A5013240461- Pleural and Pulmonary Diseases
- Lung Cancer Diagnosis and Treatment
- Ultrasound in Clinical Applications
- Respiratory Support and Mechanisms
- Trauma Management and Diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Respiratory viral infections research
- Long-Term Effects of COVID-19
- Pneumothorax, Barotrauma, Emphysema
- Tracheal and airway disorders
- COVID-19 diagnosis using AI
- Intensive Care Unit Cognitive Disorders
- Congenital Diaphragmatic Hernia Studies
- Cystic Fibrosis Research Advances
- Trauma and Emergency Care Studies
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Infectious Diseases and Mycology
- Airway Management and Intubation Techniques
- Lung Cancer Treatments and Mutations
- Anesthesia and Pain Management
- Amoebic Infections and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- SARS-CoV-2 detection and testing
Kettering General Hospital
2015-2024
Kettering General Hospital NHS Trust
2013-2024
Medway NHS Foundation Trust
2024
National Health Service
2024
University of Perpetual Help System DALTA
2023
Apollo Institute of Medical Sciences & Research
2023
Universidad Autónoma de Guadalajara
2023
Services Hospital
2023
MNR Medical College and Hospital
2023
Gujarat Cancer Society
2023
BackgroundPrimary spontaneous pneumothorax occurs in otherwise healthy young patients. Optimal management is not defined and often results prolonged hospitalisation. Data on efficacy of ambulatory options are poor. We aimed to describe the duration hospitalisation safety compared with standard care.MethodsIn this open-label, randomised controlled trial, adults (aged 16–55 years) symptomatic primary were recruited from 24 UK hospitals during a period 3 years. Patients randomly assigned (1:1)...
of clInIcal practIce poIntS Safety and preparation for pleural procedures► Before carrying out a procedure, safety should be taken into consideration. Research questions• Studies to investigate the role fibrinolytic treatment in septated effusion related IPC use MPE patients.• addressing single or dual stiches after insertion.
Introduction Local anaesthetic thoracoscopy (LAT) is an important step in the investigation of unexplained exudative pleural effusions. It increasingly performed as a day case procedure with indwelling catheter (IPC) insertion. Prospective data on complications unknown. We postulated that post-procedure surgical emphysema (SE) absence air leak not clinical problem. Some centres advocate concurrent IPCs and drains to promote drainage avoid SE. Methods note review patients undergoing LAT IPC...
The Coronavirus disease 2019 (COVID-19) pandemic is straining healthcare resources. Molecular testing turnaround time precludes having results at the point-of-care (POC) thereby exposing COVID-19/Non-COVID-19 patients while awaiting diagnosis. We evaluated utility of a triage strategy including FebriDx, 10-minute POC finger-stick blood test that differentiates viral from bacterial acute respiratory infection through detection Myxovirus-resistance protein A (MxA) and C-reactive (CRP), to...
<h3>Background</h3> There is a lack of data on the safety providing oxygen at home to stable patients recovering from COVID-19. <h3>Methods</h3> A retrospective analysis discharged COVID-19 virtual ward (CVW) between January 2021 and March UK district general hospital was performed. Patients with improving clinical trajectories requirements up 4 L/minute were eligible. Outcomes measured 30-day mortality readmission rate. <h3>Results</h3> From 02 16 (74 days), 147 CVW included: 71 received...
The optimal management of pneumothorax remains undefined. There is a growing consensus that patients with spontaneous can be considered for ambulatory the use one-way valve. Despite this, there little data on outcomes outpatient secondary (SSP).At our institution, selected primary and who meet predefined local criteria are managed an pathway. We prospectively evaluated practice over 3-year period explore SSP using (PSP) as comparator group.163 consecutive presenting to hospital between...
BACKGROUND: Ultrasound (US) guidance is widely used for needle positioning cervical medial branch blocks (CMBB) and radiofrequency ablation, however, limited research available comparing different approaches. OBJECTIVE: We aimed to assess the accuracy safety of 3 US-guided approaches CMBB. STUDY DESIGN: A cadaveric study divided into ultrasound-guided placement fluoroscopy evaluation stages. SETTING: Department Pathology, Forensic, Insurance Medicine, Semmelweis University. METHODS:...
This is a case report of an 84-year-old lady who presented with haemoptysis, weight loss and right hilar mass on chest radiograph. CT scan the revealed complete proximal occlusion upper lobe from endobronchial lesion consistent tumour. The patient was initially reluctant to undergo fibreoptic bronchoscopy as she deemed be unsuitable for any curative treatment lung carcinoma. Bronchoscopy showed exophytic necrotic tumour within lobe. Biopsies many bacterial colonies actinomyces diagnosis...
Cryptogenic Organising Pneumonia (COP) is a relatively rare condition and can be difficult to differentiate from Community acquired pneumonia (CAP). We report two cases which demonstrate the importance of considering this differential diagnosis in patients with spontaneous pneumothorax who have raised inflammatory markers or lung infiltrates. Our highlights value serum procalcitonin as biomarker differentiating between community cryptogenic organising especially context high C-reactive...
Vascular access is an important part of patient management in cystic fibrosis. In most instances, vascular straightforward. However, a single bad experience with venepuncture has lasting impact. Clinical suggested that for some individuals smaller, shorter intravenous catheter (Leaderflex 22G, 0.7 mm 8.0 cm, Vygon) might be suitable alternative to standard via long-line (2 Fr or 3 Nutriline, Vygon).Between September 2002 and May 2004 we offered free, fully informed choice between 30 cm long...
Background Differentiating viral from bacterial acute respiratory infections (ARIs) remains challenging, due to the non-specific clinical manifestations. The COVID-19 pandemic is putting extraordinary strain on healthcare resources. To date, molecular testing available but has a long turnaround time and therefore cannot provide results at point-of-care (POC) thereby exposing COVID-19/Non-COVID-19 patients each other while awaiting diagnosis. Methods This observational study prospectively...
Background: Sample adequacy for immediate molecular testing is paramount in lung cancer. To date, several endobronchial ultrasound with transbronchial needle aspiration (EBUS-TBNA) sampling setups have been evaluated, however, the utilization of high-pressure suction (HPS) has not yet reported. The aim this study was to evaluate HPS onto and its effect on sample volume patients suspected Methods: We retrospectively analyzed 128 consecutive EBUS-TBNA performed This confirmed 109 patients....
This is the first case in English language describing Achromobacter xylosoxidans a patient with idiopathic bronchiectasis. A 66-year-old man bronchiectasis presented shortness of breath to emergency department our institution, district hospital UK. His medications included long-term supplemental oxygen therapy and prophylactic azithromycin. Following 2 days admission respiratory unit, his saturations significantly deteriorated, was admitted intensive care type II failure. week intubation...
Background: The optimum management of respiratory failure in patients with coronavirus (COVID-19) infections has been a challenge for physicians across the globe. Many scientific societies have suggested use CPAP (continuous positive airway pressure) severe cases an effort to reduce invasive ventilation. We investigated mortality outcomes who needed but were not suitable Methods: retrospectively evaluated all consecutive COVID-19 type 1 requiring FiO2 >0.6 admitted our hospital between...
Background This study aims to examine the clinico-etiological profile of children with first episode a seizure and categorize types based on age groups in tertiary care hospital. Methodology was prospective observational conducted at medical institute India over two years. Children (one month 12 years age) were included population. The data collected demographic profile, history, examination, biochemical electroencephalogram (EEG), neuroimaging. categorized as generalized-onset, focal-onset,...
Secondary spontaneous pneumothorax can be difficult to manage especially in patients with advanced lung disease and respiratory failure. Such are unfit for surgery may endure prolonged hospital stays chest drains situ. We describe two such cases where the air leak was persistent despite conventional management. Ambulatory devices which we ordinarily use pneumothoraces a good reserve, were employed as palliative measure. The strategy not only allowed return home, but also resulted healing of...
Medical thoracoscopy with chemical pleurodesis is a last resort for managing patients who suffer. from recurrent hepatic hydrothorax. However, despite pleurodesis, the rapid fluid build-up can hinder successful apposition of pleural surfaces. To improve chances success, we investigated effectiveness abdominal paracentesis before via medical to reduce significant shifts peritoneal cavity. We present series three liver cirrhosis complicated by hydrothorax underwent talc pleurodesis. Before...
To assess the feasibility and safety of talc pleurodesis performed as part day-case medical thoracoscopy.
'Stage shift' has been proposed as a marker of impact Coronavirus 2019 (COVID-19) in lung cancer services; however, there are no data available specifically from income-deprived areas. Thus, this study evaluated the COVID-19 pandemic on care our area (Corby; among most income deprived England) and identified focus recovery The was retrospective observational 668 consecutive patients with at district general hospital, pre-, during after COVID peak. Outcomes were overall number cases,...
Mechanism of action EGFR mutationsThe role mutant epidermal growth factor receptor (EGFR) kinases in the a host human cancers including lung cancer is well known.The activation wild type primarily driven by binding factors leading to dimerisation.In this paper authors, through series simulation experiments, show that wildtype kinase domain intrinsically disordered and it becomes ordered (active) only upon dimerisation.This intrinsic disorder ( partial unfolding) third functionally important...
Abstract Background Reliable differentiation between uncomplicated and self-limiting acute respiratory tract infections (ARIs) more severe bacterial remains challenging, due to the non-specific clinical manifestations in both systemic or viral infections. The current COVID-19 pandemic is putting extraordinary strain on healthcare resources. To date, molecular testing available but has a long turnaround time therefore cannot provide results at point-of-care, leading delay thereby exposing...