A5001346356- Global Cancer Incidence and Screening
- Economic and Financial Impacts of Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Screening and Detection
- Cancer Risks and Factors
- Multiple and Secondary Primary Cancers
- Healthcare Policy and Management
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Nutritional Studies and Diet
- Frailty in Older Adults
- Breast Cancer Treatment Studies
- Thyroid Cancer Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Chemokine receptors and signaling
- Chronic Lymphocytic Leukemia Research
- Radiation Dose and Imaging
- Lung Cancer Diagnosis and Treatment
- Carcinogens and Genotoxicity Assessment
- Cutaneous Melanoma Detection and Management
- Pancreatic and Hepatic Oncology Research
- Cytokine Signaling Pathways and Interactions
- Nutrition, Genetics, and Disease
- Esophageal Cancer Research and Treatment
National Cancer Institute
2016-2025
National Institutes of Health
2013-2024
Center for Cancer Research
2011-2022
Cancer Institute (WIA)
2011-2020
National Human Genome Research Institute
2018
RTI International
2018
United States Department of Health and Human Services
2014-2016
Johns Hopkins University
2011-2015
Walter Reed National Military Medical Center
2010-2014
Unifor
2013
Abstract Thyroid cancer incidence has been rising in the United States, and this trend often attributed to heightened medical surveillance use of improved diagnostics. varies by sex race/ethnicity, these factors also influence access utilization healthcare. We therefore examined thyroid rates demographic tumor characteristics based on 48,403 patients diagnosed during 1980–2005 from Surveillance, Epidemiology End Results program National Cancer Institute. The varied histologic type, sex,...
The prevalence of cancer survivorship is increasing. In this study, we provide contemporary population-based estimates and projections the overall site-specific cancer-attributable medical care costs in United States.We identified survivors aged ≥65 years diagnosed with between 2000 2012 from Surveillance, Epidemiology, End Results (SEER)-Medicare database used 2007 to 2013 claims estimate by site, phases care, stage at diagnosis. Annualized average for (Medicare Parts A B) oral prescription...
Previous studies that were based primarily on small numbers of patients suggested certain circulating proinflammatory cytokines may be associated with lung cancer; however, large independent are lacking. Associations between serum interleukin 6 (IL-6) and 8 (IL-8) levels cancer analyzed among 270 case 296 control subjects participating in the National Cancer Institute-Maryland (NCI-MD) case–control study. Results validated 532 595 a nested study within prospective Prostate, Lung, Colorectal,...
Polymorphisms in DNA repair genes may be associated with differences the efficiency of damage and influence an individual's risk lung cancer. The frequencies several amino acid substitutions XRCC1 (Arg194Trp, Arg280His Arg399Gln), XRCC3 (Thr241Met), XPD (Ile199Met, His201Tyr, Asp312Asn Lys751Gln) XPF (Pro379Ser) were studied 96 non-small-cell cancer (NSCLC) cases healthy controls matched for age, gender cigarette smoking. codon 312 Asp/Asp genotype was found to have almost twice when Asp/Asn...
Purpose There are no nationally representative data on oncologists’ use of next-generation sequencing (NGS) testing in practice. The purpose this study was to investigate how oncologists the United States NGS tests evaluate patients with cancer and inform treatment recommendations. Methods used from National Survey Precision Medicine Cancer Treatment, which mailed a sample 2017 (N = 1,281; cooperation rate 38%). Weighted percentages were calculated describe test use. Multivariable modeling...
Abstract Accumulating evidence suggests a role for inflammation in the development and progression of cancer. Our group recently identified cytokine gene signature lung tissue associated with cancer prognosis. Therefore, we hypothesized that concentrations circulating cytokines serum may be survival. Ten cytokines, namely, interleukin (IL)-1β, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, granulocyte macrophage colony-stimulating factor, interferon (IFN)-γ, tumor necrosis factor-α, were assessed 353...
Despite being the basis of one most effective interventions in lung cancer, little is known about patterns epidermal growth factor receptor (EGFR) mutation testing general population. We assessed frequencies and determinants EGFR erlotinib treatment among a population-based sample. A random sample (n = 1,358) patients diagnosed 2010 with histologically-confirmed NSCLC, as reported to Surveillance Epidemiology End Results (SEER) program, had their medical records abstracted treating...
Several studies have reported bidirectional inverse associations between cancer and Alzheimer's disease (AD). This study evaluates these relationships in a Medicare population. Using Surveillance, Epidemiology, End Results (SEER) linked to data, 1992-2005, we evaluated risks following AD case-control of 836,947 cases 142,869 controls as well risk after 742,809 patients non-cancer group 420,518. We applied unconditional logistic regression estimate odds ratios (ORs) Cox proportional hazards...
Abstract Studies have shown that Whites a higher colorectal cancer survival rate than Blacks. However, it is unclear whether racial disparities result from unequal access to medical care or factors other health both. This study assessed non-Hispanic (NHW) and Blacks (NHB) differ in colon an equal-access system examined differences varied by demographic tumor characteristics. The included 2,537 Military Health System patients diagnosed with between 1998 2007. Median follow-up time was 31.4...
The purpose of this study was to evaluate the potential collective opportunities and challenges transforming real-world data (RWD) evidence for clinical effectiveness by focusing on aligning analytic definitions oncology end points. Patients treated with a qualifying therapy advanced non-small cell lung cancer in frontline setting meeting broad eligibility criteria were included reflect population. Although trend toward improved outcomes patients receiving PD-(L)1 over standard chemotherapy...
Abstract Lung cancer is primarily caused by tobacco smoking, but susceptibility likely modified common genetic variation. In response to many forms of cellular stress, including DNA damage, the p53 protein functions induce cell cycle arrest, repair, senescence, or apoptosis. We hypothesized that TP53 haplotypes modulate pathways lung carcinogenesis and prognosis. To investigate our hypothesis, 14 polymorphisms in TP53, haplotype tagging coding single nucleotide polymorphisms, were genotyped...
Abstract Background: Racial disparities in lung cancer outcomes have been observed the general population. However, it is unclear whether survival differences persist when patients equal access to health care. Our objective was determine if differed among black and white U.S. Military Health System (MHS), an care system. Methods: The study subjects were 10,181 identified through Department of Defense's Automated Central Tumor Registry, who 20 years old or more diagnosed with between 1990...
Abstract Background: Increases in thyroid papillary carcinoma incidence rates have largely been attributed to heightened medical surveillance and improved diagnostics. We examined an equal-access health care system by demographics that are related incidence. Methods: Incidence during 1990–2004 among white black individuals aged 20 49 years the military, general U.S. population were compared using data from Department of Defense's Automated Central Tumor Registry National Cancer Institute's...
African Americans have a higher risk of developing lung cancer than European Americans. Previous studies suggested that certain circulating cytokines were associated with cancer. We hypothesized variations in serum cytokine levels exist between and Americans, increased contribute to differently the two races.Differences 10 levels, IL1β, IL4, IL5, IL6, IL8, IL10, IL12, granulocyte macrophage colony-stimulating factor, IFNγ, TNFα, 170 African-American 296 European-American controls from...
TAILORx demonstrated that women with node-negative, hormone receptor-positive, HER2-negative breast cancers and Oncotype DX recurrence scores (RS) of 0-25 had similar 9-year outcomes endocrine vs chemo-endocrine therapy; evidence for aged 50 years younger RS 16-25 was less clear. We estimated how expected changes in practice following the trial might affect US costs initial 12 months care (initial costs).
Background: Cancer registry-based “primary payer at diagnosis” (PPDx) data are commonly used to evaluate the effect of insurance on cancer care outcomes, yet little is known about how well they capture Medicaid or Medicare enrollment. Methods: We linked National Institute’s Surveillance, Epidemiology, and End Results registry monthly Centers for Services (CMS) enrollment records, state-year policy, managed selected adults aged 19–64 years diagnosed between 2007 2011. bivariate analyses...