A5050505343- Renal Transplantation Outcomes and Treatments
- Pancreatic function and diabetes
- Organ Transplantation Techniques and Outcomes
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Transplantation: Methods and Outcomes
- Diabetes Management and Research
- Dialysis and Renal Disease Management
- Diabetes and associated disorders
- Neurological Complications and Syndromes
- Blood groups and transfusion
- Immune Cell Function and Interaction
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Renal and Vascular Pathologies
- Pharmacological Effects and Toxicity Studies
- Organ Donation and Transplantation
- Organ and Tissue Transplantation Research
- Hematopoietic Stem Cell Transplantation
- Polyomavirus and related diseases
- Public Health in Brazil
- Traumatic Brain Injury and Neurovascular Disturbances
- Xenotransplantation and immune response
- Drug-Induced Adverse Reactions
- Hepatitis C virus research
Hospital Moinhos de Vento
2020-2025
Pontifícia Universidade Católica do Rio Grande do Sul
2008-2020
Hospital São Lucas da PUCRS
2005-2016
University of Oxford
1995-2015
National Institute of Science and Technology
2012
Universidade Federal de São Paulo
2010
Universidade Federal do Rio Grande do Sul
1999-2007
Hospital de Clínicas de Porto Alegre
1999-2005
Santa Casa Hospital
2001-2004
John Radcliffe Hospital
1995-1997
Transplanted individuals in operational tolerance (OT) maintain long-term stable graft function after completely stopping immunosuppression. Understanding the mechanisms involved OT can provide valuable information about pathways to human transplantation tolerance. Here we report that operationally tolerant display quantitative and functional preservation of B-cell compartment renal transplantation. exhibited normal numbers circulating total B cells, naive, memory regulatory cells (Bregs) as...
To evaluate the pharmacokinetics of polymyxin B in patients on continuous venovenous haemodialysis (CVVHD) after intravenous administration unadjusted dosage regimens. Two critically ill had eight blood samples collected during a 12 h interval days 8 and 10 therapy. Dialysate was every hour dosing interval. Polymyxin binding plasma determined by rapid equilibrium dialysis. Concentrations dialysate were quantified using validated ultra-performance liquid chromatography-tandem mass...
<title>Abstract</title> Background: Cardiac troponin (c-TnT) levels are considered the gold standard for diagnosing acute coronary syndrome (ACS), particularly with advent of high-sensitivity assays (hs-TnT). However, its increased sensitivity can reduce specificity, in patients chronic kidney disease (CKD). This study aims to evaluate baseline hs-TnT (CKD) on hemodialysis and identify variables associated worse cardiovascular outcomes. Methods A prospective cohort was conducted CKD...
The combination of a depleting anti-Cd43monoclonal antibody (mAb) and single donor-specific transfusion before transplantation has been shown to induce operational tolerance in the majority cardiac allograft recipients mouse model. To examine protocol which might be more clinically relevant, we have modified this tolerance-inducing by substituting with nondepleting anti-Cd4 mAb. We show that form pretreatment can also immunologic unresponsiveness most (C3H/He, H2k), provided critical period...
OBJECTIVE: The present study was conducted to assess the association between depressive symptomatology and mortality in chronic hemodialysis. METHOD: A cohort of 40 patients followed for a median period 10.5 months. Beck Depression Inventory used classify as exposed depression (Beck score > 14) or not < 14). Kaplan-Meier survival curves were compare rate two groups. effects potential confounding factors adjusted using Cox proportional hazards model. RESULTS: After 24 months follow-up,...
One of the main postoperative complications kidney transplant is delayed graft function (DGF), which means absence after or need for dialysis during first week post procedure. The occurrence DGF currently in our hospital high and has been attributed to a combination many factors. aim this study was evaluate factors associated their influence outcome transplants.Historical cohort 150 patients transplanted with live deceased donor kidneys from 2011 2013.DGF time number recipient pre-transplant...
Contrast induced nephropathy is the third most prevalent preventable cause of acute kidney injury in hospitalized patients. It defined as an absolute increase serum creatinine ≥ 0.5 mg/dL and relative 25% increase.We studied risk factors to intravenous injection contrast after computed tomography.We 400 patients prospectively.The incidence nephropathy, with or a were 4.0% 13.9%, respectively. Diabetes cardiac failure independent for CIN de (O.R.: 3.5 [95% CI: 1.92-6.36], p < 0.01, 2.61...
Syngeneic cells expressing single donor MHC locus products have been shown to induce specific immunological hyporesponsiveness, but not tolerance, an allograft. In this study we attempted potentiate the beneficial effect of pretreatment with by addition anti-Cd42monoclonal antibody protocol. We show that recipient L a (K, D, or IA) can tolerance C57BL/10 (H2b) cardiac allograft in C3H/He(H2k) mice, when given combination depleting anti-Cd4 monoclonal YTA 3.1.2. Both induction and maintenance...
The association between the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and acute or chronic renal failure is well documented, but evidence such NSAIDs Contrast-Induced Nephropathies (CIN) not found in indexed literature.To evaluate possible CIN.In a cohort study, through clinical interviews patients that underwent cardiac catheterization, we analyzed its with development CIN, alterations serum creatinine glomerular filtration rate 48 72 hours.From July 2005 to 2006, 236 were...
ABSTRACT We describe a case of an adult organ recipient patient with pulmonary cavitary lesion due to Neisseria lactamica , harmless commensal organism that rarely causes human infection. To our knowledge, this is the first report disease caused by and second N. infection in patient.
Background: Operational tolerance (OT) is a state of graft functional stability that occurs after at least 1 year immunosuppressant withdrawal. MicroRNAs (microRNA) are small non-coding RNAs downregulate messenger RNA/protein expression innumerous molecules and critical for homeostasis. We investigated whether OT in kidney transplantation displays differential microRNA profile, which would suggest microRNAs participate Tolerance mechanisms, may reveal potential molecular pathways. Methods:...
Os modelos animais de diabetes têm sido usados extensivamente na obtenção do esclarecimentosobre esta doença. O objetivo deste estudo foi realizar uma revisão bibliográfica sobre os principaismodelos experimentais para o mellitus. Dentre oestudo diabetes, existem induzidos quimicamente por aloxana e streptozotocina, sendoque a dose utilizada depende da espécie animal seu peso. Além disso, dois excelentesmodelos espontâneo: ratos BB (Biobreading) camundongos NOD (Non ObeseDiabetic). são...
Highly active antiretroviral therapy has turned human immunodeficiency virus (HIV)-infected patients with end-stage renal disease into suitable candidates for transplantation. We present the Brazilian experience kidney transplantation in HIV-infected recipients observed a multicenter study.HIV-infected transplant and matched controls were evaluated incidence of delayed graft function (DGF), acute rejection (AR), infections, function, survival grafts.Fifty-three 106 enrolled. Baseline...