A5013809376- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Liver Disease Diagnosis and Treatment
- Organ Donation and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Transplantation: Methods and Outcomes
- Hepatitis B Virus Studies
- Neurological Complications and Syndromes
- T-cell and B-cell Immunology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Immune Cell Function and Interaction
- Polyomavirus and related diseases
- Genetic and Kidney Cyst Diseases
- Liver physiology and pathology
- Renal and Vascular Pathologies
- Pancreatic function and diabetes
- Congenital Anomalies and Fetal Surgery
- Liver Diseases and Immunity
- Tuberous Sclerosis Complex Research
- Gallbladder and Bile Duct Disorders
- Immunotherapy and Immune Responses
- Abdominal Trauma and Injuries
Massachusetts General Hospital
2016-2024
Harvard University
2023-2024
UMass Memorial Medical Center
2011-2023
Memorial Medical Center
2011-2023
University of Massachusetts Chan Medical School
2012-2021
UMass Memorial Health Care
2012-2021
NHS Blood and Transplant
2020
University of Groningen
2016-2019
Medical University of Vienna
2019
University Medical Center Groningen
2016-2019
A report from a high-volume single center indicated survival benefit of receiving kidney transplant an HLA-incompatible live donor as compared with remaining on the waiting list, whether or not deceased was received. The generalizability that finding is unclear.
Polyclonal antithymocyte globulin (ATG) is widely used as an anti-T-cell agent for induction and treatment of acute cellular rejection in solid organ transplantation. The authors recently demonstrated that rabbit (r) ATG can be combination with plasmapheresis to effectively treat antibody-mediated renal allograft rejection. This observation suggested rATG may have anti-B cell activity.The tested the complement-independent, apoptosis-inducing properties on CD27- naive B cells, CD40...
The liver protects the host from gut-derived pathogens yet is tolerant of antigenic challenge food and commensal sources. Innate responses involving macrophages (Kupffer cells) effector natural killer (NK) cells form first line in this defense. We address impact Toll-like receptor (TLR) signaling on cross talk between these two cells, reveal how displays a down-regulated inflammatory response to constitutive bacterial elements through secretion interleukin (IL) 10 retains vigorous viral...
Incompatible live donor kidney transplantation (ILDKT) offers a survival advantage over dialysis to patients with anti-HLA donor-specific antibody (DSA). Program-specific reports (PSRs) fail account for ILDKT, placing this practice at regulatory risk. We collected DSA data, categorized as positive Luminex, negative flow crossmatch (PLNF) (n = 185), flow, cytotoxic (PFNC) 536) or (PCC) 304), from 22 centers. tested associations between DSA, graft loss and mortality after adjusting PSR model...
The use of high-risk donor livers, which is reflective the gross national shortage organs available for transplantation, has gained momentum. Despite demand, many marginal livers are discarded annually. We evaluated impact center volume on survival outcomes associated with liver transplantation using high-donor risk index (DRI) allografts. queried Scientific Registry Transplant Recipients database deceased transplants (n = 31,576) performed between 2002 and 2008 patients who were 18 years...
Abstract Background Frail patients are more vulnerable to perioperative stressors of liver transplantation (LT). Program Specific Reports, used in transplant center auditing, risk‐adjust for frailty using the Karnofsky Performance Status ( KPS ) scale. We evaluate extent which functional impairment/disability is associated with increased risk postoperative death. Methods included 24 505 first‐time LT recipients from Scientific Registry Transplant Recipients (2006–2011). categorized as...
Donor safety has been scrutinized by both the medical community and media. Variability exists in reported donor complications associated risk factors are ill defined. Use of administrative data can overcome bias single-center studies explore variables with untoward events. A retrospective cohort study identifying living liver donors two large healthcare registries yielded 433 right left lobe from 13 centers between 2001 2005. Perioperative were identified using International Classification...
Abstract Background Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are the leading causes of hepatocellular carcinoma (HCC) worldwide. Limited data exist on surgical outcomes for NAFLD/NASH-related HCC compared with other etiologies. We evaluated differences in clinicopathological characteristics patients undergoing resection NAFLD/NASH-associated Methods Demographic, features, survival surgically resected were collected. NAFLD activity score (NAS)...
To assess how liver allografts preserved using portable normothermic machine perfusion (NMP) compare against those that underwent ischemic cold storage (ICS) in the setting of donation after brain death (DBD) and circulatory (DCD) transplantation (LT).
The immune tolerance induced by the liver as an allograft is difficult to reconcile with evidence that selectively accumulates activated T cells from circulation. However, much of this information based on murine lymphocytes were isolated using enzymatic digestion. In present study we made use a novel resource, during perfusion living donor lobe prior transplantation. These healthy human displayed surface markers indicating high degree activation natural killer cells, CD56(+) CD4(+) and...
Expansion of living kidney donation through liberalizing acceptance criteria invites a renewed focus on safety and outcomes. Wide variability exists in reported donor complications, associated risk factors are ill defined. Use administrative data can overcome the bias single-center studies identify variables with untoward events.The study population consisted 3074 donors from 28 centers during 2004 2005. Data large healthcare registry were used to retrospectively cohort. Perioperative...
The incidence of hepatocellular carcinoma (HCC) is on the rise worldwide as most common primary hepatic malignancy. In US approximately one half all HCC related to Hepatitis C virus (HCV) infection. relationship between disease and recurrence after liver transplantation unknown. We hypothesized that underlying development cirrhosis would be associated with risk recurrent transplantation. A retrospective review was conducted transplants performed at University Rochester Medical Center from...
Background. There has been concern that adult living-donor liver transplantation (LLTx) for hepatitis C virus (HCV) infection may lead to recurrent disease is more severe compared with the results of cadaveric LTx (CLTx), because smaller sized graft in LLTx regenerates and increase viral replication. This study examines survival outcome HCV recurrence CLTx versus performed at a single institution. Method. A total 100 consecutive recipients (75 men 25 women; mean age 49.9±8.4 years) (65 CLTxs...
Zand MS, Orloff Abt P, Patel S, Tsoulfas G, Kashyap R, Jain A, Safadjou Bozorgzadeh A. High mortality in orthotopic liver transplant recipients who require hemodialysis. Clin Transplant 2011: 25: 213–221. © 2010 John Wiley & Sons A/S. Abstract: Acute renal failure is a significant risk factor for death patients with failure. The goal of this study was to analyze the impact peri‐transplant dialysis on long‐term recipients. We performed single‐center, retrospective cohort 743 adult...
The success of adult right-lobe living donor liver transplants (RLDLT) would not have been possible without the experience early pioneers pediatric (LDLT). Our with 95 RLDLTs from July, 2000 to May, 2002 at a single institution is reported specific emphasis on arterial reconstruction. evolution technique using autogenous Y extension graft and reverse bifurcated for revascularization, which we believe has reduced incidence hepatic artery thrombosis, described. Outcome thrombosis are reported.