A5060579187- Polyomavirus and related diseases
- Full-Duplex Wireless Communications
- Herpesvirus Infections and Treatments
- Viral gastroenteritis research and epidemiology
- Plant Virus Research Studies
- Mosquito-borne diseases and control
- Respiratory viral infections research
- Viral Infections and Vectors
- Cytomegalovirus and herpesvirus research
- Antenna Design and Analysis
- Vector-borne infectious diseases
- COVID-19 Clinical Research Studies
- Parvovirus B19 Infection Studies
- SARS-CoV-2 and COVID-19 Research
- Virus-based gene therapy research
- Viral-associated cancers and disorders
- Microwave Engineering and Waveguides
- Research on Leishmaniasis Studies
- Antimicrobial Resistance in Staphylococcus
- Bacterial biofilms and quorum sensing
- SARS-CoV-2 detection and testing
- Viral Infections and Immunology Research
- Tracheal and airway disorders
- Autoimmune Neurological Disorders and Treatments
- Peripheral Neuropathies and Disorders
Universidade Federal do Rio de Janeiro
2013-2024
Hospital Universitário Clementino Fraga Filho
1997-2023
Universidade Federal Fluminense
2022
University of Rio Grande and Rio Grande Community College
2005
Instituto Português de Oncologia Francisco Gentil
2003
Czech Academy of Sciences, Institute of Microbiology
2001
Fundação Oswaldo Cruz
1997
During 1985-1995, illnesses clinically and epidemiologically compatible with Brazilian spotted fever were identified in 17 patients the county of Pedreira, state São Paulo, Brazil. Spotted-fever group rickettsial infection was confirmed by serology and/or immunostaining tissues 10 these patients. Immunostaining a 37-year-old pregnant patient, although antigens not demonstrable fetus. A serosurvey conducted four localities to determine prevalence subclinical or asymptomatic infections...
The SARS-CoV-2 responsible for the ongoing COVID pandemic reveals particular evolutionary dynamics and an extensive polymorphism, mainly in Spike gene. Monitoring S gene mutations is crucial successful controlling measures detecting variants that can evade vaccine immunity. Even after costs reduction resulting from pandemic, new generation sequencing methodologies remain unavailable to a large number of scientific groups. Therefore, support urgent surveillance gene, this work describes...
Background: Merkel cell polyomavirus (MCPyV) has been established as an etiological agent in carcinoma (MCC), yet its role other cutaneous neoplasms re-mains under investigation. In the context of non-melanoma skin cancer (NMSC), influence host immunogenetics on MCPyV persistence is poorly understood. Objec-tive: To investigate presence various lesions, particularly NMSC, and association with cytokine gene polymorphisms related to immune regulation. Methods: We analyzed 274 biopsies...
This paper reports the first isolation of a spotted fever group rickettsia from an Amblyomma cooperi ixodid collected capybara (Hydrochaeris hydrochaeris) in endemic area County Pedreira, State São Paulo, Brazil. Isolation was performed Vero cell culture and submitted to immunofluorescence, using antibody Rickettsia rickettsii-positive human serum.
Ticks were collected from vegetation and animals at monthly intervals during one year (1993-1994) in an endemic area of Brazilian spotted fever the County Pedreira, State São Paulo. Six species ticks identified Amblyomma cajennense, cooperi, triste, Anocentor nitens, Rhipicephalus sanguineus Boophilus microplus. Only first was sufficiently numerous to permit a quantitative study with seasonal activity, although distribution source capture other observed are reported. This information is...
ABSTRACT The prevalence of mutations that confer resistance to antiretroviral drugs was examined in 56 drug-naive, human immunodeficiency virus type 1 (HIV-1)-infected individuals from the Army Health Service Rio de Janeiro, Brazil. No primary protease inhibitor were found, but secondary observed 51.2% samples. Fourteen percent viruses had reverse transcriptase inhibitor-associated mutations. Comparative analysis four different time periods drug-naive patients city Janeiro has indicated...
Human bocavirus (HBoV) is an emerging virus and has been detected worldwide, especially in pediatric patients with respiratory gastrointestinal infection. In this study, we describe HBoV prevalence, genotypes circulation DNA shedding, stool samples from children up to two years of age Brazil. During 2016 2017, 886 acute gastroenteritis (AGE) ten Brazilian states were analyzed by TaqMan®-based qPCR, detect quantify HBoV. Positive genotyped sequencing the VP1/2 overlap region, followed...
Abstract Norovirus is a major cause of acute diarrheal disease (ADD) outbreaks worldwide. In the present study, we investigated an ADD outbreak caused by norovirus in several municipalities Santa Catarina state during summer season, southern Brazil 2023. As 10th epidemiological week 2023, approximately 87 000 cases were reported, with capital, Florianópolis, recording highest number throughout weeks. By using RT‐qPCR and sequencing, detected 10 different genotypes, from both genogroups (G) I...
In order to obtain information on Brazilian spotted fever, a study in domestic animals was performed the County of Pedreira, State São Paulo, Brazil, where 17 human cases had been notified. Serum samples obtained from were tested by indirect immunofluorescence for detectable antibodies fever-group rickettsiae. Seropositivity revealed 12 (36.4%) 33 dogs and seven (77.8%) nine horses endemic area. For comparison, blood non area four (12.9%) 31 three (27.3%) 11 positive. The highest titers IFA...
Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine cancer, with approximately 80% of cases associated polyomavirus (MCPyV). The lack information concerning its occurrence in non-MCC immunosuppressed populations led to the investigation MCPyV DNA saliva and oral biopsies from 60 kidney allograft recipients 75 non-transplanted individuals (control group). In contrast herpesviruses, which was also investigated (CMV, HHV-6A, B, HHV-7) detected predominantly patients lesions...
Merkel cell polyomavirus (MCPyV), a newly described oncogenic virus, has been found in association with tumours other than carcinoma (MCC). As yet, little is known about the involvement or influence of MCPyV on development these and its prevalence various populations.To assess DNA cases nonmelanoma skin cancer (NMSC).The was assessed 96 NMSC Brazilian population comprising 76 subjects, results were correlated epidemiological demographical data.MCPyV detected 23 69 (33.3%) basal carcinomas, 2...
SUMMARY The aim of this study was to investigate the association EBV and HPV with gingivitis and/or periodontitis according immunologic status. To end, 74 oral biopsies from transplanted non-transplanted individuals abovementioned manifestations were submitted a screening by PCR for both viruses. According results, strongly associated in (p = 0.011) but not 0.766). EBV-HPV co-detections did enhance presence tissue injury as well. Although causal relationship investigated study, higher...
Introduction The coronavirus disease-2019 (COVID-19) clinical manifestations in children and adolescents are diverse, despite the respiratory condition being main presentation. Factors such as comorbidities other infections may play a role initial presentation of severe acute syndrome 2 (SARS-CoV-2) infection. This study aims to describe epidemiological aspects, clinical, laboratory pediatric patients admitted tertiary hospital Rio de Janeiro, diagnosed with COVID-19, compare these viral...
Merkel cell polyomavirus (MCPyV) is an oncogenic virus etiologically related to carcinoma and has been found in association with non-melanoma skin cancer (NMSC), controversial results. Little known about the role or influence of MCPyV development these tumors its prevalence various populations. To assess MCPyV`s Large T Antigen DNA cases NMSC, nested-PCR immunohistochemistry (IHC) were performed on 103 samples NMSC from 91 patients results correlated epidemiological demographical data. A...
Molecular detection of Merkel cell polyomavirus in basal carcinoma and perilesional
Neurological manifestations of COVID-19 may affect both central and peripheral nervous systems. Unlike in adults, whom majority severe cases derive from respiratory complications, neurological involvement is one the main causes children. This study aimed to detect viral pathogens, mainly SARS-CoV-2, nasopharynx cerebrospinal fluid samples utilizing qRT-PCR (TaqMan) a pediatric population Brazil. We evaluated four children with symptoms laboratory-confirmed SARS-CoV-2 infection: three...
The reactivation of Herpes Simplex virus (HSV) occurs in 70% to 80% patients submitted autologous stem cell transplantation (ASCT); it increases the severity chemotherapy-induced mucositis. Therefore, use acyclovir ASCT is considered standard practice. However, minimum dose needed prevent a matter debate. We compared two doses non-randomized fashion 59 ASCT: 32 received 125 mg/m² IV every six hours and subsequent 27 60 hours. Viral excretion was evaluated through weekly viral culture oral...