A5030541223- Refrigeration and Air Conditioning Technologies
- Building Energy and Comfort Optimization
- Adsorption and Cooling Systems
- Heat Transfer and Optimization
- Diabetes Management and Research
- Advanced Control Systems Optimization
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pharmacology and Obesity Treatment
- Air Quality Monitoring and Forecasting
- Lipoproteins and Cardiovascular Health
- Advanced machining processes and optimization
- Scheduling and Optimization Algorithms
- Thermodynamic and Exergetic Analyses of Power and Cooling Systems
- Advanced Manufacturing and Logistics Optimization
- Injection Molding Process and Properties
- Ferroptosis and cancer prognosis
- Traffic Prediction and Management Techniques
- Cancer, Lipids, and Metabolism
- Air Quality and Health Impacts
- Pharmacogenetics and Drug Metabolism
- Dielectric materials and actuators
- Multiple Myeloma Research and Treatments
- Nanofabrication and Lithography Techniques
- Solar-Powered Water Purification Methods
- High voltage insulation and dielectric phenomena
Qingdao University of Science and Technology
2016-2025
Academy of Military Medical Sciences
2024
Czech Academy of Sciences, Institute of Microbiology
2024
Shenzhen Technology University
2024
Jinan University
2023
Wuhan University
2017-2022
First Affiliated Hospital Zhejiang University
2022
Zhongnan Hospital of Wuhan University
2017-2020
Bristol-Myers Squibb (United States)
2008-2020
Xi'an Medical University
2020
With the detailed load data provided by smart meter, learning of electricity usage behavior for individual household short-term forecasting has become a hot research topic. The existing methods generally ignore relation among multiple households and fail to obtain enough information from limited data, resulting in accuracy reduction. To solve this problem, novel hybrid <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Multitask...
Microinjection molding (µIM) is considered to be one of the most flexible, reliable and cost effective manufacturing routes form plastic micro-components for microsystems. The machine, mold tool fabrication, material selection process controlling in this specific field have been greatly developed over past decades. This review aims present new trends towards improving micro-component performance by reviewing latest developments area considering potential directions. key concerns product...
Objective: To identify candidate biomarkers correlated with clinical prognosis of patients bladder cancer (BC). Methods: Weighted gene co-expression network analysis was applied to build a hub genes tumor node metastasis (TNM) staging BC patients. Functional enrichment conducted functionally annotate the genes. Protein-protein interaction performed interactions among Survival analyses were characterize role on survival Gene set find potential mechanisms involved in proliferation promoted by...
Indoor temperature prediction of multiple zones in near future horizons is vital developing an optimal regulation strategy heating, ventilation, and air conditioning systems large-scale complex buildings. This is, however, challenging due to the spatial–temporal correlation multivariable coupling characteristics. article proposes a novel deep learning framework incorporating distributed long short-term memory graph convolution network namely DL-GCN for indoor large public buildings, aiming...
Objective To investigate the effect of individualized exercise on capacity and health-related quality life (HRQoL) in uraemic patients during maintenance haemodialysis (MHD). Methods Patients receiving MHD were divided randomly into a test group, who underwent recumbent cycling dialysis, control performed simple stretching exercises. The same dialysis protocol was used for all study participants. At start after 12 weeks, measured using tests physical ability; HRQoL kidney disease score...
Highlights•Tocilizumab therapy can reduce the fatality for severe SFTS patients.•A combined of tocilizumab plus corticosteroids was recommended SFTS.•Patients treated with did not experience more serious coinfections.SummaryBackgroundSevere fever thrombocytopenia syndrome (SFTS) is an emerging viral hemorrhagic high rates. The blockade pro-inflammatory cytokines presents a promising therapeutic strategy.MethodsWe conducted randomized clinical trial at 154th hospital, Xinyang, Henan Province....
Abstract Objectives Adamantinomatous craniopharyngiomas (adaCP) accounts for 5.6% to 15% of intracranial tumors. High expression chemokine (C‐X‐C motif) ligand 12 (CXCL12, also known as stromal cell‐derived factor 1 [SDF1]) and its receptor CXC type 4 (CXCR4) are widespread in various malignancy via multiple signal transduction pathways. This study aims investigate the mechanism CXCL12/CXCR4 promoting proliferation, migration, invasion adaCP. Methods Quantitative real‐time polymerase chain...
3-Hydroxy-3-methylglutaryl coenzyme-A reductase (HMGR) inhibitors, more commonly known as statins, represent the gold standard in treating hypercholesterolemia. Although statins are regarded generally safe, they to cause myopathy and, rare cases, rhabdomyolysis. Statin-dependent effects on plasma lipids mediated through inhibition of HMGR hepatocyte, whereas evidence suggests that myotoxicity is due within myocyte. Thus, an inhibitor with increased selectivity for hepatocytes could...
Statins, because of their excellent efficacy and manageable safety profile, represent a key component in the current armamentarium for treatment hypercholesterolemia. Nonetheless, myopathy remains concern this important drug class. Cerivastatin was withdrawn from market myotoxicity concerns. BMS-423526 [{(3<i>R</i>,5<i>S</i>)-7-[4-(4-fluorophenyl)-6,7-dihydro-2-(1-methylethyl)-5<i>H</i>-benzo[6,7]cyclohepta[1,2-<i>b</i>]pyridin-3-yl]-3,5-dihydroxy-heptenoic acid} sodium salt], similar to...
A series of diphenylpyridylethanamine (DPPE) derivatives was identified exhibiting potent CETP inhibition. Replacing the labile ester functionality in initial lead 7 generated a amides and ureas. Further optimization DPPE for potency resulted discovery cyclopentylurea 15d, which demonstrated reduction cholesterol transfer activity (48% predose level) hCETP/apoB-100 dual transgenic mice. The PK profile 15d suboptimal, further N-terminus amide 20 with an improved robust efficacy mice hamsters....
Background: Multiple myeloma (MM) is one of the most common types hematological malignance, and prognosis MM patients remains poor. Objective: To identify validate a genetic prognostic signature in with MM. Methods: Co-expression network was constructed to hub genes related International Staging System (ISS) stage Functional analysis conducted. Univariate Cox proportional hazard regression conducted correlated overall survival (OS) patients. Least absolute shrinkage selection operator...