A5069723334- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Surgical Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Regulation of Appetite and Obesity
- Genetic factors in colorectal cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
- Gallbladder and Bile Duct Disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroendocrine Tumor Research Advances
- Multiple and Secondary Primary Cancers
- Colorectal Cancer Screening and Detection
- Metastasis and carcinoma case studies
- Gastrointestinal motility and disorders
- Intestinal and Peritoneal Adhesions
- Organ Transplantation Techniques and Outcomes
- Enhanced Recovery After Surgery
- Renal Transplantation Outcomes and Treatments
- Pelvic and Acetabular Injuries
- Gastrointestinal Tumor Research and Treatment
- Gastroesophageal reflux and treatments
- Abdominal Trauma and Injuries
- Diet and metabolism studies
University Hospital Kralovske Vinohrady
2013-2024
Charles University
2015-2024
Amsterdam UMC Location University of Amsterdam
2023
Opća bolnica Karlovac
2012
Institute of Clinical and Experimental Medicine
2005-2010
Centrum kardiovaskulární a transplantační chirurgie
2005-2007
Institute of Bioorganic Chemistry
2006
Health First
2005
University Hospital Plzen
1999
The presence of circulating tumor cells (CTCs) in patients with metastatic carcinoma is generally associated poor clinical outcome. There have been many investigations showing a possible use CTCs as minimally invasive predictive and prognostic biomarker cancer medicine. In this report size-based method (MetaCell ® ) for quick easy enrichment cultivation presented to enable esophageal (EC) management. total, 43 diagnosed EC, 20 adenocarcinoma (AdenoCa) 23 squamous cell (SCC), were enrolled...
Circulating tumor cells (CTCs) are important targets for treatment and critical surrogate markers when evaluating cancer prognosis therapeutic response. A sensitive methodology detecting CTCs in gastric (GC) patients is needed. In this study we demonstrate a device enrichment cultivation of CTCs. total, 22 with GC, all candidates surgery, were enrolled the study. Peripheral blood samples collected before re-evaluated within operation divided into two groups: resectable non-resectable GC. new...
Leptin, an adipocyte-derived signaling factor, is a member of the IL-6 cytokine family. However there no direct evidence leptin stimulation acute phase protein (APP) synthesis which typical for all other IL-6-like factors. The purpose this study was to characterize dynamics circulating in relation ten APPs. We used postoperative septic patients as model network hyperstimulation and intensive APP reaction. prospective performed on 22 with proven intraabdominal sepsis after large abdominal...
Both ghrelin and leptin are important signals in the regulation of food intake energy balance. Leptin concentrations elevated majority obese individuals, its levels usually correlate with adiposity body mass index. Ghrelin as a new growth hormone (GH)-releasing peptide was discovered 1999. stimulates exhibits gastroprotective properties. Many other regulatory effects both involving cardiovascular, gastrointestinal, renal, endocrine systems were revealed. New experimental studies show...
The objective of the present report was to clarify postoperative stress response some inflammatory markers, namely proinflammatory cytokines and leptin levels during uncomplicated periods. results were compared with dynamics these parameters intraabdominal sepsis. We followed 20 patients after a planned resection colorectal cancer in stage Ib-IV healing 13 obese men laparoscopic non-adjustable gastric banding. These 12 proven control group consisted 18 healthy men. observed included serum...
Liquid biopsies are noninvasive tests using blood or body fluids to detect circulating tumor cells (CTCs) the products of cells, such as fragments nucleic acids proteins that shed into biological from primary its metastates. The analysis published clinical studies provides coherent evidence presence CTCs detected in peripheral is a strong prognostic factor patients with colorectal carcinoma (CRC). aim study was implement size-based separation protocol CRC patients.Patients diagnosed...
Plasma procalcitonin (PCT) is a highly specific marker for the diagnosis of bacterial infections and sepsis. PCT levels are usually low in viral infections, chronic inflammation or postsurgical states. The purpose this study was to characterize plasma patients with various types ileus at preoperative stage, where other inducing factors suchas surgical stress excluded. prospective performed on 54 admitted in-patient department proven ileus. Patients were divided three groups – obstructive,...
Ghrelin is a growth hormone-releasing peptide, discovered in 1999 by Kojima et al. Its potential role inflammation and stress response not yet clear. The purpose of this study was to characterize perioperative levels circulating ghrelin relation different surgical procedures. authors compared plasma changes with cortisol, cytokines, acute-phase proteins. prospective performed on 22 patients resection for colon cancer (group 1). Group 2, functioning as comparative group, consisted elective...
Aim of the study was to asses tumor grade prognostic value in Czech pancreatic cancer patients and evaluate accuracy TNMG model.Retrospective analysis 431 undergoing resection seven oncological centers between 2003 2013 performed.The impact model were evaluated.Lymph node status, size, stage proved as statistically significant survival predictors.The lower differentiation (grade 3 4) associated with poorer prognosis all stages (stage I: HR 2.23 [1.14; 4.36, CI 95%] p=0.019, II: 3.09 [2.01;...
Background/Aim: Pancreatic ductal adenocarcinoma (PDAC) still represents one of the most aggressive cancers. Understanding epithelial–mesenchymal crosstalk as a crucial part tumor microenvironment should pave way for therapies to improve patient survival rates. Well-established cell lines present useful and reproducible model study PDAC biology. However, tumor–stromal interactions between cancer cells cancer–associated fibroblasts (CAFs) are poorly understood. Materials Methods: We studied...
The research of novel implantable medical devices is one the most attractive, yet complex areas in biomedical field. design and development sufficiently small working an vivo environment challenging but successful encapsulation such even more so. Industry-standard methods using glass titanium are too expensive tedious, epoxy or silicone prone to water ingress with cable feedthroughs being frequent point failure. This paper describes a universal straightforward method for reliable circuit...
The aim of this study was to compare trends in mortality and incidence, clinicopathological features survival patients diagnosed with pancreatic ductal adenocarcinoma under 50 years age (early-onset cancer [EOPC]) over (late-onset [LOPC]).The national oncological registry the Czech Republic reviewed identify all histologically confirmed between 1985 2015. Incidence, mortality, data were analyzed compared EOPC LOPC.From a total 18 888 included study, 1324 (7.0%). average annual percentage...
The aim of this study was to investigate the use non-exposure endoscopic wall-inversion surgery (NEWS) and combination laparoscopic approaches neoplasia with technique (CLEAN-NET) in gastric tumors.We reviewed all cases NEWS CLEAN-NET performed department Royal Vinohrady Teaching Hospital.Our 12 tumor resections (NEWS, n=10 CLEAN-NET, n=2) between March 2016 February 2017. chosen for these included predominantly submucosal tumors no signs dissemination or local invasion early carcinomas...
Pulmonary endarterectomy (PEA) is an effective treatment for chronic thromboembolic pulmonary hypertension (CTEPH). The present study tested the hypothesis that inflammation, as determined by circulating cytokine levels, may contribute to difficulty in controlling arterial blood pressure after PEA.Thirty-six patients with CTEPH (22 males and 14 females) underwent PEA using cardiopulmonary bypass (CPB) deep hypothermic circulatory arrest. Plasma concentrations of tumor necrosis factor alpha,...
Therapy for pancreatic ductal adenocarcinoma remains challenging, and the chances of a complete cure are very limited. As in other types cancer, expression role miRNAs controlling biological properties this type tumor have been extensively studied. A better insight into miRNA biology seems critical to refining diagnostics improving their therapeutic potential. In study, we focused on miR-21, -96, -196a, -210, -217 normal fibroblasts, cancer-associated fibroblasts prepared from pancreas,...