A5109945952- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Renal and Vascular Pathologies
- Liver Disease and Transplantation
- Transplantation: Methods and Outcomes
- Polyomavirus and related diseases
- Renal Diseases and Glomerulopathies
- Cytomegalovirus and herpesvirus research
- Pharmacological Effects and Toxicity Studies
- Organ and Tissue Transplantation Research
- Palliative Care and End-of-Life Issues
- Hepatitis C virus research
- Grief, Bereavement, and Mental Health
- Neurological Complications and Syndromes
- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- Antenna Design and Analysis
- Pneumocystis jirovecii pneumonia detection and treatment
- Parvovirus B19 Infection Studies
- T-cell and B-cell Immunology
- Congenital Anomalies and Fetal Surgery
- Immune Cell Function and Interaction
- HIV/AIDS Research and Interventions
- Blood donation and transfusion practices
Ho Chi Minh City Medicine and Pharmacy University
2025
Yueyang Hospital
2024
Shanghai University of Traditional Chinese Medicine
2024
Hunan University
2024
University of Pittsburgh
2005-2022
University of Pittsburgh Medical Center
2006-2021
Jamaica Hospital
2019
Hofstra University
2019
Feinstein Institute for Medical Research
2019
Thomas Jefferson University
2019
Although the impact of comorbidity on outcomes in ESRD has been evaluated extensively, its contribution after kidney transplantation not well studied. It is believed that assessment critical to informed interpretation transplant outcomes. In this study, Charlson Comorbidity Index was used assess comorbid conditions 715 patients who underwent at Starzl Transplant Institute between January 1998 and 2003. The pretransplantation development acute cellular rejection patient graft survival...
Severely obese patients who undergo orthotopic liver transplantation are likely to have higher morbidity, mortality, costs, and a lower long-term survival.This case-control study was done at university hospital. One hundred twenty-one consecutive underwent between 1994 1996 were studied. Severe obesity defined as body mass index (BMI) more than 95th percentile (>32.3 for women >31.1 men), moderate BMI 27.3 32.3 27.8 31.1 men. The outcome measures intraoperative complications, postoperative...
Postoperative morbidity, mortality, costs, and long-term survival in severely obese patients undergoing orthotopic liver transplantation
Abstract: Rabbit anti‐thymocyte globulin (ATG) and alemtuzumab have been used for induction or preconditioning the treatment of acute rejection in organ transplant recipients many centers. Such regimens may lead to a substantial decline CD4 lymphocyte count levels seen other population groups at high risk cryptococcosis. In view this, we examined impact such therapy on cumulative incidence cryptococcosis among liver kidney recipients. A total 834 727 transplants were performed during study...
There are no evidence-based interventions to prevent adverse psychosocial consequences after living donation. We conducted a single-site randomized controlled trial examine the postdonation impact of preventive intervention utilizing motivational interviewing (MI) target major risk factor for poor outcomes, residual ambivalence (i.e. lingering hesitation and uncertainty) about donating. Of 184 prospective kidney or liver donors, 131 screened positive ambivalence; 113 were (a) MI...
The purpose of this work was to perform kidney transplantation under a regimen immunosuppression that facilitates rather than interferes with the recently defined mechanisms alloengraftment and acquired tolerance.In almost all centers, multiple immunosuppressive agents are given in large doses after an attempt reduce incidence acute rejection near zero. With elucidation tolerance, it realized such heavy prophylactic could systematically subvert clonal exhaustion-deletion is seminal mechanism...
Alemtuzumab was used as an induction agent in 205 renal transplant recipients undergoing 207 living donor transplants. All kidneys were recovered laparoscopically. Postoperatively, patients treated with tacrolimus monotherapy, and immunosuppression weaned when possible. Forty-seven of transplants prior to the era who received conventional triple drug without antibody served historic controls. The mean follow-up 493 days alemtuzumab group 2101 control group. Actuarial 1-year patient graft...
OBJECTIVES: To examine the extent to which donor and recipient characteristics were associated with transplant outcomes in elderly kidney recipients. DESIGN: Retrospective review. SETTING: Single university center. PARTICIPANTS: One thousand one hundred two patients, including 266 patients aged 60 older. MEASUREMENTS: Recipient patient graft outcomes. RESULTS: Of 1,102 included this study, (25%) older, 117 (11%) 67 According Cox proportional hazards analysis, survival was worse recipients,...
ABSTRACT Knowledge of polyomavirus BK (BKV) genomic diversity has greatly expanded. The implications BKV DNA sequence variation for the performance molecular diagnostic assays is not well studied. We analyzed 184 publically available VP-1 sequences encompassing region targeted by an in-house quantitative hydrolysis probe-based PCR assay. A perfect match with primers and probe was seen in 81 sequences. One Dun 13 variant prototype oligonucleotides were synthesized as artificial targets to...
Mature teratomas of the duodenum are extremely rare, with only five cases reported in English literature and none documented Vietnam. Malignant transformation within a mature teratoma presents challenging scenario for diagnosis management, requiring nuanced approach to treatment.
Alemtuzumab has been used in off-label studies of solid organ transplantation.We analyzed the first 42 pediatric consecutive living donor kidney transplantations under alemtuzumab pretreatment with tacrolimus monotherapy and subsequent spaced weaning. We focused especially on causes recipient death graft loss characteristics rejection.Laparoscopic live-donor nephrectomy was associated no mortality delayed function. The actuarial 1, 2, 3, 4 years patient survivals were 97.6% 97.6%, 93.5%...
Transplant glomerulitis is an increasingly recognized lesion in renal transplant biopsies. To develop a refined grading system, we defined by the presence of ≥5 leukocytes/glomerulus and evaluated 111 biopsies using three different systems: (i) percentage glomerular involvement, (ii) peak inflammation most severely affected glomerulus (iii) presence/absence endocapillary occlusion inflammatory cells. Endocapillary had no impact on graft survival, but was associated with increased serum...
Induction with lymphocyte-depleting antibodies is routinely used to prevent rejection but often skews T cells toward memory. It not fully understood which memory and regulatory T-cell subsets are most affected how they relate clinical outcomes.We analyzed from 57 living-donor renal transplant recipients (12 reactive 45 quiescent) 2.8±1.4 years after alemtuzumab induction. Thirty-four healthy subjects nine patients acute cellular (ACR) were also studied.We found that caused protracted CD4...
The success of adult right-lobe living donor liver transplants (RLDLT) would not have been possible without the experience early pioneers pediatric (LDLT). Our with 95 RLDLTs from July, 2000 to May, 2002 at a single institution is reported specific emphasis on arterial reconstruction. evolution technique using autogenous Y extension graft and reverse bifurcated for revascularization, which we believe has reduced incidence hepatic artery thrombosis, described. Outcome thrombosis are reported.
End-stage renal disease (ESRD) is an increasing problem in patients infected with the human immunodeficiency virus (HIV). The use of highly active antiretroviral therapy (HAART) has decreased morbidity associated HIV and prompted renewed interest transplantation.We performed four cases deceased donor transplantation HIV+ recipients three where laparoscopic live nephrectomy (LLDN) was utilized to obtain kidney for into living-related recipients. In cases, conventional tacrolimus-based...
Alemtuzumab (Campath-1H) induction with tacrolimus monotherapy has been shown to provide effective immunosuppression for kidney, liver, lung, and small bowel transplantation. This drug combination was evaluated in pancreas transplant recipients.Sixty consecutive transplants (30 simultaneous pancreas-kidney, 20 after 10 alone) were carried out under this protocol between July 2003 January 2005. The mean follow-up 22 months (range 17-33).One-year patient, pancreas, kidney allograft survival...
The Cylex ImmuKnow Test (Cylex, Columbia, MD) measures immune cell function (ICF) and is based on the amount of adenosine triphosphate (ATP) released when T cells are stimulated by phytohemagglutinin. This preliminary study sought to determine if ICF measurements can be used stratify kidney transplant recipients according risk for developing BK virus infection. were done in 15 samples from 8 patients with viremia, 38 25 viruria, 243 148 no viruria or viremia. mean ± SD amounts ATP these 3...
Context Although some living donors experience psychological, somatic, and interpersonal difficulties after donation, interventions to prevent such outcomes have not been developed or evaluated. Objective To (1) summarize empirical evidence on psychosocial (2) describe a theoretical framework guide development of an intervention poor outcomes, (3) initial evaluation feasibility acceptability the intervention. Methods Based narrative literature review suggesting that individuals ambivalent...
Polyomavirus BK (BKV) infection characterized by viruria alone is considered to be of little clinical significance, but this issue has not been systematically studied.We studied 230 patients with sustained from whom multiple samples taken after a median 877 days (range, 24-2739) showed no progression viremia or nephropathy. Biopsies satisfying Banff thresholds for inflammation and tubulitis in the presence negative BKV stains were designated as putative T-cell-mediated acute...