A5011478803- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Polyomavirus and related diseases
- Cancer-related gene regulation
- Lymphoma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Global Cancer Incidence and Screening
- CAR-T cell therapy research
- Protein Degradation and Inhibitors
- Childhood Cancer Survivors' Quality of Life
- Economic and Financial Impacts of Cancer
- Palliative Care and End-of-Life Issues
- Diverse Approaches in Healthcare and Education Studies
- Transplantation: Methods and Outcomes
- Healthcare Policy and Management
- Technology and Data Analysis
- Parvovirus B19 Infection Studies
The Ohio State University
2022-2025
Nationwide Children's Hospital
2022-2025
Albert Einstein College of Medicine
2012
ABSTRACT Epstein–Barr virus (EBV)‐positive smooth muscle tumors (SMTs) are rare seen in immunocompromised patients. There is no clear standard of care for the management and treatment EBV‐SMTs. Patients often treated with chemotherapy, surgery, and/or radiation. Additional options include antiretroviral treatment, reduction immunosuppression, EBV‐directed virus‐specific T cells (VSTs). This report describes regimens outcomes eight patients EBV‐associated SMTs. Although consensus EBV‐SMTs has...
Purpose: Primary central nervous system posttransplant lymphoproliferative disorder (PCNS-PTLD) is a complication of solid organ transplantation with poor prognosis and typically associated Epstein-Barr virus (EBV). We hypothesized EBV lytic-phase protein expression would allow successful treatment antiviral therapy.Patients Methods: Thirteen patients were treated zidovudine (AZT), ganciclovir (GCV), dexamethasone, rituximab in EBV+ PCNS-PTLD. Twice-daily, intravenous AZT 1,500 mg, GCV 5...
Mantle cell lymphoma (MCL) is an incurable B-cell non-Hodgkin lymphoma, and patients who relapse on targeted therapies have poor prognosis. Protein arginine methyltransferase 5 (PRMT5), enzyme essential for transformation, drives multiple oncogenic pathways overexpressed in MCL. Despite the antitumor activity of PRMT5 inhibition (PRT-382/PRT-808), drug resistance was observed a patient-derived xenograft (PDX) MCL model. Decreased survival mice engrafted with these inhibitor-resistant cells...
Abstract Introduction: Epstein-Barr virus positive (EBV+) central nervous system lymphoproliferative diseases (CNS-LPD) are aggressive clinical conditions with poor prognosis. We have previously reported use of a ganciclovir (GCV), zidovudine (AZT), rituximab and dexamethasone regimen (GARD) that induced complete durable responses in patients primary CNS post-transplant disease (PTLD). Responses were associated detection two GCV/AZT viral drug targets, the EBV protein kinases BGLF4 BXLF1....
Epstein-Barr virus (EBV)-associated central nervous system lymphoproliferative diseases (CNSL) are aggressive clinical conditions with poor prognosis. We have reported that durable responses in patients primary CNS post-transplant disease (PTLD) were associated detection of two ganciclovir (GCV)/zidovudine (AZT) viral drug target proteins, the EBV kinases BGLF4 and BXLF1 CNSL biopsies. These lytic mechanism for expression latently infected EBV+ has been unknown. By carrying out RNA analysis...
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<p>Dosing schedule figure Dose reduction table</p>
<div>Abstract<p><b>Purpose:</b> Primary central nervous system posttransplant lymphoproliferative disorder (PCNS-PTLD) is a complication of solid organ transplantation with poor prognosis and typically associated Epstein–Barr virus (EBV). We hypothesized EBV lytic-phase protein expression would allow successful treatment antiviral therapy.</p><p><b>Patients Methods:</b> Thirteen patients were treated zidovudine (AZT), ganciclovir (GCV),...
<div>Abstract<p><b>Purpose:</b> Primary central nervous system posttransplant lymphoproliferative disorder (PCNS-PTLD) is a complication of solid organ transplantation with poor prognosis and typically associated Epstein–Barr virus (EBV). We hypothesized EBV lytic-phase protein expression would allow successful treatment antiviral therapy.</p><p><b>Patients Methods:</b> Thirteen patients were treated zidovudine (AZT), ganciclovir (GCV),...