A5034361964- Pancreatic function and diabetes
- Diabetes and associated disorders
- Diabetes Management and Research
- MicroRNA in disease regulation
- Asthma and respiratory diseases
- Endoplasmic Reticulum Stress and Disease
- Metabolism, Diabetes, and Cancer
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Genetics and Neurodevelopmental Disorders
- Cancer Cells and Metastasis
- Diet, Metabolism, and Disease
- Arsenic contamination and mitigation
- IL-33, ST2, and ILC Pathways
- Cancer, Hypoxia, and Metabolism
- Autoimmune and Inflammatory Disorders Research
- Mitochondrial Function and Pathology
- Peptidase Inhibition and Analysis
- Heavy Metal Exposure and Toxicity
- Radiation Therapy and Dosimetry
- Effects of Radiation Exposure
- Prostate Cancer Treatment and Research
- Lymphatic System and Diseases
- Burn Injury Management and Outcomes
- Protein Kinase Regulation and GTPase Signaling
Montefiore Medical Center
2023-2025
Albert Einstein College of Medicine
2020-2025
National Institute of Allergy and Infectious Diseases
2024
Medical University of Lodz
2014-2023
Medical University of Warsaw
2017-2019
Postgraduate School of Molecular Medicine
2017-2019
Harvard University
2019
Pancreatic ductal adenocarcinoma is a notoriously difficult-to-treat cancer and patients are in need of novel therapies. We have shown previously that these tumours altered metabolic requirements, making them highly reliant on number adaptations including non-canonical glutamine (Gln) pathway inhibition downstream components Gln metabolism leads to decrease tumour growth. Here we test whether recently developed inhibitors glutaminase (GLS), which mediates an early step metabolism, represent...
Evolutionarily conserved serum microRNAs predict radiation-induced fatality in nonhuman primates.
Covalent inhibitors of the KRASG12C oncoprotein have recently been developed and are being evaluated in clinical trials. Resistance to targeted therapies is common may limit long-term efficacy KRAS (KRASi). To identify pathways adaptation KRASi predict drug combinations that circumvent resistance, we use mass-spectrometry-based quantitative temporal proteomics profile proteomic response pancreatic lung cancer 2D 3D cellular models. We quantify 10,805 proteins, representing most comprehensive...
Ncoa4 mediates autophagic degradation of ferritin, the cytosolic iron storage complex, to maintain intracellular homeostasis. Recent evidence also supports a role for in systemic homeostasis and erythropoiesis. However, specific contribution temporal importance Ncoa4-mediated ferritinophagy regulating erythropoiesis is unclear. Here, we show that has critical basal both cell autonomous non-autonomous roles murine Using an inducible model knockout, acute disruption impaired leading tissue...
Abstract Background Acute radiation syndrome (ARS) manifests after exposure to high doses of in the instances radiologic accidents or incidents. Facilitating regeneration bone marrow (BM), namely hematopoietic stem and progenitor cells (HSPCs), is key mitigating ARS multi-organ failure. JNJ-26366821, a PEGylated thrombopoietin mimetic (TPOm) peptide, has been shown as an effective medical countermeasure (MCM) treat hematopoietic-ARS (H-ARS) mice. However, activity TPOm on regulating BM...
Triple negative breast cancer (TNBC) has caught the attention of oncologists worldwide because poor prognosis and paucity targeted therapies. Gene pathways have been widely studied, but less is known about epigenetic factors such as microRNAs (miRNAs) their role in tailoring an individual systemic surgical approach for patients. The aim study was to examine selected miRNAs TNBC core biopsies sampled before preoperative chemotherapy subsequent pathologic response mastectomy or conservation...
Arsenic (As) is a known toxic element and carcinogen. Transcription factor nuclear factor-erythroid 2-related 2 (NRF2) controls cellular adaptation to oxidants electrophiles by inducing antioxidant genes in response redox stress. To explore associations between As level NRF2-regulated cytoprotective expression, an observational study was conducted population of 61 occupationally exposed men with median (Me) age 50 years (interquartile range (IQR) 42-54) control group 52 aged 40 (IQR 31-51.5)...
The aim of the study was to determine concentration hexavalent and trivalent chromium, nickel, manganese, iron in welding fumes (WFs) evaluate significant association between metals biological material welders. studies were conducted welders (n = 67) controls 52). Stainless steel WFs continuously collected workers' breathing zone during a shift. serum urine concentrations Cr Ni determined by ICP-MS. content Mn whole blood using ET-AAS. erythrocytes welders' positively correlated with work...
Patients with diabetes caused by single-gene mutations generally exhibit an altered course of diabetes. Those the glucokinase gene (GCK-MODY) show good metabolic control and low risk cardiovascular complications despite paradoxically lowered high-density lipoprotein (HDL) cholesterol levels. In order to investigate matter, we analyzed composition low-density (LDL) HDL subpopulations in such individuals. The LipoPrint(©) system (Quantimetrix, USA) based on non-denaturing, linear...
Platelet hyperreactivity is a factor which contributes towards increased risk of cardiovascular events in adults with type 2 diabetes (T2DM). However, little known about platelets' disturbances among children 1 (T1DM). The aim the study was to investigate whether morphology or function are altered diabetes, potentially predisposing them future.The group consisted 389 T1DM during 2008-2010 period. Patients acute complications and ongoing infections were excluded from study. An equinumerous (N...
Gestational diabetes mellitus (GDM) is a disorder which manifests itself for the first time during pregnancy and mainly connected with glucose metabolism. It also known that fatty acid profile changes in erythrocyte membranes plasma could be associated obesity insulin resistance. These factors can lead to development of diabetes. In reported study, we applied untargeted analysis GDM against standard glucose-tolerant (NGT) women identify differences metabolomic profiles between those groups....
A key driver of Glioblastoma (GBM) heterogeneity and therapy resistance is the capacity glioma stem-like cells (GSCs) to hijack developmental signaling programs. However, it remains unclear how GSCs regulate these adapted pathways might be therapeutically exploited. The arginine methyltransferase, CARM1, has been shown play critical roles in maintaining stem cell pluripotency, preventing differentiation, recently was discovered upregulated Glioblastoma. To date, there little no understanding...
Purpose: Recent studies indirectly suggest a possible link between food allergy (FA) and asthma.Most of them have evaluated the occurrence FA in asthmatic children, especially first year life, using questionnaire-based or specific IgE (sIgE) assay.The aim this study was to evaluate prevalence clinical impact IgE-mediated school children with asthma double-blind placebo-controlled challenge (DBPCFC).Methods: The group consisted atopic who were admitted Department Pediatric Allergology,...
Oncologists now favor more personalized treatment strategies in breast cancer patients. Gene expression analysis has been widely used, but less is known about epigenetic factors, for example, microRNAs (miRNAs). The aim of this study was to determine the relationship between selected miRNAs and receptor status core biopsies sampled before preoperative chemotherapy stage III locally advanced (LABC) In 37 LABC biopsies, three per sample were analyzed: hsa-miR-93-5p, hsa-miR-190a,...
Reduced expression of TP53 by promoter methylation has been reported in several neoplasms. It remains unclear whether is associated with reduced transcriptional and protein glioblastoma (GB). The aim our work was to study the impact mutations on mRNA level 42 molecularly characterized primary GB tumors. We also evaluate all molecular alterations overall patient survival. frequency found 21.4%. To best knowledge, this first report showing such high GB. There no relation between (p=0.5722)...
Abstract Burn induces a systemic response affecting multiple organs, including the liver. Since liver plays critical role in metabolic, inflammatory, and immune events, patient with impaired often exhibits poor outcomes. The mortality rate after burns elderly population is higher than any other age group, studies show that of aged animals more susceptible to injury burns. Understanding aged-specific fundamental improving health care. Furthermore, no liver-specific therapy exists treat...
Background Estimated monogenic diabetes (MD) prevalence increases as screening programs proceeds. Objective To estimate of MD among Polish children. Subjects Patients and their family members suspected suffering from (defined causative mutation in one the Maturity Onset Diabetes Young or permanent neonatal mellitus genes) were recruited between January 2005 December 2015. Methods Nationwide was estimated based on data 6 administrative provinces (out 16 Poland) with high referral rates...
Abstract Background: The aim of the study was to compare selected markers in children with and without partial clinical remission (CR) newly diagnosed type 1 diabetes (T1D). Methods: group consisted 186 patients (F/M; 87/99) at onset T1D 24 months follow-up. Partial CR defined as insulin requirement <0.5 IU/kg glycated hemoglobin (HbA Results: observed 115/186 (61.83%) patients. At diagnosis body mass index standard deviation (BMI SDS) higher among remitters than non-remitters (p=0.0051)...