A5087489552- Reproductive Physiology in Livestock
- Endometriosis Research and Treatment
- Peroxisome Proliferator-Activated Receptors
- Reproductive System and Pregnancy
- SARS-CoV-2 and COVID-19 Research
- Estrogen and related hormone effects
- Uterine Myomas and Treatments
- Milk Quality and Mastitis in Dairy Cows
- SARS-CoV-2 detection and testing
- Reproductive Biology and Fertility
- Genetic and phenotypic traits in livestock
- Pluripotent Stem Cells Research
- Retinoids in leukemia and cellular processes
- Growth Hormone and Insulin-like Growth Factors
- Vaccine Coverage and Hesitancy
- Mesenchymal stem cell research
- Ruminant Nutrition and Digestive Physiology
- COVID-19 Clinical Research Studies
- Meat and Animal Product Quality
- Endometrial and Cervical Cancer Treatments
- Connexins and lens biology
- Inflammatory mediators and NSAID effects
Inovio Pharmaceuticals (United States)
2021-2022
Institute of Animal Reproduction and Food Research
2014-2019
Polish Academy of Sciences
2013-2019
Abstract Background Additional severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines that are safe and effective as primary boosters remain urgently needed to combat the disease 2019 (COVID-19) pandemic. We describe safety durability of immune responses following doses a homologous booster dose an investigational DNA vaccine (INO-4800) targeting full-length spike antigen. Methods Three dosage strengths INO-4800 (0.5 mg, 1.0 2.0 mg) were evaluated in 120 age-stratified healthy...
The aim of this study was to identify uterine pluripotent cells both in bovine tissues as well epithelial, stromal, and myometrial cell populations. Moreover, the relationship markers expression with age horn side considered. Uterine tissue collected from ipsilateral contralateral horns (days 8-10 estrous cycle). Immunohistostaining for C-KIT, OCT3/4, NANOG, SOX2 determined. mRNA NANOG evaluated relative cow side. Gene protein these luminal by real-time PCR western blotting respectively....
Adenomyosis is a proliferative uterine dysfunction with unknown aetiology. One possible mechanism of its development involves disturbances in stem cell differentiation tissue. Previously, we identified pluripotent/multipotent cells the bovine uterus, therefore our present study focused on determining expression pluripotency markers, NANOG, OCT4 and SOX2, adenomyotic tissues cells. Immunolocalisation revealed protein SOX2 both normal uteri. mRNA for NANOG was increased obtained from uteri...
We have previously shown the influence of leukotrienes (LTs) on reproductive functions in vivo: LTB4 is luteotrophic and supports corpus luteum function inducing PGE2 progesterone (P4) secretion, whereas LTC4 luteolytic stimulates PGF2α secretion cattle. The aim this study was to examine expression production profiles LTs their actions endometrium. LT receptors (LTB4R for CysLTR2 LTC4), 5-lipoxygenase (LO), 12-LO synthase (LTCS) LTA4 hydrolase (LTAH) mRNA protein expression, as well were...
Abstract Background Adenomyosis is a uterine dysfunction defined as the presence of endometrial glands within myometrium. There evidence that proangiogenic factors may play role during development adenomyosis; however, exact mechanism remains unknown. The aim study was to determine action vascular endothelial growth factor A (VEGFA) in tissue and cells adenomyosis. Results Uterine tissues were collected examined for extent Gene protein expression VEGFA its two receptors (VEGFR1 VEGFR2)...
Abstract Adenomyosis is defined as the presence of glandular foci external to endometrium uterus, either in myometrium or/and perimetrium, depending on progress this dysfunction. To date, we showed that steroids secretion and prolactin expression proliferative processes are disturbed during uterine adenomyosis cows. During endometriosis eutopic women, gap junctions down regulated. The transmembrane junction protein, connexin (Cx43) necessary for endometrial morphological, biochemical...
Background: Additional SARS-CoV-2 vaccines that are safe and effective as primary boosters remain urgently needed to combat the COVID-19 pandemic. We describe safety durability of immune responses following two doses a homologous booster dose an investigational DNA vaccine (INO-4800) targeting full-length spike antigen. Methods: Three dosage strengths INO-4800 (0.5 mg, 1.0 2.0 mg) were evaluated in 120 age-stratified healthy adults. Intradermal injection followed by electroporation at 0 4...