A5072190306- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Parasites and Host Interactions
- Leptospirosis research and findings
- Insect and Pesticide Research
- Syphilis Diagnosis and Treatment
- Vector-borne infectious diseases
- Viral Infections and Vectors
- Brazilian cultural history and politics
- Vector-Borne Animal Diseases
- Insect Pest Control Strategies
- Mosquito-borne diseases and control
- Trace Elements in Health
- Poverty, Education, and Child Welfare
- Reproductive System and Pregnancy
- Global Public Health Policies and Epidemiology
- Diverse Music Education Insights
- HIV/AIDS Research and Interventions
- Antimicrobial Peptides and Activities
- Maternal and Neonatal Healthcare
- Toxin Mechanisms and Immunotoxins
- SARS-CoV-2 and COVID-19 Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Paraoxonase enzyme and polymorphisms
Universidade Federal do Piauí
2015-2024
Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais
2007-2024
Intel (United States)
2024
Universidade Estadual do Piau
2013-2023
Universidade Federal de Goiás
2017-2020
Ministry of Education
2018
Universidade Federal do Rio de Janeiro
2016
Ithaka Institute for Carbon Strategies
2015
Brazilian Society of Tropical Medicine
2012-2013
Universidade de Brasília
1975-2012
The kala-azar epidemic in the State of Piauí 1980-1986 is analyzed on basis data collected by SUCAM Piauí. outbreak began towns central and northern 1980. In contrast what has happened endemic periods which disease occurred areas higher altitude semi-arid climate, developed humid tropical river valleys rural zones. was worst towns. state capital, Teresina, hit 1981, reached peak 1984 accounted, for more than 60% 1,509 cases state. not substantial those regions sprayed to combat malaria...
Recent clinical data suggest that severe kala-azar (or visceral leishmaniasis) is an exaggerated innate immune response mediated by inflammatory cytokines, leading to a systemic syndrome similar what observed in malaria, sepsis and other diseases. We tested this hypothesis measuring serum cytokines individuals with kala-azar.We compared patients (i.e. hemorrhagic manifestations, n = 38) without evidence of hemorrhage (n 96). conducted detailed laboratory evaluation, IL-1beta, IL-6, IL-8,...
To analyze the temporal evolution of research on Neglected Tropical Diseases (NTDs) published by Journal Brazilian Society Medicine (JBSTM).We performed an analysis scientific production in JBSTM NTDs using advanced search, which included authors' descriptors, title, and abstract, combining specific terms for each from 1991 to 2021. Data related authors, countries origin, institutions, were evaluated analyzed over time. Bibliographic networks constructed VOSviewer 1.6.16.The 4,268 papers...
ABSTRACT Levels of the serum opsonin mannan-binding lectin (MBL) were directly correlated with probability developing visceral leishmaniasis. Monocytes infected MBL-opsonized Leishmania chagasi promastigotes secreted higher levels tumor necrosis factor alpha and interleukin-6 than cells nonopsonized parasites. Our findings indicate that MBL can modulate clinical outcome infection L. function macrophages.
In Brazil, programs based on elimination of infected dogs have not curtailed the spread visceral leishmaniasis (VL), suggesting that other reservoirs infection exist. Persons with active VL can infect sand fly vector, but in endemic areas, persons asymptomatic infections, whose infectivity to flies is unknown, are far more numerous. this study, a polymerase chain reaction-based assay detected kinetoplast DNA Leishmania chagasi blood eight 108 living patients recently diagnosed VL. These had...
Epidemics of visceral leishmaniasis (VL) in major Brazilian cities are new phenomena since 1980. As determinants transmission urban settings probably operate at different geographic scales, and information is not available for each scale, a multilevel approach was used to examine the effect canine infection environmental socio-economic factors on spatial variability incidence rates VL city Teresina. Details an outbreak greater than 1200 cases Teresina during 1993-1996 were two hierarchical...
The International Symposium on Leishmaniasis Vaccines, held in Olinda, Brazil, March 9–11, 2009, congregated international experts who conduct research vaccines against the leishmaniases. questions that were raised during meeting and ensuing discussions are compiled this report may assist guiding a agenda. A group to further discussion issues policy platform has been set up at http://groups.google.com/group/leishvaccines-l.
Sand flies deliver Leishmania parasites to a host alongside salivary molecules that affect infection outcomes. Though some proteins are immunogenic and have potential as markers of vector exposure, their identity specificity remain elusive.
INTRODUCTION: The objective of the study is to identify main risk factors for death by New World visceral leishmaniasis and establish a coherent pathogenic substrate severe disease based on clinical findings. METHODS: Seventy-six deceased inpatients 320 successfully treated with VL were studied in case control study. RESULTS: Bacterial infection bleeding mutually exclusive events leading death. Five unique bacterial (malnutrition, pulmonary rales, anemia, absolute neutropenia higher...
BackgroundMiltefosine has been used successfully to treat visceral leishmaniasis (VL) in India, but it was unsuccessful for VL a clinical trial Brazil.MethodsTo identify molecular markers that predict treatment failure whole genome sequencing of 26 L. infantum isolates, from cured and relapsed patients allowed GWAS analysis SNPs, gene chromosome copy number variations.FindingsA strong association identified (p = 0·0005) between the presence genetically stable Miltefosine Sensitivity Locus...
Background There is insufficient evidence to support visceral leishmaniasis (VL) treatment recommendations in Brazil and an urgent need improve current treatments. Drug combinations may be option. Methods A multicenter, randomized, open label, controlled trial was conducted five sites evaluate efficacy safety of (i) amphotericin B deoxycholate (AmphoB) (1 mg/kg/day for 14 days), (ii) liposomal (LAMB) (3 7 days) (iii) a combination LAMB (10 mg/kg single dose) plus meglumine antimoniate (MA)...
American visceral leishmaniasis (AVL) is associated with the absence of lymphocyte proliferative responses and interleukin (IL)-2 interferon-γ (IFN-γ) production upon stimulation Leishmania antigen. In contrast, cure AVL restoration these T cell functions. present study, ability IL-12, a cytokine that acts on NK cells to restore cellular immune in AVL, was evaluated. Participants study included 12 patients 7 subjects cured AVL. The [3H]thymidine uptake IFN-γ cultures peripheral blood...
Visceral leishmaniasis (VL) caused by Leishmania chagasi is a growing public-health problem in many parts of the New World. Although several studies have focused on consequences environmental damage, human migration and land occupation incidence VL, effects disease substandard living conditions that often result from process urbanization not been investigated detail. The present study was based Brazilian city Teresina, where, since 1980, there two large outbreaks VL (one 1981-1985 other...
The objective of this study was to identify socioeconomic and environmental factors associated with the incidence visceral leishmaniasis in city Teresina, Piauí State, Brazil. This an ecological based on 1,744 cases reported from 1991 2000, city's neighborhoods served as unit analysis. Mean annual rates were related demographic indicators a vegetation index derived remote sensing images by means spatial multiple linear regression models. highest mostly located peripheral areas. Multivariate...
Miltefosine was the first oral compound approved for visceral leishmaniasis chemotherapy, and its efficacy against Leishmania donovani has been well documented. amazonensis is second most prevalent species causing cutaneous main etiological agent of diffuse in Brazil. Driven by necessity finding alternative therapeutic strategies a chronic patient, we evaluated susceptibility to miltefosine line isolated from this who had not previously treated with miltefosine. In vitro tests promastigotes...
Drug-dosing recommendations for visceral leishmaniasis (VL) treatment are based on the patients' weight or age. A current lack of demographic and anthropometric data patients hinders (1) ability health providers to properly prepare patient management, (2) an informed drug procurement disease control, (3) design clinical trials development new therapies in different endemic areas. We present information about age, gender, weight, height 29,570 consecutive VL presenting 20 locations six...
Visceral leishmaniasis (VL) can be lethal if untreated; however, the majority of human infections with etiological agents are asymptomatic. Using Illumina Bead Chip microarray technology, we investigated patterns gene expression in blood active VL patients, asymptomatic infected individuals, patients under remission and controls. Computational analyses based on differential expression, set enrichment, weighted co-expression networks cell deconvolution generated data demonstrating...
The failure of control programs for visceral leishmaniasis (VL) that depend on elimination infected dogs suggests other reservoir hosts may participate in the transmission cycle. To determine whether persons with Leishmania chagasi can infect vector sand fly, laboratory-reared Lutzomyia longipalpis were allowed to feed Brazilian subjects active, cured, and asymptomatic VL residents houses active VL. Of 3747 insects had fed, 26 acquired infection from 11 44 VL, but none 137 persons. Among <4...
Bone marrow aspirates are believed to provide a safer but less sensitive method in the diagnosis of visceral leishmaniasis (VL) compared with splenic aspirates. We examined effect number fields and time observation on bone smear sensitivity it our experience spleen aspiration. smears 98 patients from 120 were examined. Among 87 VL, was 40.2%, 65.5%, 89.7%, 92%, 95.4% at 1, 5, 20, 30, 60 minutes, respectively. The aspirate examination 93% for 114 patients. One patient died shock after A is...