASS1), a key enzyme involved arginine synthesis, are auxotrophic for and sensitive to amino acid deprivation. Currently, several trials testing the arginine-depleting agent, pegylated deiminase (ADI-PEG20) patients with cancer, including randomised phase II multicenter UK study ASS1-deficient mesothelioma (NCT01279967). Here, we sought identify pathways mechanism of action ADI-PEG20 using panel malignant (MPM) cell lines as our...
<p>PDF file - 408K, Pyrosequencing data of bladder cancer cell lines and primary samples.</p>
<p>PDF file - 65K</p>
<p>PDF file - 65K</p>
<div>Abstract<p>Targeted therapies have yet to significant impact on the survival of patients with bladder cancer. In this study, we focused urea cycle enzyme argininosuccinate synthetase 1 (ASS1) as a therapeutic target in cancer, based our discovery prognostic and functional import ASS1 setting. expression status tumors from 183 Caucasian 295 Asian was analyzed, along its hypothesized association clinicopathologic features, including tumor size invasion. Furthermore, genetics,...
<p>PDF file - 802K, Metabolomics of ADI-PEG20 in a corroborative cell line panel (mesothelioma).</p>
<p>PDF file - 408K, Pyrosequencing data of bladder cancer cell lines and primary samples.</p>
<p>PDF file - 315K, Immunostaining of ASS1, TS, and DHFR in representative urothelial carcinomas.</p>
<p>PDF file - 177K, Kaplan-Meier plot and log-rank test for disease-specific metastasis-free survival.</p>
<p>PDF file - 802K, Metabolomics of ADI-PEG20 in a corroborative cell line panel (mesothelioma).</p>
<div>Abstract<p>Targeted therapies have yet to significant impact on the survival of patients with bladder cancer. In this study, we focused urea cycle enzyme argininosuccinate synthetase 1 (ASS1) as a therapeutic target in cancer, based our discovery prognostic and functional import ASS1 setting. expression status tumors from 183 Caucasian 295 Asian was analyzed, along its hypothesized association clinicopathologic features, including tumor size invasion. Furthermore, genetics,...
<p>PDF file - 315K, Immunostaining of ASS1, TS, and DHFR in representative urothelial carcinomas.</p>