A5043972835- Genetic and Kidney Cyst Diseases
- Single-cell and spatial transcriptomics
- Developmental Biology and Gene Regulation
- Immune Cell Function and Interaction
- Renal and related cancers
- Neurogenesis and neuroplasticity mechanisms
- Viral-associated cancers and disorders
- Protist diversity and phylogeny
- Cancer-related gene regulation
- CAR-T cell therapy research
- Hedgehog Signaling Pathway Studies
- Cytomegalovirus and herpesvirus research
- Pain Management and Treatment
- Laser Applications in Dentistry and Medicine
- Epigenetics and DNA Methylation
- Adolescent and Pediatric Healthcare
- Autoimmune and Inflammatory Disorders Research
- Carcinogens and Genotoxicity Assessment
- Energy Harvesting in Wireless Networks
- Wnt/β-catenin signaling in development and cancer
- Lymphoma Diagnosis and Treatment
- Glutathione Transferases and Polymorphisms
- Toxic Organic Pollutants Impact
- Transcranial Magnetic Stimulation Studies
- Color perception and design
Howard Hughes Medical Institute
2012-2025
The Ohio State University
2018-2025
Kettering University
2024-2025
North Carolina State University
2024-2025
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2018-2023
The University of Texas at Austin
2013-2015
Institute of Molecular and Cell Biology
2012
Institut de Biologie Moléculaire et Cellulaire
2012
National Institute for Occupational Safety and Health
2006
Oregon State University
2006
The mechanisms linking systems-level programs of gene expression to discrete cell biological processes in vivo remain poorly understood. In this study, we have defined such a program for multi-ciliated epithelial cells (MCCs), type critical proper development and homeostasis the airway, brain reproductive tracts. Starting from genomic analysis cilia-associated transcription factor Rfx2, used bioinformatics approaches gain insights into molecular basis cilia assembly function. Moreover,...
Cilia play key roles in development and homeostasis, defects cilia structure or function lead to an array of human diseases. Ciliogenesis is accomplished by the intraflagellar transport (IFT) system, a set proteins governing bidirectional cargoes within ciliary axonemes. In this paper, we present novel platform for vivo analysis vertebrate IFT dynamics. Using platform, show that planar cell polarity (PCP) effector Fuz was required normal dynamics cilia, first evidence directly linking PCP...
Hemophagocytic lymphohistiocytosis (HLH) is a rare but aggressive and potentially lethal hyperinflammatory syndrome characterized by pathologic immune activation excessive production of proinflammatory cytokines leading to tissue damage multisystem organ failure. There an urgent need for the discovery novel targets development therapeutic strategies treat this deadly syndrome. Protein Arginine Methyltransferase 5 (PRMT5) mediates T cell-based inflammatory responses, making it potential...
The formation of the mammalian brain requires regionalization and morphogenesis cranial neural plate, which transforms from an epithelial sheet into a closed tube that provides structural foundation for patterning circuit formation. Sonic hedgehog (SHH) signaling is important plate closure, but transcriptional changes give rise to spatially regulated cell fates behaviors build have not been systematically analyzed. Here we used single-cell RNA sequencing generate atlas gene expression at six...
The formation of the mammalian brain requires regionalization and morphogenesis cranial neural plate, which transforms from an epithelial sheet into a closed tube that provides structural foundation for patterning circuit formation. Sonic hedgehog (SHH) signaling is important plate closure, but transcriptional changes give rise to spatially regulated cell fates behaviors build have not been systematically analyzed. Here, we used single-cell RNA sequencing generate atlas gene expression at...
Abstract Introduction: Epstein-Barr Virus (EBV) is an oncogenic herpesvirus linked to hematologic malignancies. EBV enters latency within host cells and can undergo lytic activation, resulting in release of infectious virions. Latent mediates malignant transformation, while a frequent complication immune suppression settings like post-transplant lymphoproliferative disease (PTLD). Current clinical assays detect only the presence via qPCR, limiting their diagnostic use. DNA methylation on...
Neural tube closure defects are a major cause of infant mortality, with exencephaly accounting for nearly one-third cases. However, the mechanisms cranial neural not well understood. Here, we show that this process involves tissue-wide pattern apical constriction controlled by Sonic hedgehog (Shh) signaling. Midline cells in mouse midbrain neuroepithelium flat large surfaces, whereas lateral taller and undergo synchronous constriction, driving fold elevation. Embryos lacking Shh effector...
Abstract A complex mixture of polycyclic aromatic hydrocarbons (PAH) extracted from coal tar, the Standard Reference Material (SRM) 1597, was recently shown to decrease levels DNA binding 2 strong carcinogens benzo[ a ]pyrene (BP) and dibenzo[ , l (DBP) in human mammary carcinoma‐derived cell line MCF‐7 (Mahadevan et al. Chem Res Toxicol 2005;18:224–231). The present study designed further elucidate biochemical mechanisms involved this inhibition process. We examined effects SRM 1597 on...
Cilia are small, microtubule-based protrusions important for development and homeostasis. We recently demonstrated that the planar cell polarity effector protein Fuz is a critical regulator of axonemal intraflagellar transport dynamics localization. Here, we report our findings on role small GTPase Rsg1, known binding partner Fuz, its in cytoplasmic localization proteins.We find Rsg1 loss function leads to impaired IFT multiciliated cells. further show required appropriate retrograde IFT-A...
Epstein-Barr virus (EBV) is a ubiquitous herpes associated with various cancers. EBV establishes latency life-long persistence in memory B-cells and can reactivate lytic infection placing immunocompromised individuals at risk for EBV-driven lymphoproliferative disorders (EBV-LPD). Despite the ubiquity of EBV, only small percentage patients (~20%) develop EBV-LPD. Engraftment immunodeficient mice peripheral blood mononuclear cells (PBMCs) from healthy EBV-seropositive donors leads to...
The formation of the mammalian brain requires regionalization and morphogenesis cranial neural plate, which transforms from an epithelial sheet into a closed tube that provides structural foundation for patterning circuit formation. Sonic hedgehog (SHH) signaling is important plate closure, but transcriptional changes give rise to spatially regulated cell fates behaviors build have not been systematically analyzed. Here we used single-cell RNA sequencing generate atlas gene expression at six...
Epstein-Barr virus (EBV) is a human herpes that infects over 90% of the world's population and linked to development cancer. In immune-competent individuals, EBV infection mitigated by highly efficient virus-specific memory T-cell response. Risk EBV-driven cancers increases with immune suppression (IS). EBV-seronegative recipients solid organ transplants are at high risk developing post-transplant lymphoproliferative disease (PTLD) due iatrogenic IS. While reducing level IS may improve...
The formation of the mammalian brain requires regionalization and morphogenesis cranial neural plate, which transforms from an epithelial sheet into a closed tube that provides structural foundation for patterning circuit formation. Sonic hedgehog (SHH) signaling is important plate closure, but transcriptional changes give rise to spatially regulated cell fates behaviors build have not been systematically analyzed. Here we used single-cell RNA sequencing generate atlas gene expression at six...
The formation of the mammalian brain requires regionalization and morphogenesis cranial neural plate, which transforms from an epithelial sheet into a closed tube that provides structural foundation for patterning circuit formation. Sonic hedgehog (SHH) signaling is important plate closure, but transcriptional changes give rise to spatially regulated cell fates behaviors build have not been systematically analyzed. Here we used single-cell RNA sequencing generate atlas gene expression at six...