A5061933807- Cancer-related gene regulation
- Lymphoma Diagnosis and Treatment
- Protein Degradation and Inhibitors
- CAR-T cell therapy research
- RNA modifications and cancer
- Adolescent and Pediatric Healthcare
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders Research
- DNA Repair Mechanisms
The Ohio State University
2022-2025
Hemophagocytic lymphohistiocytosis (HLH) is a rare but aggressive and potentially lethal hyperinflammatory syndrome characterized by pathologic immune activation excessive production of proinflammatory cytokines leading to tissue damage multisystem organ failure. There an urgent need for the discovery novel targets development therapeutic strategies treat this deadly syndrome. Protein Arginine Methyltransferase 5 (PRMT5) mediates T cell-based inflammatory responses, making it potential...
Mantle cell lymphoma (MCL) is an incurable B-cell characterized by significant genomic instability. MCL patients who progress on targeted therapies have a short survival; thus, novel therapeutic strategies are urgently needed. Overexpression of transducin β-like protein 1 X-linked (TBL1X) has been documented in several types cancer and associated with poor prognosis. TBL1X critical regulator multiple oncogenic networks; however, its function not explored. Our data show that, unlike normal B...
Mantle cell lymphoma (MCL) is an incurable B-cell non-Hodgkin lymphoma, and patients who relapse on targeted therapies have poor prognosis. Protein arginine methyltransferase 5 (PRMT5), enzyme essential for transformation, drives multiple oncogenic pathways overexpressed in MCL. Despite the antitumor activity of PRMT5 inhibition (PRT-382/PRT-808), drug resistance was observed a patient-derived xenograft (PDX) MCL model. Decreased survival mice engrafted with these inhibitor-resistant cells...