A5107982052- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Cytomegalovirus and herpesvirus research
- Neurological Complications and Syndromes
- Renal Diseases and Glomerulopathies
- Polyomavirus and related diseases
- COVID-19 Clinical Research Studies
- Pregnancy and Medication Impact
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 and healthcare impacts
- Viral-associated cancers and disorders
- Parvovirus B19 Infection Studies
- Adenosine and Purinergic Signaling
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Herpesvirus Infections and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Potassium and Related Disorders
- Educational and Psychological Assessments
- Dialysis and Renal Disease Management
- Oral and gingival health research
- Long-Term Effects of COVID-19
- Organ and Tissue Transplantation Research
- Psychology and Mental Health
Hospital Geral de Bonsucesso
2004-2018
Universidade de São Paulo
2015
Ministério da Saúde
2004
Background1-year data from this trial showed the noninferiority of a novel once-daily extended-release tacrolimus (LCPT; Envarsus XR) to immediate-release (IR-Tac) twice daily after kidney transplantation.Study DesignFinal 24-month analysis 2-armed, parallel-group, randomized, double-blind, double-dummy, multicenter, phase 3 trial.Setting & Participants543 de novo recipients randomly assigned LCPT (n = 268) or IR-Tac 275); 507 (93.4%) completed study.InterventionLCPT tablets once at 0.17...
Planned conversion from tacrolimus to sirolimus was evaluated in de novo kidney transplant recipients. In this multicenter, randomized, open-label study, 297 patients were initially treated with tacrolimus, mycophenolate sodium and prednisone. Of the 283 reaching 3 months, 97 converted (SRL), 107 maintained on (TAC) 79 receiving TAC without criteria undergo intervention at month (TACex). The primary objective show superior estimated glomerular filtration rate (eGFR) SRL group 24. 258 who...
The phase III Belatacept Evaluation of Nephroprotection and Efficacy as First-Line Immunosuppression Trial-Extended Criteria Donors Trial (BENEFIT-EXT) study compared more or less intensive belatacept-based immunosuppression with cyclosporine (CsA)-based in recipients extended criteria donor kidneys. In this post hoc analysis, patient outcomes were assessed according to kidney subtype. total, 68.9% patients received an expanded (United Network for Organ Sharing definition), 10.1% a donation...
This analysis, using data from the Brazilian kidney transplant (KT) COVID-19 study, seeks to develop a prediction score assist in risk stratification KT recipients. In this 1379 patients (35 sites) were enrolled, and machine learning approach was used fit models derivation cohort. A reduced Elastic Net model selected, accuracy predict 28-day fatality after diagnosis, assessed by area under ROC curve (AUC-ROC), confirmed validation The better calibration values build applicable ImAgeS score....
Background. The discard of expanded criteria donor (ECD) kidneys is unacceptably high, considering the growing demand for transplantation. Using machine perfusion may reduce rate, increase number transplants, and mortality on waiting list. Methods. We developed a 5-y Markov model to simulate incorporating pulsatile into current government-funded healthcare system. compared universal use static cold storage all with selective ECD kidneys. Real-life data were used compose cohort...
Abstract The increased risk for opportunistic infections after a renal transplant requires monitoring of viral to avoid future complications. Our goal was investigate the impact and factors associated with Epstein‐Barr virus (EBV), human cytomegalovirus (HCMV) herpesvirus type 6 (HHV‐6) viremia in recipients. Whole blood samples were collected monthly from 82 patients during first semester then quarterly up 1 year transplantation. EBV, HCMV, HHV‐6 detected quantified by TaqMan real‐time...
Medina-Pestana, J. O.; Garcia, V. D.; David-Neto, E.; Carvalho, D. D.B.M.; Contieri, F. L.; Abbud-Filho, M.; Silva, Tedesco H.; Ikehara, E. Author Information
Após mais de cem anos da descrição doença Whipple por George H. Whipple, o diagnóstico, patogênese e tratamento ainda permanecem motivo controvérsia. É decorrente rara infecção pela bactéria Tropheryma whipplei, que também é encontrada no meio ambiente sem causar dano. Os sintomas são inespecíficos, tais como: diarréia, artralgia inapetência, podendo apresentar graves cardíacos sistema nervoso central. O diagnóstico sensível realizado através PCR (reação em cadeia polimerase)...
Resumo Introdução: O micofenolato mofetil (MMF), pró-droga do ácido micofenólico (MPA), é um tratamento imunossupressor eficaz na profilaxia da rejeição aguda, mas associado a eventos adversos gastrointestinais. sódico (MPS) com revestimento entérico foi desenvolvido intenção de reduzir tais associados ao MPA. Objetivo: Avaliar tolerabilidade EC-MPS e MMF em receptores transplante renal. Métodos: Estudo retrospectivo, multicêntrico, pacientes submetidos renal entre 07/01/2004 31/07/2007 18...
Introduction: This multicenter prospective study evaluates renal function of kidney transplant recipients who underwent planned conversion from TAC to SRL-based regimen 3 months after transplantation. Methods: Low risk first receiving TAC, mycophenolate sodium (MPS) and prednisone showing good function, no proteinuria previous severe acute rejection at were randomized the surgery be converted SRL. The primary outcome is calculated glomerular filtration rate (cGFR, Cockroft-Gault) 24 using...
Data from the general population suggest that fatality rates declined during course of pandemic. This analysis, using data extracted Brazilian Kidney Transplant COVID-19 Registry, seeks to determine over time since index case on March 3rd, 2020. hospitalized patients with RT-PCR positive SARS-CoV-2 infection August 2020 (35 sites, 878 patients) were compared trend tests according quartiles (Q1: <72 days; Q2: 72-104 Q3: 105-140 Q4: >140 days after case). The 28-day decreased 29.5% (Q1) 18.8%...
The aim of this study was to characterize Brazilian-specific immunosuppressant (IS) treatment patterns among kidney transplant patients. Non-interventional, multicenter, medical chart review patients undergoing transplant. Five year follow-up data on IS medication use from adult (≥ 18 years old at time transplantation), single only transplants Jan/2004 Jan/2005 were collected 7 center in Brazilian hospitals. Patients censored graft loss or follow-up. Data 498 included; 51.2% female, the,...
Matuck, T; Miloski, F; Graciano, M; Morgado, L; Gouveia, Carvalho, D Author Information
Matuck, T; Carvalho, D; Gomes, P; Ribamar, E; Borela, A; Alvarenga, F Author Information
P1008 Objective: Evaluation of the effect chimeric Interleuleukin-2 receptor monoclonal antibody (Basiliximab - Simulect®) as induction therapy in high risk kidney transplant (Tx) recipients (R) on incidence and severity acute rejection (AR) episodes, graft loss, renal function, rate infection (I) deaths. Methods: 111 Tx performed between August/1999 May/2003 considered (cadaver donor, living donor PRA>30% recipient, children, reTx, prolonged cold ischemia time dialysis period time). The...
We investigated the effects of TNF-α, IFN-γ, IL-10 polymorphisms on viral infections (CMV, BKPyV, HHV-6, EBV) after renal transplantation. IFN-γ+874 A > T (lower IFN production) was associated with CMV disease (p = .039) in patients under mycophenolate-based therapy and graft failure .025). This study underscores role SNP infection.