A5003302153- Cancer-related Molecular Pathways
- DNA Repair Mechanisms
- RNA modifications and cancer
- Glycosylation and Glycoproteins Research
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- Monoclonal and Polyclonal Antibodies Research
- Genomics and Chromatin Dynamics
- interferon and immune responses
- Heat shock proteins research
- BRCA gene mutations in cancer
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Cancer Mechanisms and Therapy
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- RNA and protein synthesis mechanisms
- CRISPR and Genetic Engineering
- Sirtuins and Resveratrol in Medicine
- Carcinogens and Genotoxicity Assessment
- Nutrition, Genetics, and Disease
- Immune cells in cancer
- Cell death mechanisms and regulation
The Maria Sklodowska-Curie National Research Institute of Oncology
2014-2025
University of Silesia in Katowice
2013
National Institutes of Health
2005
National Cancer Institute
2004
Jagiellonian University
2004
Centrum Onkologii
1992
Polymorphisms in DNA repair genes may be associated with differences the efficiency of damage and influence an individual's risk lung cancer. The frequencies several amino acid substitutions XRCC1 (Arg194Trp, Arg280His Arg399Gln), XRCC3 (Thr241Met), XPD (Ile199Met, His201Tyr, Asp312Asn Lys751Gln) XPF (Pro379Ser) were studied 96 non-small-cell cancer (NSCLC) cases healthy controls matched for age, gender cigarette smoking. codon 312 Asp/Asp genotype was found to have almost twice when Asp/Asn...
P1 is a bacteriophage of Escherichia coli and other enteric bacteria. It lysogenizes its hosts as circular, low-copy-number plasmid. We have determined the complete nucleotide sequences two strains thermoinducible mutant, c1-100. The genome (93,601 bp) contains at least 117 genes, which almost two-thirds had not been sequenced previously 49 no homologs in organisms. Protein-coding genes occupy 92% are organized 45 operons, four decisive for choice between lysis lysogeny. Four others ensure...
PPM1D (WIP1) negatively regulates by dephosphorylation many proteins including p53 tumour suppressor. The truncating mutations (nonsense and frameshift) in exon 6 of were found recently blood cells patients with breast, ovarian or colorectal cancer. These mutants code for gain-of-function retained phosphatase activity. Their significance carcinogenesis is unknown. was sequenced DNA 543 non-small-cell lung cancer (NSCLC). functional selected alterations (Arg458X, Lys469Glu) compared the...
Summary Functional genetic polymorphisms of DNA repair genes are good candidates for cancer susceptibility markers. We studied two coding proteins removing small adducts by direct (MGMT), or mispaired bases base excision (TDG). The non‐silent MGMT (84:Phe, 143:Val, 178:Arg) and TDG (199:Ser, 367:Met), the functional enhancer polymorphism, did not show any statistically significant association with lung risk in our case‐control analysis, but due to relatively number individuals, strong...
Abstract Heat shock can induce either cytoprotective mechanisms or cell death. We found that in certain human and mouse cells, including spermatocytes, activated heat factor 1 (HSF1) binds to sequences located the intron(s) of PMAIP1 (NOXA) gene upregulates its expression which induces apoptosis. Such a mode activation is not dependent on p53. Therefore, HSF1 only activate genes encoding proteins, prevents apoptosis, but it also positively regulate proapoptotic gene, facilitates This could...
A deficiency in DNA repair is associated with increased cancer risk. Inter-individual variations capacity observed humans may result from genetic polymorphisms genes. In order to provide a basis for future functional and molecular epidemiology studies on susceptibility, we screened 35 individuals coding regions of XPA XPB genes involved nucleotide excision (NER). Relevant cDNA sequences were amplified by PCR, sequenced fluorescently labeled terminators analyzed automated sequencer. Two...
p53 tumor suppressor is best known from controlling cell cycle, apoptosis, DNA repair, and metabolism, but it also regulates immunity able to impede the live cycle of viruses. For this reason these infectious agents encode proteins, which inactivate p53. However, what less that can be inactivated by human pathogenic bacteria. It probably not a collateral damage, specific targeting, because could interfere with their multiplication. The mechanisms antibacterial activity are poorly known. they...
The p15(INK4B), p16(INK4) and p18 genes are members of the gene family coding for inhibitors cyclin-dependent kinases 4 6. p15(INK4B) located at 9p21, a chromosomal region frequently deleted in many human neoplasms. To examine role these 3 lung carcinogenesis, somatic mutations within were analyzed by single-strand conformation polymorphism DNA sequencing 71 non-small-cell cancer (NSCLC) samples. Six cases with polymorphic allele observed. Loss heterozygosity was found 1 sample. We did not...
Polymorphisms in DNA repair genes may modulate not only an individual capacity, damage levels and cancer risk but also clinical outcome after damage-inducing anticancer therapy. In this study, we analyzed the association between XPA -4G>A, XPD Asp312Asn, hOGG1 Ser326Cys, XRCC1 Arg399Gln, XRCC2 -4234G>C, XRCC3 -4541A>G Thr241Met polymorphisms prognosis 250 inoperable non-small cell lung (NSCLC) patients treated with radiotherapy platinum-based chemotherapy. univariate model, XPA-4A 399Gln...
Abstract Due to immunosuppressive properties and confirmed tropism towards cancer cells mesenchymal stromal (MSC) have been used in many trials. In our study we these as carriers of IL-12 the treatment mice with primary metastatic B16-F10 melanomas. has anti-cancer activity, induces a strong immune response against acts an anti-angiogenic agent. A major limitation use therapy is its systemic toxicity. The aim work was develop system which cytokine may be administered intravenously without...