A5034323187- Epigenetics and DNA Methylation
- Risk and Portfolio Optimization
- Telomeres, Telomerase, and Senescence
- Bayesian Methods and Mixture Models
- Carcinogens and Genotoxicity Assessment
- Statistical Distribution Estimation and Applications
- Financial Reporting and Valuation Research
- Genomics and Chromatin Dynamics
- CRISPR and Genetic Engineering
- Probability and Risk Models
- MicroRNA in disease regulation
- Gene expression and cancer classification
- DNA Repair Mechanisms
- Geochemistry and Geochronology of Asian Mineral Deposits
- Stock Market Forecasting Methods
- Geochemistry and Geologic Mapping
- Histone Deacetylase Inhibitors Research
- Monoclonal and Polyclonal Antibodies Research
- Geoscience and Mining Technology
- Economic theories and models
- Medical Coding and Health Information
- Cancer-related molecular mechanisms research
- Statistical Mechanics and Entropy
- Credit Risk and Financial Regulations
- Lung Cancer Treatments and Mutations
Zhejiang Sci-Tech University
2008-2024
Donghua University
2024
University of Science and Technology of China
2013-2023
Guangxi Medical University
2021
Henan University
2021
Centers for Disease Control and Prevention
2014
Shenzhen Center for Disease Control and Prevention
2010-2014
Thermo Fisher Scientific (Norway)
2013
CrossLife Technologies (United States)
2011
Tianjin Geothermal Exploration, Development and Design Institute (China)
2011
Nickel (Ni) compounds are potent carcinogens and can induce malignant transformation of rodent human cells. To uncover the molecular mechanisms nickel sulfide (NiS)-induced cell transformation, we investigated epigenetic alterations in a set DNA repair genes. The silencing O(6)-methylguanine methyltransferase (MGMT) gene locus upregulation 1 (DNMT1) expression was specifically detected NiS-transformed bronchial epithelial (16HBE) In addition, noted including hypermethylation, reduced histone...
Abstract It is of great significance to develop a novel approach treat bacterial infections, as the frequent misuse antibiotics leads serious problem resistance. This study proposed antibiotic-free antibacterial nanoparticles for eliminating methicillin-resistant Staphylococcus aureus (MRSA) based on multi-model synergistic ability chemodynamic therapy (CDT), photothermal effect, and innate immunomodulation. Specifically, polydopamine (PDA) layer coated Ag loaded core-shell structure Fe 3 O...
G protein coupled receptors (GPCRs) represent the largest family of membrane proteins in human genome and richest source targets for pharmaceutical industry. A major limitation to characterizing GPCRs has been difficulty developing high-level heterologous expression systems that are cost effective. Reasons these difficulties include inefficient transport insertion plasma cytotoxicity. Additionally, GPCR purification requires detergents, which have a negative effect on receptor yields...
The relation between extropy and variational distance is studied in this paper. We determine the distribution which attains minimum or maximum among these distributions within a given variation from any probability distribution, obtain tightest upper bound on difference of extropies two subject to constraint, establish an analytic formula for confidence interval extropy. Such study parallels that Ho Yeung [3] concerning entropy. However, proofs main results paper are different those [3]. In...
CYP2E1 catalyzes the metabolic activation of tobacco‐specific N ‐nitrosamines, including 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone. An Rsa I polymorphism, which is located in 5′‐flanking region gene, has been found to affect transcriptional regulation resulting different expression levels mRNA among individuals. In order investigate an association between polymorphism and lung cancer susceptibility, genotype distribution 316 patients was compared with that 503 healthy controls. No...
Transcription activator-like effectors (TALEs), secreted by the pathogenic bacteria Xanthomonas, specifically activate expression of targeted genes in plants. Here, we designed synthetic TALEs that bind to flanking regions TATA-box motif on CaMV 35S promoter for purpose understanding engineerable 'hot-spots' increasing transgene expression. We demonstrated transient de novo-engineered using agroinfiltration could significantly increase reporter gene stable transgenic tobacco expressing...
Trichloroethylene (TCE), an important volatile organic solvent, causes a series of toxic damage to human. Conventional genetic mechanisms cannot fully explain its toxicity and carcinogenicity, indicative the possible involvement epigenetic mechanisms. Our study was intended investigate underlying TCE. Data showed that 0.3 mM TCE treatment for 24 h increased growth L-02 cells transiently. In contrast, subacute exposure inhibited cell induced genomic DNA hypomethylation histone...
Histone modifications are major post-translational mechanisms responsible for regulation of gene transcription involved in cellular senescence. By using immunofluorescence and Western blot, we showed that the global acetylated levels histone H3 H4 were significantly reduced both replicative premature senescence human embryonic lung fibroblasts. However whole trimethylated level lysine 20 was higher senescent cells. The alterations mRNA protein acetyltransferases (HATs), methyltransferase...
1. The present study investigated the therapeutic effects of both single and combination treatment with Yunke (technetium-99 conjugated methylene diphosphonate; (99)Tc-MDP) colloidal chromic phosphate (32)P (phosphonium-32) in rats adjuvant arthritis (AA). 2. Rats were randomly allocated to one five groups: (i) normal control group (sham operated treated saline); (ii) AA (arthritis induced (iii) colloid a intra-articular injection phosphonium-32 (0.02 mCi) i.p. injections saline every other...
Almost stochastic dominance has been receiving a great amount of attention in the financial and economic literatures. In this paper, we characterize properties almost first-order (AFSD) via distorted expectations investigate conditions under which AFSD is preserved distortion transform. The main results are also applied to establish comparisons order statistics receiver operating characteristic curves AFSD.
Trichloroacetic acid (TCA) is a common non-volatile by-product of chlorination disinfection for drinking water. It necessary to know the epigenetic toxicity and mechanisms establishing safe exposure limit environmental TCA exposure. This study explored histone modification variations TCA-treated human hepatocytes L-02 at different time concentrations. (0.1 mM, 0.3 mM 0.9 mM) had an inhibitory effect on growth cells, with no significant changes in morphology. Treated 24 h 48 h, cells showed...
Low-temperature and low-salt fermented Chinese kohlrabi (LSCK) represents a novel approach to producing without the need for desalination during processing, as compared traditional techniques. However, profile of its non-volatile metabolites remains unclear. In order investigate their changes in LSCK fermentation, LSCKs 0 day (0D), 45 days (45D) 90 (90D) were analyzed using LC-MS/MS non-targeted metabolomics coupled with multivariate statistical analysis. The results showed that 60, 74, 68...
To complement the conventional area under ROC curve (AUC) which cannot fully describe diagnostic accuracy of some non-standard biomarkers, we introduce a transformed and its associated AUC (TAUC) in this article, show that TAUC can relate original improper biomarker to proper after non-monotone transformation. We then provide nonparametric estimation transformation TAUC, establish their consistency asymptotic normality. conduct extensive simulation studies assess performance proposed method...