A5064824788- Polyomavirus and related diseases
- Full-Duplex Wireless Communications
- Plant Virus Research Studies
- Viral-associated cancers and disorders
- Antenna Design and Analysis
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Cervical Cancer and HPV Research
- Fungal and yeast genetics research
- Bacteriophages and microbial interactions
- Plant Reproductive Biology
- Mosquito-borne diseases and control
- Herpesvirus Infections and Treatments
- Animal Genetics and Reproduction
- SARS-CoV-2 and COVID-19 Research
- Virology and Viral Diseases
- RNA and protein synthesis mechanisms
- Parvovirus B19 Infection Studies
- Cytomegalovirus and herpesvirus research
- HIV/AIDS oral health manifestations
- Genomics and Chromatin Dynamics
- Organ Donation and Transplantation
- Pediatric Urology and Nephrology Studies
- Viral Infections and Vectors
Universidade Federal Fluminense
2013-2024
Weizmann Institute of Science
2019-2020
Universidade Federal do Rio de Janeiro
2016-2019
Hospital Universitário Clementino Fraga Filho
2018-2019
Background: Merkel cell polyomavirus (MCPyV) has been established as an etiological agent in carcinoma (MCC), yet its role other cutaneous neoplasms re-mains under investigation. In the context of non-melanoma skin cancer (NMSC), influence host immunogenetics on MCPyV persistence is poorly understood. Objec-tive: To investigate presence various lesions, particularly NMSC, and association with cytokine gene polymorphisms related to immune regulation. Methods: We analyzed 274 biopsies...
The localization of mRNAs encoding secreted/membrane proteins (mSMPs) to the endoplasmic reticulum (ER) likely facilitates co-translational translocation secreted proteins. However, studies have shown that mSMP recruitment ER in eukaryotes can occur a manner is independent ribosome, translational control, and signal recognition particle, although mechanism remains largely unknown. Here, we identify cis-acting RNA sequence motif enhances appears increase mRNA stability, both synthesis...
Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine cancer, with approximately 80% of cases associated polyomavirus (MCPyV). The lack information concerning its occurrence in non-MCC immunosuppressed populations led to the investigation MCPyV DNA saliva and oral biopsies from 60 kidney allograft recipients 75 non-transplanted individuals (control group). In contrast herpesviruses, which was also investigated (CMV, HHV-6A, B, HHV-7) detected predominantly patients lesions...
Merkel cell polyomavirus (MCPyV), a newly described oncogenic virus, has been found in association with tumours other than carcinoma (MCC). As yet, little is known about the involvement or influence of MCPyV on development these and its prevalence various populations.To assess DNA cases nonmelanoma skin cancer (NMSC).The was assessed 96 NMSC Brazilian population comprising 76 subjects, results were correlated epidemiological demographical data.MCPyV detected 23 69 (33.3%) basal carcinomas, 2...
SUMMARY The aim of this study was to investigate the association EBV and HPV with gingivitis and/or periodontitis according immunologic status. To end, 74 oral biopsies from transplanted non-transplanted individuals abovementioned manifestations were submitted a screening by PCR for both viruses. According results, strongly associated in (p = 0.011) but not 0.766). EBV-HPV co-detections did enhance presence tissue injury as well. Although causal relationship investigated study, higher...
Zika virus (ZIKV) is an emergent arbovirus that has attracted attention in the last year as a possible causative agent of congenital malformation; it shows remarkably increased microcephaly risk during otherwise healthy pregnancies. We present here analysis all ZIKV sequences available Genbank up to April 2016, studying mutations whole polyprotein and their structural implications for proteins E, NS1, NS3 NS5. This study suggests not consequence any particular amino acid substitution but,...
Abstract The increased risk for opportunistic infections after a renal transplant requires monitoring of viral to avoid future complications. Our goal was investigate the impact and factors associated with Epstein‐Barr virus (EBV), human cytomegalovirus (HCMV) herpesvirus type 6 (HHV‐6) viremia in recipients. Whole blood samples were collected monthly from 82 patients during first semester then quarterly up 1 year transplantation. EBV, HCMV, HHV‐6 detected quantified by TaqMan real‐time...
Abstract cis -acting RNA motifs play a major role in regulating many aspects of biology including posttranscriptional processing, nuclear export, localization, translation and degradation. Here we analyzed the genomes SARS-CoV-2 other single-strand (ssRNA) viruses for presence unique element called SECReTE. This motif consists 10 or more consecutive triplet nucleotide repeats where pyrimidine (C U) present every third base, which identified mRNAs encoding secreted proteins bacteria, yeast,...
This study aimed to investigate the presence of murine astrovirus (MuAstV) in Brazil. Fecal samples from mice belonging four Brazilian animal facilities were collected and tested for MuAstV using real-time polymerase chain reaction. Of 162 tested, 38 (23.5%) positive MuAstV, 33 (91.7%) which came specific-pathogen free colonies. Although most obtained asymptomatic animals, three presented diarrheal symptoms, was only agent detected by molecular assay. Phylogenetic analysis revealed...
BKV and JCV belong to the Polyomaviridae family are opportunistic agents associated with complications in immunocompromised individuals. Although a single screening assay for both viruses would be convenient, diversity of serotypes genotypes is methodological challenge. In this paper, we developed PCR method able detect segregate JCV, despite these genetic discrepancies. A duplex semi-nested (duplex snPCR) was designed target conserved region (639nt-1516nt) within VP2 gene. first PCR, primer...
Merkel cell polyomavirus (MCPyV) large T antigen (LT-ag) is frequently found truncated in carcinomas (MCC) and it considered a major tumor-specific signature. Nonetheless, the biological role of LT-ag nontruncated mutations largely unknown. In this study, MCPyV second exon from 11 non-MCC oral samples NCBI sequences derived different anatomical sites were studied genetic structural standpoint. As expected, mutation profile was influenced by geographical origin sample, although nonsynonymous...
Abstract The yeast mating pathway regulates haploid cell fusion in response to pheromone signaling via a mitogen-activated protein kinase (MAPK) cascade that controls directional growth (chemotropism). However, the regulators of chemotropic morphogenesis are ill-defined. By using non-biased genome-wide screen, we identified hundreds genes affect mating. An additional screens and validated >20 novel positive negative gradient sensing, chemotropism, shmoo development, Aside from known...
Introduction: The genital infection by the human papillomavirus (HPV) can result in a sexually transmitted disease associated with precursor lesions for carcinogenesis tract. In recent years, evidence was accumulated defining HPV as etiologic agent of cervical cancer; however, etiology penile cancer is still open and lacks studies. This study aims to contribute epidemiologic knowledge regarding prevalence this virus malignant male tract, using DNA microarray assay, technique that allows...