A5108052564- Biomedical Ethics and Regulation
- Cancer Genomics and Diagnostics
- Ethics in Clinical Research
- SARS-CoV-2 and COVID-19 Research
- Physical Activity and Health
- Hospital Admissions and Outcomes
- Obesity, Physical Activity, Diet
- Food Allergy and Anaphylaxis Research
- Retinal Diseases and Treatments
- Diet and metabolism studies
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Pain Management and Placebo Effect
- Protein Degradation and Inhibitors
- COVID-19 Impact on Reproduction
- Electroconvulsive Therapy Studies
- Patient Dignity and Privacy
- Telemedicine and Telehealth Implementation
- Salivary Gland Tumors Diagnosis and Treatment
- Sarcoidosis and Beryllium Toxicity Research
- Hematopoietic Stem Cell Transplantation
- Glycogen Storage Diseases and Myoclonus
- Simulation-Based Education in Healthcare
- Health Promotion and Cardiovascular Prevention
- Occupational exposure and asthma
United States Department of State
2021-2025
National Center for Chronic Disease Prevention and Health Promotion
2025
Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR)
2024
Hope Foundation
2024
Stanford University
2016-2023
University of California, Los Angeles
2023
University of Illinois Chicago
2023
Cancer Research And Biostatistics
2023
Duke University Hospital
2023
Inovio Pharmaceuticals (United States)
2021-2022
Abstract Background Additional severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines that are safe and effective as primary boosters remain urgently needed to combat the disease 2019 (COVID-19) pandemic. We describe safety durability of immune responses following doses a homologous booster dose an investigational DNA vaccine (INO-4800) targeting full-length spike antigen. Methods Three dosage strengths INO-4800 (0.5 mg, 1.0 2.0 mg) were evaluated in 120 age-stratified healthy...
Aim To canvass the UK pathology community to ascertain current levels of digital usage in clinical and academic histopathology departments, prevalent attitudes pathology. Methods A 15-item survey was circulated National Health Service departments across using SurveyMonkey online tool. Responses were sought at a departmental or institutional level. Where possible, heads approached asked complete survey, forward it most relevant individual their department. Data collected over 6-month period...
Abstract The aim of this work was to explore whether real-world walking speed (RWS) would change as a consequence 60-day bed-rest. main hypothesis that daily RWS decrease after the bed-rest, with subsequent recovery during first days re-ambulation. Moreover, an exploratory analysis done in order understand there is agreement between loss bed-rest and maximum oxygen uptake capacity (VO 2max ), or maximal vertical jump power (JUMP) respectively. Twenty-four subjects were randomly assigned one...
Beverage industry marketing tactics can cause caregivers to misperceive sweetened fruit drinks (SFDs) as healthy, increasing the likelihood they give their children SFDs. The Sweet Lies! countermarketing campaign sought educate Hawai'i of ages 0-8 about industry's misleading and harms Focus groups were held develop messages for caregivers. ran January-April 2023 on television, digital social media, radio, in malls. Campaign effects assessed with media metrics pre-/post-campaign...
While pathologists have always played a pivotal role in clinical trials ensuring accurate diagnosis and staging, pathology data from prognostic predictive tests are increasingly being used to enrol, stratify randomise patients experimental treatments. The use of pathological parameters as primary secondary outcome measures, either standalone classifiers or combination with data, is also becoming more common. Moreover, reporting estimates residual disease, termed 'pathological complete...
Abstract Estuaries are highly productive ecosystems where sediment microbes mediate carbon and nutrient cycling. Our understanding of estuarine microbial communities is limited by a lack system level characterizations. Here we obtained 639 novel metagenome-assembled genomes (MAGs) from four seasons across San Francisco Bay (SFB), the largest estuary on West Coast United States. In shallow sediments, observed broad diversity uncultured prokaryotes with distinct pathways for nitrogen sulfur...
Clinical trials rely on multidisciplinary teams for successful delivery. Pathologists should be involved in clinical trial design from the outset to ensure that protocols are optimised deliver maximum data collection and translational research opportunities. must performed according principles of Good Practice (GCP) sponsor has an obligation all personnel have undergone training relevant their role. who delivery often required undergo formal GCP may additionally Laboratory if they laboratory...
Understanding how painful hypersensitive states develop and persist beyond the initial hours to days is critically important in effort devise strategies prevent and/or reverse chronic states. Changes nociceptor transcription can alter abundance of nociceptive signaling elements, resulting longer-term change phenotype. As a result, sensitized be further amplified nocifensive behaviors sustained for weeks months. Building on our previous finding that factor Sp4 positively regulates expression...
ABSTRACT Inhibition of amyloid precursor protein (APP) beta-site cleaving enzyme 1 (BACE1; BACE) has been a target for Alzheimer’s disease (AD) therapeutic development, but impaired by off-target effects clinically evaluated inhibitors, including inhibition cleavage non-APP substrates. Here, we report our identification BACE inhibitors series that are not only selective the APP substrate, also BACE1 as targeted enzyme. These APP-selective fluoro aminohydantoin (FAH) inhibitor compounds were...
Abstract Introduction Decisions to disclose HIV serostatus may be complicated by internalised stigma. We evaluated the association of stigma in biological mothers living with disclosure their children perinatally HIV‐exposed but uninfected (CHEU). Methods Mothers and CHEU were enrolled United States (U.S.)‐based Surveillance Monitoring for Antiretroviral Therapy (ART) Toxicities (SMARTT) study Pediatric HIV/AIDS Cohort Study (PHACS), a longitudinal outcomes related utero exposure ART among...
BACKGROUND AND OBJECTIVE: To describe the use of a navigated laser system for treatment retinal tears. MATERIALS METHODS: A planned pattern retinopexy was performed using photocoagulator incorporating rapid panretinal photocoagulation technology with an individualized target overlay to produce 3 × square surrounding horseshoe tear. Institutional review board approval not applicable this case. RESULTS: Successful 360° around tear achieved. CONCLUSION: In select cases, may be utilized [...
Objective Academic pathology is facing a crisis; an ongoing decline in academic posts, paucity of pathologist’s in-training and unfilled posts at time when cellular departments are challenged to deliver increasing numbers molecular tests. The National Cancer Research Institute initiative Cellular & Molecular Pathology commissioned survey assess attitudes consultants towards research order understand barriers identify possible solutions improve this situation. As encompassing number...
Background: Additional SARS-CoV-2 vaccines that are safe and effective as primary boosters remain urgently needed to combat the COVID-19 pandemic. We describe safety durability of immune responses following two doses a homologous booster dose an investigational DNA vaccine (INO-4800) targeting full-length spike antigen. Methods: Three dosage strengths INO-4800 (0.5 mg, 1.0 2.0 mg) were evaluated in 120 age-stratified healthy adults. Intradermal injection followed by electroporation at 0 4...
Palliative Extended and Care at Home (PEACH) is a rapid response nurse-led package of care mobilized for palliative patients who have an expressed preference to die home. This study aimed identify the demographic clinical predictors home death receiving package. Deidentified data were used from administrative information systems. Univariate multivariate analyses conducted assess association sociodemographic factors with mode separation. Furthermore, 1754 clients received PEACH during period....
<ns4:p>The input of pathologists is essential for the conduct many forms research, including clinical trials. As custodians patient samples, pathology departments have a duty to ensure compliance with relevant regulations, standards and guidelines ethical effective use their intended investigational analysis, when patients are participating in research study. The results studies impacts beyond study itself as they may inform changes policy practice or support licensing medicines devices....
The input of pathologists is essential for the conduct many forms research, including clinical trials. As custodians patient samples, pathology departments have a duty to ensure compliance with relevant regulations, standards and guidelines ethical effective use their intended investigational analysis. This includes where patients are participating in research study. results studies impacts beyond study itself as they may inform changes policy practice or support licensing medicines devices....
There are no proven safe and effective therapies for children who develop life-threatening complications of SARS-CoV-2. Convalescent plasma (CP) has demonstrated potential benefit in adults with SARS-CoV-2 but theoretical risks. We report on the first use CP COVID-19, providing data four pediatric patients acute respiratory distress syndrome. measured donor antibody levels recipient response prior to following infusion. Infusion was not associated antibody-dependent enhancement (ADE) did...