A5054854740- COVID-19 Clinical Research Studies
- Kawasaki Disease and Coronary Complications
- COVID-19 Impact on Reproduction
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Intensive Care Unit Cognitive Disorders
- Gut microbiota and health
- Sepsis Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Pneumonia and Respiratory Infections
- Child and Adolescent Health
- Clinical practice guidelines implementation
- Acute Kidney Injury Research
- Hip and Femur Fractures
- Dermatological and COVID-19 studies
- Mechanical Circulatory Support Devices
- Gastrointestinal motility and disorders
- Injury Epidemiology and Prevention
- COVID-19 and healthcare impacts
- Inflammasome and immune disorders
- Parasitic infections in humans and animals
- Autopsy Techniques and Outcomes
- Pharmaceutical studies and practices
Children's Hospital of Philadelphia
2020-2025
Nemours Children's Health System
2023-2025
University of Alabama at Birmingham
2022
Society of Critical Care Medicine
2021-2022
Office of Infectious Diseases
2020
University of Pennsylvania
2020
Philadelphia University
2020
Rainbow Babies & Children's Hospital
2018-2019
Case Western Reserve University
2018
George Washington University
2015-2016
BACKGROUND. Initial reports from the severe acute respiratory coronavirus 2 (SARS–CoV-2) pandemic described children as being less susceptible to disease 2019 (COVID-19) than adults. Subsequently, a and novel pediatric disorder termed multisystem inflammatory syndrome in (MIS-C) emerged. We report on unique hematologic immunologic parameters that distinguish between COVID-19 MIS-C provide insight into pathophysiology.
We present a series of 6 critically ill children with multisystem inflammatory syndrome in children. Key findings this include fever, diarrhea, shock, and variable presence rash, conjunctivitis, extremity edema, mucous membrane changes.
Abstract Most children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have mild or minimal disease, a small proportion developing disease multisystem inflammatory in (MIS-C). Complement-mediated thrombotic microangiopathy (TMA) has been associated SARS-CoV-2 adults but not studied the pediatric population. We hypothesized that complement activation plays an important role and sought to understand if TMA was present these patients. enrolled 50 hospitalized...
Developing a SARS-CoV-2 Vaccine at Warp Speed The coronavirus disease 2019 (COVID-19) pandemic has unleashed major and substantial changes in the provision of health care, including public policy practice medicine, ways most individuals live their lives. 1Significant also have occurred vaccine development, with shortening usual 15-to 20-year timeline to one that might be as short 1 1.5 years. 2 COVID-19, acute illness due severe respiratory syndrome (SARS-CoV-2), was first reported Wuhan,...
Objectives: Multicenter data on the characteristics and outcomes of children hospitalized with coronavirus disease 2019 are limited. Our objective was to describe characteristics, ICU admissions, among using Society Critical Care Medicine Discovery Viral Infection Respiratory Illness Universal Study: Coronavirus Disease registry. Design: Retrospective study. Setting: Study (Coronavirus 2019) Patients: Children (< 18 yr) at participating hospitals from February 2020 January 2021....
There are no proven safe and effective therapies for children who develop life-threatening complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Convalescent plasma (CP) has demonstrated potential benefit in adults with SARS-CoV-2, but theoretical risks.We present the first report CP disease 2019 (COVID-19), providing data on four pediatric patients distress syndrome. We measured donor antibody levels recipient response prior to following infusion. Infusion was not...
Abstract Background The upper and lower respiratory tracts feature distinct environments responses affecting microbial colonization but investigating the relationship between them is technically challenging. We aimed to identify relationships taxa colonizing nasopharynx trachea across childhood. Methods employed V4 16S rRNA gene sequencing profile nasopharyngeal swabs tracheal aspirates collected from 172 subjects 20 weeks 18 years of age. These samples were prior elective procedures over...
Clinical practice guidelines are being developed for a number of topics in medicine to decrease variability and improve evidenced-based care. Within orthopaedic surgery, the American Academy Orthopaedic Surgeons (AAOS) has dedicated committee that produces these clinical on variety issues. One such issue was treatment pediatric diaphyseal femoral fractures, with guideline published 2009. We performed retrospective review fractures at single institution from 2007 2012 assess impact this...
Abstract Rash is a common feature of multisystem inflammatory syndrome in children (MIS-C), postinfectious hyperinflammatory disease associated with prior severe acute respiratory coronavirus 2 infection. Because the differential diagnosis fever and rash broad, understanding clinical characteristics MIS-C may assist diagnosis. Here we describe cutaneous findings observed series MIS-C-associated rash.
Background: In 2009, the American Academy of Orthopedic Surgeons published clinical practice guidelines (CPGs) on treatment pediatric diaphyseal femur fractures, which recommended a nonaccidental trauma (NAT) evaluation for all patients below 36 months age. A recent study these found <50% compliance with this recommendation. We aimed to identify areas improvement in guideline. Methods: retrospective review was performed presenting single tertiary care hospital fracture from January 2007...
A significant proportion of children with functional abdominal pain develop chronic pain. Identifying clinical characteristics predicting persistence is important in targeting interventions. We examined whether child anxiety and/or pain-stooling relations were related to maintenance frequency and compared the predictive value 3 methods for assessing (ie, diary, parent report, report).Seventy-six (7-10 years old at baseline) who presented medical treatment followed up 18 24 months later....
Abstract Multisystem Inflammatory Syndrome in Childhood (MIS-C) follows SARS-CoV-2 infection and frequently leads to intensive care unit admission. The inability rapidly discriminate MIS-C from similar febrile illnesses delays treatment misdiagnosis. To identify diagnostic discriminators at the time of emergency department presentation, we enrolled 104 children who met screening criteria, 14 whom were eventually diagnosed with MIS-C. Before treatment, collected breath samples for volatiles...
There are no proven safe and effective therapies for children who develop life-threatening complications of SARS-CoV-2. Convalescent plasma (CP) has demonstrated potential benefit in adults with SARS-CoV-2 but theoretical risks. We report on the first use CP COVID-19, providing data four pediatric patients acute respiratory distress syndrome. measured donor antibody levels recipient response prior to following infusion. Infusion was not associated antibody-dependent enhancement (ADE) did...
Blatz, Allison1; Rotta, Alexandre2; Wilson-Costello, Deanne2; Shein, Steven2 Author Information
Pradhan, Sarah1; Blatz, Allison1; Rotta, Alexandre1; Wilson-Costello, Deanne1; Shein, Steven1 Author Information
The upper (URT) and lower (LRT) respiratory tract feature distinct environments responses affecting microbial colonization but investigating the relationship between them is technically challenging. We aimed to identify relationships taxa colonizing URT LRT explore their with development during childhood.
Introduction: Hypo- and hyper-inflammatory phenotypes of adult pediatric ARDS have been identified with distinct response to treatment outcomes. However, the applicability these biologic other critical illnesses is not known. We hypothesize that hypo- outcomes would be using similar cytokines in children sepsis as previously reported ARDS. Methods: performed a secondary analysis 161 patients < 18 years treated for sepsis/septic shock at single academic children's hospital who were enrolled...
Purpose: Pediatric Intensive Care Unit (PICU) patients who require mechanical ventilation (MV) frequently receive neuropharmacologic agents like benzodiazepines, opioids, neuromuscular antagonists, and dexmedetomidine. The United States Food Drug Administration recently warned against the use of some in young children due to risk neurotoxicity. Our group reported increasing prescription many mechanically ventilated for bronchiolitis, a concurrent increase rehabilitative services. aim this...