A5082822383- Renal Diseases and Glomerulopathies
- Complement system in diseases
- Renal Transplantation Outcomes and Treatments
- Blood groups and transfusion
- Systemic Lupus Erythematosus Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pregnancy and preeclampsia studies
- Organ Transplantation Techniques and Outcomes
- Atherosclerosis and Cardiovascular Diseases
- SARS-CoV-2 and COVID-19 Research
- Dialysis and Renal Disease Management
- Drug-Induced Adverse Reactions
- T-cell and B-cell Immunology
- Trauma and Emergency Care Studies
- Iron Metabolism and Disorders
- Immune Cell Function and Interaction
- Health, Environment, Cognitive Aging
- Heparin-Induced Thrombocytopenia and Thrombosis
- Immunodeficiency and Autoimmune Disorders
Hospital Geral de Bonsucesso
2017-2025
Instituto de Urologia e Nefrologia
2024
American Society of Nephrology
2024
Atypical hemolytic uremic syndrome (aHUS) is a rare cause of thrombotic microangiopathy (TMA) caused by the dysregulation alternative complement pathway. The diagnosis TMA made clinically triad: microangiopathic anemia, thrombocytopenia, and organ damage (mainly acute kidney injury). heterogeneity clinical manifestation lack gold standard diagnostic test makes precise aHUS challenging process that may impact patient management. Until one decade ago, there was no specific treatment for...
<h2>Abstract</h2> The haemolytic uraemic syndromes (HUS) are a heterogeneous group of conditions only some which mediated by complement (CaHUS). We report the outcome 2023 International Society Nephrology HUS Forum where global panel experts considered current state art, identified areas uncertainty, and proposed optimal solutions. Areas uncertainty for future research included: nomenclature HUS; novel testing strategies; identification biomarkers; genetic predisposition to aHUS; dosing...
Systemic lupus erythematosus (SLE) is a severe autoimmune disease that involves multiple organ systems. Lupus nephritis (LN) complication of SLE and associated with poor survival high morbidity. Many genomic studies have been performed worldwide, several histocompatibility leukocyte antigen (HLA) loci are linked to susceptibility.The present study evaluated the association HLA alleles in patient population, LN group control group. The second objective whether allele match or mismatch...
Atypical hemolytic uremic syndrome (aHUS) is characterized by microangiopathic anemia, thrombocytopenia and kidney injury caused a dysregulation of the alternative complement pathway.We conducted multicenter nonregistry study aimed at collecting clinical, laboratory genetic information patients with aHUS in Brazil. Demographic data, findings, treatments outcomes are presented.Thirty-four were included, 62% female 67% Caucasian. Half had first manifestation before age 18 years (pediatric...
Large-scale COVID-19 vaccination has been one of the most effective strategies to control spread SARS-CoV-2 virus. However, several cases glomerular injury related vaccine have described in literature. We report two a tip lesion variant focal segmental glomerulosclerosis (FSGS), which presented with significant proteinuria and improved after immunosuppression. In our literature review, FSGS is currently frequent associated against COVID-19. Prognosis favorable without alterations...
A 17-year-old male presented thrombotic microangiopathy (TMA) at 6 months of age with arterial hypertension, anemia, thrombocytopenia and kidney injury improving plasma infusions. Fourteen years later, he was diagnosed severe increase in serum creatinine chronic TMA on biopsy. Eculizumab started after 18 treatment, persisted decline renal function proteinuria. Genetic analysis demonstrated mutation diacylglycerol kinase epsilon (DGKe). Complement blockade stopped. This case late diagnosis...
Chronic Kidney Disease (CKD) poses a significant global public health burden, impacting an estimated 800 million individuals worldwide. The increasing prevalence of non-communicable chronic diseases, including diabetes mellitus, hypertension, and obesity, further complicates this problem. In response to escalating challenge, the Nephrology Society Rio de Janeiro initiated targeted screening initiative aligned with World Day 2023, under theme 'Caring for Vulnerable Preparing Unforeseen Circumstances
Lupus nephritis (LN) is a prevalent and severe systemic lupus erythematosus (SLE) complication, affects 40-70% of patients, leading to increased morbidity mortality. Identifying prognostic markers understanding treatment response are critical. The objective this study was evaluate the immunosuppressive in LN assess proteinuria, complement levels C3 C4 at third, sixth, twelfth months therapy, correlate these findings.
Rose, S.; Holanda, M.; Pizanis, A.; Dike, J.; Bauer, Ziegenfu, T.ß; Marzi, I.; Bühren, V. Author Information