Background While significant advances have been made in uncovering the aetiology of Alzheimer's disease and related dementias at genetic level, molecular events epigenetic level remain largely undefined. Emerging evidence indicates that small non-coding RNAs (sncRNAs) their associated RNA modifications are important regulators complex physiological pathological processes, including aging, stress responses, inheritance. However, whether altered dementia is not known. Methods We performed...

Background: Merkel cell polyomavirus (MCPyV) has been established as an etiological agent in carcinoma (MCC), yet its role other cutaneous neoplasms re-mains under investigation. In the context of non-melanoma skin cancer (NMSC), influence host immunogenetics on MCPyV persistence is poorly understood. Objec-tive: To investigate presence various lesions, particularly NMSC, and association with cytokine gene polymorphisms related to immune regulation. Methods: We analyzed 274 biopsies...

O angiomioma agressivo é um tumor mesenquimal raro, de crescimento lento e comportamento localmente invasivo, com maior prevalência em mulheres na região pélvica perineal, mas também relatado homens. Caracteriza-se histologicamente por uma matriz mixoide rica vasos e, clinicamente, pela tendência à recidiva local, mesmo após excisão cirúrgica completa. Diagnósticos diferenciais incluem lipossarcoma outros tumores tecidos moles, sendo o diagnóstico frequentemente confirmado exames imagem,...

To investigate the criterion-related validity, test-retest and inter-rater reliabilities of modified sphygmomanometer test (MST) for assessment strength trunk lower limb muscles in subjects with chronic stroke, to verify whether number trials affected results.Fifty-nine stroke (mean age 57.80 years; standard deviation 13.79 years) were included study. Maximum isometric was assessed a hand-held dynamometer MST. results, one-way analysis variance applied. For MST, Pearson correlation...

BACKGROUND : Tests that are usually employed for the clinical assessment of muscular strength have notable disadvantages. The Modified Sphygmomanometer Test (MST) is a promising method because it low-cost and provides objective measures. OBJECTIVES To investigate most adequate sources outcome values with MST. METHOD Methodological study 40 healthy adults (22.98±2.26 years), who did not practice physical activity regularly. flexors extensors elbow knee, handgrip dominant side anterior trunk...

Activation of the brain renin-angiotensin system (RAS) is a pivotal step in pathogenesis hypertension. The paraventricular nucleus (PVN) hypothalamus critical part angiotensinergic sympatho-excitatory neuronal network involved neural control blood pressure and However, importance PVN (pro)renin receptor (PVN-PRR)-a key component RAS-in hypertension development has not been examined. In this study, we investigated involvement mechanisms PVN-PRR DOCA-salt-induced hypertension, mouse model...

INTRODUÇÃO: O Teste do esfigmomanômetro modificado (TEM) tem potencial de ampla aplicação clínica para mensuração da força muscular. OBJETIVO: Realizar uma revisão literatura descrever como o TEM vem sendo utilizado avaliação muscular, bem suas propriedades medida. MATERIAIS E MÉTODOS: Foram realizadas buscas nas bases dados MEDLINE/LILACS/SciELO/PEDro com combinação termos específicos, sem restrições quanto ao idioma e publicados até novembro/2011, seguida busca manual ativa. Todos os...

Overstimulation of the renin-angiotensin system (RAS) has been implicated in pathogenesis various cardiovascular diseases. Alamandine is a peptide newly identified as protective component RAS; however, mechanisms involved its beneficial effects remain elusive. By using well-characterized rat model hypertension, TGR (mREN2)27, we show that mREN ventricular myocytes are prone to contractile enhancement mediated by short-term alamandine (100 nmol/L) stimulation Mas-related G protein-coupled...

To investigate the reliability (test-retest and inter-rater) criterion-related validity of modified sphygmomanometer test (MST) for assessment upper limb muscle strength in subjects with chronic stroke, to determine whether results are affected by number trials.The 11 groups 57 stroke was bilaterally assessed portable dynamometers MST (measured mmHg). trials would affect results, 1-way analysis variance applied. For test-retest/inter-rater reliabilities MST, intra-class correlation...

We report here that the neuronal (pro)renin receptor (PRR), a key component of brain renin-angiotensin system (RAS), plays critical role in central regulation high-fat-diet (HFD)-induced metabolic pathophysiology. The PRR is known to mediate formation majority angiotensin (ANG) II, bioactive peptide RAS, nervous and regulate blood pressure cardiovascular function. However, little about function overnutrition-related physiology. Here, we show deletion neurons reduces pressure, neurogenic...

High salt (sodium) intake leads to the development of hypertension despite fact that plasma sodium concentration ([Na+]) is usually normal in hypertensive human patients. Increased cerebrospinal fluid (CSF) contributes elevated sympathetic activity and high blood pressure (BP) rodent models hypertension. However, whether there an increased accumulation CSF humans with chronic not well defined. Here, we investigated [Na+] from normotensive subjects family histories Alzheimer's disease samples...

Overactivation of the renin-angiotensin system (RAS)—a central physiological pathway involved in controlling blood pressure (BP)—leads to hypertension. It is now well recognized that nervous (CNS) has its own local RAS, and majority components are known be expressed brain. In pathological states, (pro)renin receptor (PRR), a novel component brain plays key role formation angiotensin II (Ang II) also mediates Ang II-independent PRR signaling. A recent study reported neuronal activation...

Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of damage directly related to diabetes, obesity, and metabolic syndrome. The (pro)renin receptor (PRR) has recently been demonstrated play role in glucose lipid metabolism. Here, we test the hypothesis that PRR regulates development diet-induced hepatic steatosis fibrosis. C57Bl/6J mice were fed high-fat diet (HFD) or normal-fat (NFD) with matching calories for 6 weeks. An 8-week methionine choline-deficient (MCD) was used induce...

Glucose homeostasis is achieved via complex interactions between the endocrine pancreas and other peripheral tissues glucoregulatory neurocircuits in brain that remain incompletely defined. Within brain, neurons hypothalamus appear to play a particularly important role. Consistent with this notion, we report evidence (pro)renin receptor (PRR) signaling within subset of tyrosine hydroxylase (TH) located hypothalamic paraventricular nucleus (PVNTH neurons) physiological determinant defended...

A crescente evolução de práticas mercado alinhada a princípios socioambientais, tem surtido em esfera global um efeito positivo e influenciado cada vez mais novo modelo negócios ações. O presente trabalho destaca analisa as principais no que tange Environmental, Social and Governance (ESG) são pilares ambientais, sociais governança empresas pequeno porte seus desafios para corrente sustentável desenvolvimento políticas estaduais, nas cidades Rolim Moura Alta floresta d’ Oeste/RO. Aplica-se...

The administration of cyclophosphamide (50 to 100 mg/kg) at 48 72 h before removal murine lung or spleen mononuclear cells for culture rendered DBA/2 mice incapable generating an effective cytotoxic T-lymphocyte response influenza A virus-infected cells. precursor frequency virus in and from cyclophosphamide-treated was significantly decreased when compared with that normal littermate controls. low activity the lungs spleens could be partially restored vitro by human interleukin 2.

This paper deals with a methodology for the assessment of power quality indices in electric distribution system, particularly related to voltage harmonic distortions. The also presents proposal measurement protocol, testing procedure evaluate existing meters and recommendations introduction consistent parameters support implementation standards systems.

Chlorisondamine (CSD) has been used to assess the neurogenic contribution blood pressure (BP) and vasomotor sympathetic tone in animal models. It is assumed that reduction BP following CSD administration associated decreases cardiac output (CO) peripheral resistance, reflecting tone, respectively. Surprisingly, this not characterized experimentally mice, despite extensive use of model cardiovascular research. We hypothesize a specific dose can selectively block tone. To test hypothesis, we...