A5068565015- DNA and Nucleic Acid Chemistry
- RNA and protein synthesis mechanisms
- Advanced biosensing and bioanalysis techniques
- Fatty Acid Research and Health
- Phytochemicals and Antioxidant Activities
- Intracerebral and Subarachnoid Hemorrhage Research
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced Glycation End Products research
- Gestational Diabetes Research and Management
- Metabolomics and Mass Spectrometry Studies
- Natural Antidiabetic Agents Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Organophosphorus compounds synthesis
- Intracranial Aneurysms: Treatment and Complications
- Sirtuins and Resveratrol in Medicine
- Hibiscus Plant Research Studies
- Muon and positron interactions and applications
- Lipid metabolism and biosynthesis
- Adipose Tissue and Metabolism
- Genomics, phytochemicals, and oxidative stress
- HIV/AIDS drug development and treatment
- Inorganic and Organometallic Chemistry
- Mycotoxins in Agriculture and Food
- Prenatal Substance Exposure Effects
- Diet, Metabolism, and Disease
Medical University of Lodz
2009-2023
Polish Academy of Sciences
2005-2009
Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk
2005-2009
Gestational diabetes mellitus (GDM) is a disorder which manifests itself for the first time during pregnancy and mainly connected with glucose metabolism. It also known that fatty acid profile changes in erythrocyte membranes plasma could be associated obesity insulin resistance. These factors can lead to development of diabetes. In reported study, we applied untargeted analysis GDM against standard glucose-tolerant (NGT) women identify differences metabolomic profiles between those groups....
Gestational diabetes mellitus (GDM) is a glucose intolerance that begins or first recognized during pregnancy. It currently growing health problem worldwide affecting from 1% to 14% of all pregnant women depending on racial and ethnic group as well the diagnostic screening criteria. Our preliminary study aimed at investigating erythrocyte membrane fatty acid profiles women, in particular with diagnosed gestational (GDM), normal tolerant (NGT) control group. The comprised 43 32 whom were GDM...
In the reported study we applied targeted metabolomic profiling employing high pressure liquid chromatography coupled with triple quadrupole tandem mass spectrometry (HPLC–MS/MS) to understand pathophysiology of gestational diabetes mellitus (GDM), early identification women who are at risk developing GDM, and differences in recovery postpartum between these normoglycemic women. We profiled peripheral blood from patients during second trimester pregnancy three months, one year postpartum....
Although a growing body of evidence suggests that plant polyphenols can modulate human immune responses, their simultaneous action on monocyte and neutrophil oxidative burst is currently poorly understood. Based the hypothesis various contained in extracts might affect phagocytes, we evaluated effects ethanolic O. paradoxa extract vitro activated by different stimuli, including opsonized bacteria E. coli , phorbol 12-myristate 13-acetate (PMA), formyl-methionyl-leucyl-phenylalanine (fMLP)....
Extracts from the defatted evening primrose (Oenothera paradoxa Hudziok) seeds are source of a range stable polyphenolic compounds, including ellagic acid, gallic and catechin. Our studies evaluate, for first time, influence isopropanol extract (EPE) on malignant pleural mesothelioma (MPM) cells. MPM is rarely diagnosed, its high aggressiveness frequently noted chemoresistance limit treatment schemes it characterized by low prognostic features. Here, we demonstrate that EPE inhibited growth...
Abstract The synthesis of protected model dinucleoside (3',5')‐ O ‐aryl phosphorothioates, their separation into pure diastereomers, and successful incorporation oligonucleotides followed by stereospecific deprotection the phosphorothioate function with oximate ion (inversion) enables preparation chimeric PO/PS‐oligonucleotides a predetermined sense P ‐chirality at each internucleotide position. absolute configuration phosphorus in “dimeric building blocks” has been assigned. 3'‐terminal S...
Aneurysmal subarachnoid haemorrhages (aSAH) account for 5% of strokes and continues to place a great burden on patients their families. Cerebral vasospasm (CVS) is one the main causes death after aSAH, usually diagnosed between day 3 14 bleeding. Its pathogenesis remains poorly understood. To verify whether plasma concentration amino acids have prognostic value in predicting CVS, we analysed data from 35 aSAH (median age 55 years, IQR 39-62; 20 females, 57.1%), 37 healthy volunteers 50...
An efficient method for large laboratory scale synthesis of dinucleoside (3′,5′)-methylphosphonothioates and their methylphosphonoselenoate congeners is presented. Bis-(1,2,4-triazoloyl)methylphosphonite generated in situ from methyldichlorophosphine used as a phosphitylating agent the preparations are performed one-pot-reactions without isolation reactive PIII intermediates.
Abstract Stereoregular chimeric oligonucleotides modified with diastereomerically pure methylphosphonothioate linkages interact complementary DNA or RNA templates in a stereodependent manner. There is an unprecedented large difference the stability of duplexes alternating (Δ T m = 34 °C) that dependent only on stereochemistry phosphorus centres. The nature these interactions was studied by circular dichroism and NMR spectroscopy, thermodynamic analysis performed. collected data indicate...