A5046529006- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Chronic Lymphocytic Leukemia Research
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Cytokine Signaling Pathways and Interactions
- Lymphoma Diagnosis and Treatment
- interferon and immune responses
- Biosimilars and Bioanalytical Methods
- Inflammatory Bowel Disease
- CAR-T cell therapy research
- Single-cell and spatial transcriptomics
- Viral Infections and Immunology Research
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders Research
- Advanced Biosensing Techniques and Applications
- Immunodeficiency and Autoimmune Disorders
University of Manchester
2020-2025
Versus Arthritis
2020-2023
Manchester Academic Health Science Centre
2022-2023
Objectives The sparse effector “omnigenic” hypothesis postulates that the polygenic effects of common SNPs on a typical complex trait are mediated by trans ‐ coalesce expression relatively set core genes. objective this study was to identify genes for rheumatoid arthritis testing association with genome‐wide aggregated (GATE) scores each gene as transcript in whole blood or circulating protein levels. Methods GATE were calculated 5400 cases and 453705 non‐cases primary UK Biobank...
Abstract Background Despite the increase in novel medications for Crohn’s disease (CD), many patients either fail to respond adequately to, or are intolerant of current drugs. Cell therapies have yet a significant impact IBD but represent potential treatment option. Regulatory T-cells (Tregs) play key role immune homeostasis, and Treg dysfunction is implicated pathogenesis CD. Their therapeutic has not been assessed humans with We designed Phase 1b study explore feasibility using novel,...
Despite the report of an imbalance between CD4+ T helper (Th) cell subsets in rheumatoid arthritis (RA), patient stratification for precision medicine has been hindered by discovery ever more Th subsets, as well contradictory association results.To capture previously reported RA with deep immunophenotyping techniques; to compare hypothesis-free unsupervised automated clustering hypothesis-driven conventional biaxial gating and explore if heterogeneity accounts conflicting...
No reliable biomarkers to predict response TNF inhibitors (TNFi) in RA patients currently exist. The aims of this study were replicate changes gene co-expression modules that previously reported TNFi therapy RA; test if module expression are specific therapy; and determine whether transitions towards a disease-free state responding patients.Published transcriptomic data from the whole blood controls (n = 10) patients, treated with adalimumab 70) or methotrexate 85), studied. Treatment was...
Abstract Background/Aims Tumour necrosis factor inhibitors (TNFi) have advanced the clinical management of rheumatoid arthritis (RA); however, only 30-40% patients who receive initial treatment with a TNFi experience beneficial response. The discovery biomarkers response would facilitate improved rates and more objective monitoring inflammation. Gene transcript levels measured in blood RA represent an attractive source biomarkers. For example, study by Oswald et al demonstrated reproducible...
Abstract Background/Aims The use of tumour necrosis factor inhibitors (TNFi) has advanced the clinical management rheumatoid arthritis (RA). However, only 30-40% patients who receive initial treatment with a TNFi experience beneficial response. discovery reliable biomarkers response is, therefore, priority. Whilst T-cell dysfunction is documented in RA pathophysiology, involvement unclear. We aimed to phenotype peripheral blood-derived T-cells over number time-points through first 12-weeks...
Abstract Background/Aims Treating rheumatoid arthritis (RA) continues to rely heavily on a trial-and-error approach. The potential of deep immunophenotyping peripheral blood remains be proven in tailoring treatment an individual’s biological variability. Here, we aim compare the analysis single-cell data using unsupervised automated clustering approach with conventional biaxial gating identify T cell imbalances RA. Methods Unstimulated and stimulated mononuclear cells from 10 RA healthy...
Abstract Background Despite the report of an imbalance between CD4 + T helper (Th) cell subsets in rheumatoid arthritis (RA), patient stratification for precision medicine has been hindered by discovery ever more Th subsets, as well contradictory association results. Objectives To capture previously reported RA with deep immunophenotyping techniques; to compare hypothesis-free unsupervised automated clustering hypothesis-driven conventional biaxial gating and explore if heterogeneity...