A5033084479- Hematopoietic Stem Cell Transplantation
- Immune cells in cancer
- Erythrocyte Function and Pathophysiology
- Acute Myeloid Leukemia Research
- Angiogenesis and VEGF in Cancer
- Hematological disorders and diagnostics
- Immune Response and Inflammation
- Bone and Joint Diseases
- Chemokine receptors and signaling
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immunotherapy and Immune Responses
- Neonatal Respiratory Health Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- T-cell and B-cell Immunology
- Chronic Lymphocytic Leukemia Research
- Single-cell and spatial transcriptomics
- Immune Cell Function and Interaction
- Blood properties and coagulation
- Digital Imaging for Blood Diseases
- Platelet Disorders and Treatments
Cincinnati Children's Hospital Medical Center
2018-2025
University of Cincinnati Medical Center
2020-2024
Children's Medical Center
2018-2021
University of Michigan
2016-2017
The bone marrow adjusts blood cell production to meet physiological demands in response insults. spatial organization of normal and stress responses are unknown owing the lack methods visualize most steps production. Here we develop strategies image multipotent haematopoiesis, erythropoiesis lymphopoiesis mice. We combine these with imaging myelopoiesis
ABSTRACT The bone marrow has an extraordinary capacity to adjust blood cell production meet physiological demands in response insults. spatial organization of normal and stress responses is largely unknown due the lack methods visualize most steps production. Here we develop strategies image multipotent hematopoiesis, megakaryopoiesis, erythropoiesis, lymphopoiesis mice. We combine these with imaging myelopoiesis 1 define anatomy hematopoiesis homeostasis, after acute insults, during...
Summary In contrast to virtually all other tissues in the body anatomy of differentiation bone marrow remains unknown. This is due lack strategies examine blood cell production situ, which are required better understand differentiation, lineage commitment decisions, and define how spatial organizing cues inform tissue function. Here we developed imaging approaches map myeloid cells whole bones generated 3D atlases granulocyte monocyte/dendritic during homeostasis. We found that progenitors...