A5051141079- Angiogenesis and VEGF in Cancer
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Thyroid Cancer Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Immunotherapy and Immune Responses
- Thyroid and Parathyroid Surgery
- Circular RNAs in diseases
- Biomarkers in Disease Mechanisms
- CRISPR and Genetic Engineering
- Advanced biosensing and bioanalysis techniques
- Congenital heart defects research
- Ubiquitin and proteasome pathways
- RNA and protein synthesis mechanisms
- Bioactive Compounds and Antitumor Agents
- Head and Neck Anomalies
- Cancer-related Molecular Pathways
- Genital Health and Disease
- Clusterin in disease pathology
- Lymphatic Disorders and Treatments
- Kruppel-like factors research
Tianjin Medical University Cancer Institute and Hospital
2015-2024
Brigham and Women's Hospital
2024
Tianjin Medical University
2012-2019
Center for Cancer Research
2019
Hypoxia induced by antiangiogenic agents is linked to the generation of cancer stem cells (CSCs) and treatment failure through unknown mechanisms. The endothelial cell-independent microcirculation in malignant tumors defined as tumor cell vasculogenic mimicry (VM). In present study, we analyzed effects an agent on VM triple-negative breast (TNBC). Microcirculation patterns were detected patients with TNBC non-TNBC. Tientsin Albino 2 (TA2) mice engrafted mouse nude human lines or non-TNBC...
Background The aim of this study was to investigate the clinical significances and prognostic value CD133 CD44 (markers cancer stem-like cells, CSCs), vasculogenic mimicry (VM) in renal cell carcinoma (RCC). Methods Immunohistochemistry performed detect expression VM 110 RCC patients proven exhibit de novo metastases after radical nephrectomy. Results In RCC, positive rates 27.3%, 20.9%, 21.8% were obtained for CD44, CD133, VM, respectively. significantly associated with tumor size, grade,...
Abstract Vasculogenic mimicry ( VM ) refers to the unique capability of aggressive tumour cells mimic pattern embryonic vasculogenic networks. Epithelial–mesenchymal transition EMT regulator slug have been implicated in invasion and metastasis human hepatocellular carcinoma HCC ). However, relationship between formation is not clear. In study, we demonstrated that expression was associated with cancer stem cell (CSCs) phenotype patients. Importantly, showed statistically correlation...
Abstract Vasculogenic mimicry (VM) refers to the condition in which tumour cells mimic endothelial form extracellular matrix‐rich tubular channels. VM is more extensive aggressive tumours. The human epidermal growth factor receptor 2 (HER2) gene amplified 20–30% of breast cancers and has been implicated mediating metastasis. However, thus far, there have no data on role HER2 formation. Immunohistochemical histochemical double‐staining methods were performed display cancer specimens....
Arsenic trioxide (ATO) is a classic apoptosis-inducing agent used to treat acute promyelocytic leukemia. However, the therapeutic effect of ATO limited in lymphoma, which resists apoptosis possibly due inappropriate activation STAT3. Therefore, combination and STAT3 inhibitor may be potential strategy lymphoma. Dramatically, Cucurbitacin B (CuB), an effective component dichloromethane extraction from Trichosanthes kirilowii Maxim, synergistically eliminated resistance Burkitt’s lymphoma...
Cancer stem cells (CSCs) have been identified in various malignancies, and different properties examined to characterize CSCs: tumorigenicity immunocompromised mice, cell surface markers, label-retaining properties, proliferation as nonadherent spheres. This study explored the consistency efficiency among these methods. Among melanoma lines (A375, A875, MUM-2b, MUM-2c), only A375 MUM-2c grew spheres continuously propagated a defined serum-free medium vitro. Flow cytometry immunofluorescence...
DNA methylation is a kind of crucial epigenetic marker orchestrating gene expression, molecular function, and cellular phenotype. However, manipulating the status specific genes remains challenging. Here, clustered regularly interspaced palindromic repeats-Cas9-based near-infrared upconversion-activated editing system (CNAMS) was designed for optogenetic methylation. The fusion proteins photosensitive CRY2PHR, catalytic domain DNMT3A or TET1, CIBN catalytically inactive Cas9 (dCas9) were...
NUCB2, a novel multifunctional protein containing several functional domains, was newly found to play important roles in many cancers, but its role papillary thyroid cancer (PTC) is not well investigated. Therefore, our study performed explore the functions of NUCB2 PTC.NUCB2 level analyzed by immunohistochemistry. Data analyses were made performing chi-squared test. Quantitative reverse-transcription PCR, Western blot, colony formation, MTT, and transwell invasion assays test expression...
Triple-negative breast cancer, which is negative for the estrogen receptor, progesterone and human epidermal growth factor receptor 2, represents about 15–26% of all cancer cases. However, because its genotype, a triple-negative disease accounts remarkable metastasis mortality. Moreover, no targeted treatment available molecular mechanism initiation still unclear. Secreted clusterin (sCLU) associated with refractory to anti-estrogen in cells. We investigated sCLU expression 384 cases,...
MicroRNAs (miRNAs/miRs) are small non-coding RNAs identified in plants, animals and certain viruses; they function RNA silencing post-transcriptional regulation of gene expression. miRNAs also serve an important role the pathogenesis, diagnosis treatment tumors. However, few studies have investigated thyroid In present study, expression miRNA mRNA was compared between follicular carcinoma (FTC) adenoma (FA) samples, then miRNA-mRNA regulatory network analysis performed. Microarray datasets...
Thyroid cancer is the most common endocrine malignant tumor. The accurate risk stratification and prognosis assessment particularly important for patients with thyroid cancer, which can reduce tumor recurrence rate, morbidity, mortality effectively. DNA methylation one of widely studied epigenetic modifications. Many studies have shown that 5hmC-mediated demethylation played an role in tumors. hydroxylation 5mC catalyzed by ten-eleven translocation dioxygenase (TET). In this study, we first...
Physiological vasculogenesis in embryonic tissues share some important features with pathological neoangiogenesis tumors. Linearly Patterned Programmed Cell Necrosis (LPPCN) and Vasculogenic Mimicry (VM) have been reported The term VM refers to the aggressive tumor cells CD31-negative phenotype form Periodic Αcid Schiff (PAS)-positive network, that mimics pattern of vasculogenic networks. LPPCN had observed our laboratory, served as a spatial infrastructure for endothelium-dependent vessel...
Abstract Background Medullary thyroid cancer (MTC) has more aggressive behavior and poor prognosis. Ultrasound (US) facilitated the qualitative diagnosis of nodules, however, some MTC may be diagnosed as a benign nodule on ultrasound because features malignancy are lacking. The aim study was to investigate association between biological MTC. Methods findings medical records patients with Jan 2015 Jun 2017 were retrospectively reviewed at Tianjin Medical University Cancer Institute Hospital....
Malignant rhabdoid tumors (MRTs) are rare, lethal, pediatric predominantly found in the kidney, brain and soft tissues. MRTs driven by loss of tumor suppressor SNF5/INI1/SMARCB1/BAF47. The prognosis MRT is poor using currently available treatments, so new treatment targets need to be identified expand options for patients experiencing chemotherapy resistance. growth hormone insulin-like factor 2 (IGF2) signaling pathway a promising target overcome drug resistance many cancers. Here, we...
CpG island methylator phenotype (CIMP), characterized by the concurrent and widespread hypermethylation of a cluster CpGs, has been reported to play an important role in carcinogenesis. Limited studies have explored CIMP papillary thyroid carcinomas (PTCs). Here, genome-wide DNA methylation analysis 350 primary PTCs from Cancer Genome Atlas database that were assessed using Illumina HumanMethylation450K platform, our study helps identify two subtypes displayed markedly distinct levels,...
The linkage between IDO2 expression and cancer progression is still unclear, particularly in medullary thyroid carcinoma (MTC). Our purpose to unveil the potential correlations status, clinical-pathological parameters, patients' prognosis, possible immunomodulatory functions MTC.Immunohistochemical levels of were evaluated resected MTC surgical specimens corresponding lymph nodes. CD4 + T cell infiltration was also by immunohistochemical analysis tissues. association level with...
Gene therapy has been adapted for improving malignant tumor treatment. However, pharmacotherapies targeting cancer remain limited and are generally inapplicable rare disease patients. Oleanolic acid (OA) is a plant-derived triterpenoid that frequently used in Chinese medicine as safe but slow-acting treatment many disorders. Here, the congruent pharmacological activities of OA CRISPR-dCas9 AURKA or KDM1A disease-specific prognosis synthetic-biology-inspired design principle to engineer...
Abstract Tissue stem cells often exhibit developmental stage-specific and sexually dimorphic properties, but the underlying mechanism remains largely elusive. By characterizing IGF1R signaling in hematopoietic cells, here we report that its disruption exerts sex-specific effects adult progenitor (HSPCs). Loss of decreases HSPC population females not males, part due to a reduction proliferation induced by estrogen. In addition, female microenvironment enhances engraftment wild-type Igf1r...