A5081228601- Scoliosis diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Congenital heart defects research
- Coronary Artery Anomalies
- Congenital Heart Disease Studies
- Pelvic and Acetabular Injuries
- Spine and Intervertebral Disc Pathology
- Pregnancy-related medical research
- Bone fractures and treatments
- Connective tissue disorders research
- Tissue Engineering and Regenerative Medicine
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Congenital Diaphragmatic Hernia Studies
- Cardiac Fibrosis and Remodeling
- Trauma and Emergency Care Studies
- Genomic variations and chromosomal abnormalities
- Cervical and Thoracic Myelopathy
- Cardiovascular Conditions and Treatments
- Congenital Anomalies and Fetal Surgery
- Hip disorders and treatments
- Esophageal and GI Pathology
- Pediatric Urology and Nephrology Studies
- Marine animal studies overview
University Medical Center Utrecht
2016-2022
Children's Hospital of Philadelphia
2018
22q11.2 deletion syndrome (22q11.2DS) is a disorder caused by recurrent, chromosome‐specific, low copy repeat (LCR)–mediated copy‐number losses of chromosome 22q11. The Children's Hospital Philadelphia has been involved in the clinical care individuals with what now known as 22q11.2DS since our initial report association DiGeorge 1982. We reviewed medical records on continuously growing longitudinal cohort 1,421 patients molecularly confirmed from 1992 to 2018. Most are Caucasian and older...
Abstract Purpose Blunt cerebrovascular injuries (BCVI), which can result in ischemic stroke, are identified 1–2% of all blunt trauma patients. Computed tomography angiography (CTA) scanning has improved and is the diagnostic modality choice BCVI suspected Data about long-term functional outcomes incidence stroke after limited. The aim this study was to determine relation imaging improvements outcomes. Methods All consecutive patients from 2007 2016 with were level 1 center prospective...
The 22q11.2 deletion syndrome (22q11.2DS) is the most common microdeletion in humans. It characterised by wide phenotypic variability, including congenital heart disease (CHD), immunodeficiency and scoliosis. However, little known regarding prevalence characteristics of scoliosis patients with 22q11.2DS. objective this study to assess scoliosis, its association CHD 22q11.2DS.This based on physical examination questionnaires world's largest 22q11.2DS longitudinal collected database (n=1393,...
To define the longitudinal rotation axis around which individual vertebrae rotate, and to establish various extra- intravertebral patterns in thoracic adolescent idiopathic scoliosis (AIS) patients, for better understanding of 3D development rotational deformity.Seventy high-resolution CT scans from an existing database AIS patients (Cobb angle: 46°-109°) were included determine vertebral axial rotation, radius, local mechanical torsion each spinal level, using previously validated image...
Background: The development of proximal junctional kyphosis (PJK) after posterior spinal fusion in adolescent idiopathic scoliosis is a major problem. Changes the global sagittal parameters as they relate to PJK have been reported surgery, however, relationships between changes upper-instrumented vertebra (UIV) during and surgery not quantified. We hypothesize that compensatory unfused segments spine over time are correlated with surgically induced UIV position. Methods: Sixty patients (with...
Abstract Purpose There are distinct differences in strategy amongst experienced surgeons from different ‘scoliosis schools’ around the world. This study aims to test hypothesis that, due 3-D nature of AIS, strategies can lead coronal, axial and sagittal curve correction. Methods Consecutive patients who underwent posterior scoliosis surgery for primary thoracic AIS were compared between three major centres ( n = 193). Patients treated according local surgical expertise: Two perform primarily...
Study Design. Cross-sectional. Objective. The aim of this study was to analyze the thoracic center mass (COM) position children at different ages and evaluate its relation with previously reported pre-existent rotational pattern normal spine. Summary Background Data. normal, nonscoliotic spine is known have a that changes direction during growth, transition from left-sided toward right-sided rotation increasing age. This matches changing curve convexity seen when idiopathic scoliosis...
The 22q11.2 Deletion Syndrome (22q11.2DS) occurs in ~1:3,000–6,000 individuals. Features less typically associated with 22q11.2DS, such as orthopedic manifestations, may be overlooked or not lead to appropriate diagnostic testing. Club foot has a general population prevalence of ~1:1,000 and been occasionally described association 22q11.2DS. Our hypothesis is that the club higher patients We performed retrospective review two specialized 22q11.2DS centers determine foot. “True foot” requires...
Adolescent idiopathic scoliosis (AIS), defined as a lateral deviation of the spine at least ten degrees, is classic enigma in orthopaedics and affects 1–4% general population. Despite (over) century intensive research, etiology still largely unknown. One major problems all existing AIS research fact that most patients come to medical attention after onset curve. Therefore, it impossible know whether current investigated parameters are causative, or an effect scoliosis. Moreover, up until now...
To better understand the etiology of idiopathic scoliosis, prospective research into pre-scoliotic state is required, but this practically impossible to carry out in general population. The use 'models', such as idiopathic-like scoliosis established genetically modified animals, may elucidate certain elements, their translatability human situation questionable. 22q11.2 deletion syndrome (22q11.2DS), with a 20-fold increased risk developing be valuable and more relevant alternative serve...
Abstract Study design Cross-sectional. Objectives To determine semiautomatically the 3D position of pedicle axis in operative adolescent idiopathic scoliosis (AIS) patients relative to operating table and lamina, as orientation for screw placement better understanding reference spine surgeons. Summary background data Pedicle morphology is well described angle between convex concave pedicle. However, neutral anterior–posterior or an easy-to-use intravertebral landmark, remained unknown....
Abstract Scoliosis is a deformation of the spine that may have several known causes, but humans are only mammal to develop scoliosis without any obvious underlying cause. This called ‘idiopathic’ and most common type. Recent observations showed human scoliosis, regardless its cause, has relatively uniform three-dimensional anatomy. We hypothesize universal compensatory mechanism spine, independent cause and/or species. had opportunity study rare occurrence in whale ( Balaenoptera...
To use computed tomography (CT) to assess the validity and reliability of posterior landmarks, spinous processes (SP), transverse (TP), centre lamina (COL), as compared Cobb angle curve severity progression adolescent idiopathic scoliosis (AIS).A consecutive series CT examinations severe AIS patients were included retrospectively. SP, TP, COL angles measured for all curves angle.One hundred five included. The mean versus were, 54° 37°, 49°, 51° in thoracic 34° 26°, 31°, (thoraco)lumbar...
Abstract Scoliosis is a deformation of the spine that may have several known causes, but humans are only mammal to develop scoliosis without any obvious underlying cause. This called ‘idiopathic’ and most common type. Recent observations showed human scoliosis, regardless its cause, has relatively uniform three-dimensional anatomy. We hypothesize universal compensatory mechanism spine, independent cause and/or species. had opportunity study rare occurrence in whale ( Balaenoptera...