A5031433657- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- COVID-19 Clinical Research Studies
- Organ Transplantation Techniques and Outcomes
- Long-Term Effects of COVID-19
- Dialysis and Renal Disease Management
- COVID-19 and healthcare impacts
- Renal and Vascular Pathologies
- Blood Pressure and Hypertension Studies
- Autoimmune and Inflammatory Disorders Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Liver Disease and Transplantation
- Maternal and Neonatal Healthcare
- SARS-CoV-2 and COVID-19 Research
- Cytomegalovirus and herpesvirus research
- Neurological Complications and Syndromes
- Transplantation: Methods and Outcomes
- Adolescent and Pediatric Healthcare
- Tuberculosis Research and Epidemiology
- Liver Disease Diagnosis and Treatment
- Viral Infections and Vectors
- Malaria Research and Control
- Renal Diseases and Glomerulopathies
- Mosquito-borne diseases and control
- Immunodeficiency and Autoimmune Disorders
Hospital Geral de Fortaleza
2015-2024
National Water Agency
2015
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2015
Universidade Federal do Ceará
2015
Brazilian Medical Association
2014
Background Kidney transplant (KT) recipients are considered a high-risk group for unfavorable outcomes in the course of coronavirus disease 2019 (COVID-19). Aim To describe clinical aspects and COVID-19 among KT recipients. Methods This multicenter cohort study enrolled 1,680 diagnosed with between March November 2020, from 35 Brazilian centers. The main outcome was 90-day cumulative incidence death, entire according to acute kidney injury (AKI) renal replacement therapy (RRT) requirement....
Background. Phase II trials of FTY720, a novel immunomodulator, have shown promise in preventing rejection with both standard and reduced cyclosporine exposure. This study was designed to confirm those findings. Methods. one-year, multicenter, randomized, phase III 696 de novo renal transplant patients compared FTY720 5 mg plus reduced-dose (RDC) or 2.5 full-dose (FDC) mycophenolate mofetil (MMF) FDC. All received concomitant corticosteroid therapy without antibody induction. The primary...
A hipertensão arterial sistêmica (HAS) tem, a longo prazo, impacto significativo no risco cardiovascular e na função do enxerto entre os transplantados renais. Além disso, existe uma relação causal em sentido de mão dupla renal HAS. Monitorização Ambulatorial da Pressão Arterial (MAPA), por sua melhor correlação com desfechos renais cardiovasculares, é considerada o padrão-ouro determinação diagnóstico doença hipertensiva. Diante este artigo propõe descrever sugestão protocolo assistencial...
This study evaluated the risk factors for delayed graft function (DGF) in a country where its incidence is high, detailing donor maintenance-related (DMR) variables and using machine learning (ML) methods beyond traditional regression-based models.A total of 443 brain dead deceased kidney transplants (KT) from two Brazilian centers were retrospectively analyzed following DMR predictive modeling: arterial blood gas pH, serum sodium, glucose, urine output, mean pressure, vasopressors use,...
This analysis, using data from the Brazilian kidney transplant (KT) COVID-19 study, seeks to develop a prediction score assist in risk stratification KT recipients. In this 1379 patients (35 sites) were enrolled, and machine learning approach was used fit models derivation cohort. A reduced Elastic Net model selected, accuracy predict 28-day fatality after diagnosis, assessed by area under ROC curve (AUC-ROC), confirmed validation The better calibration values build applicable ImAgeS score....
This is a case series of 10 consecutive renal allograft recipients, followed at tertiary hospital in northeast Brazil, with confirmed diagnosis dengue. Five the patients needed hospitalization. Half them were males and age ranged from 19 to 60 years median 38.2 years. They had been transplanted for mean 5 days 166 months. Four developed dengue hemorrhagic fever (DHF). All myalgia headache. them, except one, fever. Positive serology (IgM) was found all patients. No patient died. Dengue an...
Visceral leishmaniasis is a disease caused by the protozoan Leishmania sp. and transmitted Lutzomyia longipalpis (sand fly). In renal transplant recipients, visceral causes severe damage to liver, spleen, hematopoietic system, as well poor outcomes for patients with transplanted kidneys. This study describes largest series of cases in providing important information about diagnostic routines therapeutic strategies this patient population.
Dengue is an arbovirosis that ranges from asymptomatic presentation to a more severe disease, which characterized by vascular leakage syndrome where abdominal pain major symptom. Transplant recipients are immunosuppressed and less likely develop form of the disease because reduction in immune-mediated responses trigger plasma extravasation events. Herein, we report two cases dengue early postoperative period kidney transplant recipients. Considering severity cases, emphasize importance...
Abstract Background This study aimed to evaluate renal function before, during, and after the course of tuberculosis ( TB ) disease in kidney transplant recipients, assess risk factors for non‐recovery baseline function. Methods We performed a retrospective, single‐center cohort study, including all patients with confirmed or presumed diagnosis (n=34, 2.1%). Renal was assessed by serum creatinine (Cr) glomerular filtration rate GFR adjusted deaths graft losses. Results A significant increase...
Background. The discard of expanded criteria donor (ECD) kidneys is unacceptably high, considering the growing demand for transplantation. Using machine perfusion may reduce rate, increase number transplants, and mortality on waiting list. Methods. We developed a 5-y Markov model to simulate incorporating pulsatile into current government-funded healthcare system. compared universal use static cold storage all with selective ECD kidneys. Real-life data were used compose cohort...
To describe the main anatomical variations of celiac trunk and hepatic artery at their origins.This was a prospective analysis 100 consecutive computed tomography angiography studies abdomen performed during one-year period. The findings were stratified according to classification systems devised by Sureka et al. Michels.The "normal" (i.e., hepatogastrosplenic superior mesenteric originating separately from abdominal aorta) in 43 patients. In our sample, we identified four types trunk....
BACKGROUND The present study analyzed the impact of hypothermic pulsatile machine perfusion (MP) following a long period static cold (SC) storage in peculiar Brazilian scenario high incidence delayed graft function (DGF), despite good donor characteristics. MATERIAL AND METHODS A retrospective analysis, with 1-year follow-up, 206 recipients donor-matched paired kidneys was performed. Of kidneys, 103 were maintained exclusively (SC group) and kept on after SC preservation (MP group). All...
The Brazilian collaborative registry for pediatric renal transplantation began in 2004 as a multicenter initiative aimed at analyzing, reporting, and disseminating the results of Brazil. Data from all transplants performed January to May 2018 13 participating centers were analyzed. A total 2744 thirteen centers. median age was 12.2 years, with majority being male recipients (56%). main underlying diseases CAKUT (40.5%) glomerulopathy (28%). 1981 (72%) grafts deceased donors (DD). Graft...
ABSTRACT Hemophagocytic syndrome or hemophagocytic lymphohistiocytosis (HLH) is an infrequent and underdiagnosed condition caused by overactive immune response, resulting in blood cells phagocytosis. After kidney transplantation (KTx), HLH usually secondary (or reactive) to infectious neoplastic processes has a high mortality rate. No effective treatment available for this condition. Usual procedures include detecting treating the pathology triggering system dysregulation, other than...
Protecting immunosuppressed patients during infectious disease outbreaks is crucial. During this novel coronavirus 2019 pandemic, preserving "clean areas" in hospitals assisting organ transplant recipients key to protect them and preserve transplantation activity. Evidence suggests that asymptomatic carriers might transmit the SARS-CoV-2, challenging implementation of transmission preventive strategies. We report a single-center experience using universal SARS-CoV-2 screening for all...
Endothelium is a known target of Covid-19. However, little about the effect chronic immunosuppression in modulating endothelial dysfunction. This study aimed to evaluate association between injury biomarkers and mortality solid organ transplant (SOT) recipients hospitalized due
Frailty phenotype is associated with adverse outcomes in chronic kidney diseases (CKD) and transplant (KT) patients. Data on frailty syndrome our region scarce. This study aimed to evaluate the prevalence of frailty, clinical laboratory characteristics, as well association disability cognitive impairment.
Kidney transplantation (KT) potentially reduces pulmonary damage associated with chronic kidney disease. This study explored this assumption by comparing functionality and endothelial function between dialysis KT patients.
This study evaluated the current practices of selecting cold storage preservation solutions in Brazil and their impact on delayed graft function (DGF) incidence 1-year outcomes kidney transplant recipients. A retrospective cohort was conducted, including 3,134 brain-dead deceased donor transplants performed between 2014 2015 18 Brazilian centers. The most commonly used solution Euro-collins (EC, 55.4%), followed by Histidine-tryptophan-ketoglutarate (HTK, 30%) Institut Georges Lopez (IGL-1,...
<b><i>Background:</i></b> In several countries, patients with end-stage renal disease who are ineligible for dialysis considered urgency priority (UP) kidney transplantation (KT) through distinct allocation rules. There scarce published data on clinical features and outcomes after KT of these patients. <b><i>Methods:</i></b> We retrospectively reviewed compared demographic pretransplant characteristics all transplanted under UP in a single...