A5112177172- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Ovarian cancer diagnosis and treatment
- Amino Acid Enzymes and Metabolism
- Advanced Breast Cancer Therapies
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- CRISPR and Genetic Engineering
- Microtubule and mitosis dynamics
- DNA Repair Mechanisms
- Bladder and Urothelial Cancer Treatments
- Sulfur Compounds in Biology
- MicroRNA in disease regulation
- Radiopharmaceutical Chemistry and Applications
- Molecular Biology Techniques and Applications
- Glutathione Transferases and Polymorphisms
- Retinal Diseases and Treatments
- Pluripotent Stem Cells Research
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- Receptor Mechanisms and Signaling
- BRCA gene mutations in cancer
- Down syndrome and intellectual disability research
- Neuropeptides and Animal Physiology
BenevolentAI (United Kingdom)
2023-2025
Horizon Discovery (United Kingdom)
2017-2018
Case Western Reserve University
2016
Queen Mary University of London
2013-2014
Medical Research Council
2013
Cancer Research UK
2013
Southern Taiwan University of Science and Technology
2013
Wellcome Trust
2013
Cancer Genetics (United States)
2013
Barts Health NHS Trust
2013
Targeted therapies have yet to significant impact on the survival of patients with bladder cancer. In this study, we focused urea cycle enzyme argininosuccinate synthetase 1 (ASS1) as a therapeutic target in cancer, based our discovery prognostic and functional import ASS1 setting. expression status tumors from 183 Caucasian 295 Asian was analyzed, along its hypothesized association clinicopathologic features, including tumor size invasion. Furthermore, genetics, biology, implications loss...
// Chantelle D. Hudson 1 , Alyssa Savadelis Anil Belur Nagaraj 2 Peronne Joseph Stefanie Avril 3 Analisa DiFeo 2, * Norbert 1, Department of Radiology, Case Center for Imaging Research, Western Reserve University, Cleveland, OH 44106, USA Comprehensive Cancer Center, Pathology, Shared senior authors Correspondence to: Avril, email: Norbert.Avril@Case.edu Keywords: ovarian cancer, cisplatin resistance, glutamine metabolism, glutaminase inhibitors Received: February 13, 2016 Accepted: April...
The Brn-3a POU transcription factor is associated with survival and the differentiation of sensory neuronal cells during development. mediates its effects either by direct regulation target genes or indirectly upon interaction proteins such as p53. differentially regulates p53-mediated gene expression modifies effect on cell fate. Here we show that, like Bax, antagonizes another proapoptotic target, Noxa, significantly reducing transactivation Noxa promoter This requires p53 binding site,...
Abstract Up to 90% of high-grade serous ovarian cancer (HGSC) patients will develop resistance platinum-based chemotherapy, posing substantial therapeutic challenges due a lack universally druggable targets. Leveraging BenevolentAI’s AI-driven approach target discovery, we screened potential AI-predicted targets mapped unapproved tool compounds in patient-derived 3D models. This identified TNIK, which is modulated by NCB-0846, as novel for platinum-resistant HGSC. Targeting this compound...
<div>Abstract<p>Up to 90% of patients with high-grade serous ovarian cancer (HGSC) will develop resistance platinum-based chemotherapy, posing substantial therapeutic challenges due a lack universally druggable targets. Leveraging BenevolentAI’s artificial intelligence (AI)–driven approach target discovery, we screened potential AI-predicted targets mapped unapproved tool compounds in patient-derived 3D models. This identified TNIK, which is modulated by NCB-0846, as novel for...
<p>Supplementary Figure S4: Densitometry for 4 western blots</p>
<p>Supplementary Figure S2: Validation of NCB-0846 in selectively targeting platinum-resistant HGSC across cell models.</p>
<p>Supplementary Figure S1: Characterization of OV81-CP40 and OV231-CP30 cell lines results GSEA for RNAseq.</p>
<p>Supplementary Figure S3: Validation of lithium chloride and 3 western blot densitometry</p>
<p>Supplementary Figure S5: CDK9 inhibition shows platinum-resistant HGSC efficacy and specificity mediates responses to enhanced Wnt activity.</p>
<p>Supplementary Figure S6: Inhibition of MYC is important in TNIK and CDK9-mediated targeting efficacy as observed through HEC1B treatment with NCB-0846</p>
Aging is the major risk factor for chronic disease development. Cellular senescence a key mechanism that triggers or contributes to age-related phenotypes and pathologies. The endothelium, single layer of cells lining inner surface blood vessel, critical interface between all tissues. Many studies report link endothelial cell senescence, inflammation, diabetic vascular diseases. Here we identify, using combined advanced AI machine learning, Dual Specificity Tyrosine Phosphorylation Regulated...
AbstractAcute myeloid leukaemia (AML) is the most common acute in adults. Around 10-15% of individuals with recessively inherited Fanconi anaemia (FA) develop AML. FA one a group recessive syndromes characterized by excessive spontaneous chromosomal breakage which heterozygote carriers appear to display an increased risk cancer and there some indirect evidence that may also be at This suggests genes play role development AML wider context. To examine this proposition, further, we have...
Abstract The Brn‐3a transcription factor is critical for survival and differentiation of sensory neurons derived from neural crest cells (NCC). Interaction with p53 results in differential effects on target gene expression, which profoundly affects fate neuronal cells. Here we demonstrate colocalization a subset Brn‐3a‐positive NCC‐derived fated the lineage. distinct morphology Brn‐3a/p53‐coexpressing suggested differentiated cell type, this was confirmed by marker NF‐160. Functional...
Abstract Background Arginine is an important amino acid for tumor cell growth and development. Argininosuccinate synthetase 1 (ASS1) a key enzyme required biosynthesis of arginine. Preclinically, ASS1-deficient cells are particularly sensitive to arginine depletion, randomised trials exploring this strategy in progress hepatocellular carcinoma mesothelioma using the drug pegylated deiminase (ADI-PEG20). In study, we determined metabolic changes induced by ADI-PEG20 treatment panel bladder...
<p>PDF file - 408K, Pyrosequencing data of bladder cancer cell lines and primary samples.</p>