A5101805570- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Hematological disorders and diagnostics
- Lymphoma Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders Research
- Fungal Infections and Studies
- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Hemoglobinopathies and Related Disorders
- Cytokine Signaling Pathways and Interactions
- Tumors and Oncological Cases
- Blood groups and transfusion
- Spondyloarthritis Studies and Treatments
- Hemodynamic Monitoring and Therapy
- Eosinophilic Disorders and Syndromes
- Bone and Joint Diseases
- Biotin and Related Studies
- Rabies epidemiology and control
- Pluripotent Stem Cells Research
- Oral Health Pathology and Treatment
- Iron Metabolism and Disorders
- Oral and Craniofacial Lesions
- Developmental Biology and Gene Regulation
- Neuroblastoma Research and Treatments
University of Manchester
2020-2025
Versus Arthritis
2020-2025
NIHR Manchester Biomedical Research Centre
2023-2025
Manchester University NHS Foundation Trust
2024-2025
Genomics (United Kingdom)
2021-2024
Manchester Academic Health Science Centre
2022-2024
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2005-2024
Centre for Epidemiology Versus Arthritis
2020-2022
Royal Lancaster Infirmary
2022
Dr. Rajendra Prasad Government Medical College
2016-2021
A number of homeodomain proteins have been shown to regulate cellular development by stimulating the transcription specific target genes. In contrast their distinct activities in vivo, however, most bind indiscriminately potential sites vitro, suggesting involvement cofactors which specify site selection. One such cofactor, termed extradenticle, has influence segmental morphogenesis Drosophila melanogaster binding cooperatively with certain regulatory elements. Here we demonstrate that...
A novel 913-amino acid protein, γ-aminobutyric type (GABAA) receptor interacting factor-1 (GRIF-1), has been cloned and identified as a GABAAreceptor-associated protein by virtue of its specific interaction with the GABAA β2 subunit intracellular loop in yeast two-hybrid assay. GRIF-1 no homology proteins known function, but it is rat orthologue human ALS2CR3/KIAA0549 gene. expressed two alternative splice forms, GRIF-1a C-terminally truncated form, GRIF-1b. mRNA wide distribution major...
Objectives The sparse effector “omnigenic” hypothesis postulates that the polygenic effects of common SNPs on a typical complex trait are mediated by trans ‐ coalesce expression relatively set core genes. objective this study was to identify genes for rheumatoid arthritis testing association with genome‐wide aggregated (GATE) scores each gene as transcript in whole blood or circulating protein levels. Methods GATE were calculated 5400 cases and 453705 non‐cases primary UK Biobank...
The commitment of cells to specific lineages during development is determined in large part by the relative expression various homeodomain (HOX) selector proteins, which mediate activation distinct genetic programs. But mechanisms individual HOX genes are themselves targeted for different cell types remain largely uncharacterized. Here, we demonstrate that STF-1, a protein functions pancreatic morphogenesis and glucose homeostasis encoded an “orphan” homeobox gene on mouse chromosome 5. When...
Peri-operative monitoring of coagulation is important to diagnose potential cause hemorrhage, manage coagulopathy and guide treatment with blood products in patients undergoing cardiac surgery cardiopulmonary bypass. This study was done evaluate usefulness Thromboelastography (TEG) routine tests (RCT) assessing hemostatic changes predicting postoperative bleeding bypass.Fifty adult bypass were enrolled this prospective study. Preoperative post-operative samples collected for TEG. Regression...
Objective There is growing evidence that genetic data are of benefit in the rheumatology outpatient setting by aiding early diagnosis. A probability tool (G‐PROB) has been developed to aid diagnosis not yet tested a real‐world setting. Our aim was assess whether G‐PROB could using from Norfolk Arthritis Register (NOAR), prospective observational cohort patients presenting with inflammatory arthritis. Methods Genotypes and clinician diagnoses were obtained NOAR. Six G‐probabilities (0%–100%)...
Abstract Background Haplotypes defined by amino acids at HLA-DRB1 positions 11, 71 and 74 associated with susceptibility to rheumatoid arthritis (RA) are radiological outcome, anti-TNF response all cause-mortality in RA. RA is cardiovascular (CV) morbidity mortality, but the increased prevalence of risk factors CV disease only partially explains this association. The aim study was investigate whether mortality inflammatory polyarthritis (IP). Methods Norfolk Arthritis Register (NOAR) an...
<br>Systemic oxalosis can be either primary or secondary hyperoxaluria. Oxalosis is a phenomenon in which calcium oxalate crystals deposit various visceral organs leading to bone marrow (BM) failure and recurrent renal stones. We describe two rare cases of BM oxalosis. Hyperoxaluria strongly associated with nephrolithiasis nephrocalcinosis. Both the patients presented stones variable degree failure. should considered as possible diagnosis cytopenia.<br>
Introduction: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease with various clinical manifestations and approximately 50% of the SLE patients develop nephritis (LN), which increases risk renal failure, cardiovascular diseases overall survival. Objectives: Evaluation neutrophil-derived parameters (Neut-X, Neut-Y Neut-Z) as an inflammatory, activity marker predictor in patients. Material Methods: In this cross-sectional study, 3 ml K3EDTA blood was taken from 110...
Varicella Zoster Virus (VZV) infections are considered to be mild and ubiquitous predominantly affecting the pediatric population. However, in adults immunocompromised patients, this apparently benign self-limiting course can have protean complications with a rapidly downhill course. We present rare case report of young individual probably compromised immune system who had fulminant VZV infection complicated disseminated intravascular coagulation (DIC) resulting death.