A5058225466- Traditional Chinese Medicine Studies
- Fibroblast Growth Factor Research
- Cancer Cells and Metastasis
- Traditional Chinese Medicine Analysis
- Cancer Research and Treatments
- Acupuncture Treatment Research Studies
- Cancer Treatment and Pharmacology
- Medicinal Plant Pharmacodynamics Research
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Pharmacological Effects of Natural Compounds
- Cancer Diagnosis and Treatment
- Berberine and alkaloids research
- Lymphatic System and Diseases
- Cancer Mechanisms and Therapy
- Plant-based Medicinal Research
- Flavonoids in Medical Research
- Colorectal Cancer Treatments and Studies
- Liver physiology and pathology
- HER2/EGFR in Cancer Research
- Metastasis and carcinoma case studies
- Cancer-related molecular mechanisms research
- Medicinal Plants and Bioactive Compounds
- Inflammatory Biomarkers in Disease Prognosis
- Childhood Cancer Survivors' Quality of Life
Shanghai Changzheng Hospital
2025
Shaoxing People's Hospital
2024
Tianjin Nankai Hospital
2019-2024
Tianjin Medical University
2006-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Tianjin Hospital
2023
Hunan Provincial People's Hospital
2023
Hunan Normal University
2023
Nanchang University
2022
First Affiliated Hospital of Nanchang University
2022
Background The tumor microenvironment (TME) involves infiltration of multiple immune cell subsets, which could influence the prognosis and clinical characteristics. increasing evidence on role tumor-infiltrating lymphocytes (TILs) in primary metastatic melanomas supports that system is involved progression outcomes melanoma. However, landscape melanoma has not been systematically elucidated. Methods In this study, we used CIBERSORT ESTIMATE algorithms to analyze pattern 993 samples. Then...
Abstract Traditional Chinese medicine (TCM) has been used to treat tumors for years and demonstrated be effective. However, the underlying molecular mechanisms of herbs remain unclear. This study aims ascertain targets prolonging survival time patients with advanced hepatocellular carcinoma (HCC) based on network pharmacology, establish a research method accurate treatment TCM. The benefit TCM herbal (CHM) was proved by Kaplan–Meier Cox regression analysis among 288 patients. correlation...
<h3>Objective</h3> The study aimed to evaluate the prognostic value of pretreatment plasma dimerized plasmin fragment D (D-dimer), fibrinogen, and platelet levels in epithelial ovarian cancer (EOC) after adjusting for venous thromboembolism (VTE) screen out patients with greatest risk poor prognosis. <h3>Methods</h3> comprised 190 EOC. D-dimer, were examined before treatment analyzed patient clinicopathological parameters, progression-free survival (PFS), overall (OS). analysis was performed...
// Yu Mao 1, * , Jian Hao Zi-Qi Jin 2 Yang-Yang Niu 3 Xue Yang 1 Dan Liu Rui Cao 4 Xiong-Zhi Wu Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Prevention Therapy, Tianjin, 300060, China University, 300070, Children's 300134, Zhong-Shan-Men Inpatient Department, These authors have contributed equally to this study share first authorship Correspondence to: Wu, email: wuxiongzhi@163.com Keywords: metastatic breast...
Objective: To explore the risk factors associated with coronal imbalance following posterior short-level fixation and fusion surgery for patients degenerative lumbar scoliosis (DLS). Methods: A retrospective analysis was conducted on clinical data of who underwent treatment DLS at Shanghai Changzheng Hospital from January 2018 to December 2022. The postoperative follow-up period 12 months. Based distance between C7 plumb line central sacral vertical (C7-CSVL), were divided into an group...
Tumors recruit bone mesenchymal stem cells (BMSCs) to localize tumor sites, which induces their conversion into cancer-associated fibroblasts (CAFs) that facilitate progression. However, this process is poorly understood on the molecular level. In study, we found 4T1 breast cancer promoted migration of BMSCs, and bFGF neutralizing antibody inhibited BMSCs induced by a tumor-conditioned medium. addition, exogenous enhanced in dose-dependent manner vitro. Furthermore, proliferation under...
Some sulphated polysaccharides can bind bFGF but are unable to present its high-affinity receptors. Fucoidan, a polysaccharide purified from brown algae, which has been used as an anticancer drug in traditional Chinese medicine for hundreds of years, exhibits variety effects, including the induction apoptosis and autophagy cancer cells, inhibition growth angiogenesis, improvement antitumour immunity. Our research shows that fucoidan dose not inhibit expressions VEGF, bFGF, IL-8, heparanase...
Traditional Chinese medicine (TCM) is one of the most common complementary and alternative medicines used in treatment patients with cancer worldwide. However, clinical effect TCM on pancreatic remains unclear. This study was aimed to explore efficacy selected usefulness multimodality treatment, including western (WM), cancer.From January 2009 October 2013, 107 were included this study. Kaplan-Meier curves assess differences survival time. Cox regression analysis performed determine trends...
Abstract Increasing evidence has shown that Chinese herbal medicine (CHM) promising therapeutic effects in colorectal cancer (CRC); however, the active ingredients and potential targets remain unclear. In this study, we aimed to investigate relative molecular of herbs have been found effective treating metastatic CRC (mCRC) based on clinical data network pharmacology. multivariate analysis CHM resulted an independent prognostic factor. The hazard ratio was 0.103 (95% confidence interval =...
Abstract Transcriptomic deregulation by epigenetic mechanisms plays a crucial role in the heterogeneous progression of colorectal cancer (CRC). Herein, we first demonstrated that frequencies aberrancies DNA methylation-correlated (METcor) and microRNA (miRNA)-correlated (MIRcor) genes were significantly co-regulated. Next, through integrative clustering expression profiles METcor MIRcor genes, four molecular subtypes identified CRC patients from The Cancer Genome Atlas then validated...
Abstract Background The majority of patients may experience atelectasis under general anesthesia, and the Trendelenburg position pneumoperitoneum can aggravate during laparoscopic surgery, which promotes postoperative pulmonary complications. Lung recruitment manoeuvres have been proven to reduce perioperative atelectasis, but it remains controversial method is optimal. Ultrasonic imaging be conducive confirming effect lung manoeuvres. purpose our study was assess effects ultrasound-guided...
Increasing evidence has shown that Chinese Herbal Medicine (CHM) efficient therapeutic effects for advanced gastric adenocarcinoma, while the mechanisms underlying this treatment remain unclear. In study, Kaplan–Meier method and Cox regression analysis were used to evaluate survival benefit of CHM treatment, correlation was applied identify most effective components in formulas. A network pharmacological approach developed decipher potential CHM. an independent protective factor. The hazard...
Abstract Blockade of the epidermal growth factor receptor (EGFR) by EGFR tyrosine kinase inhibitors is insufficient for effective anti-tumor activity because reactivation ErbB3 signaling pathway significantly contributes to activating consequent phosphoinositide 3-kinase (PI3K)/Akt pathway. Combinatorial therapies including targeting may ameliorate tumor responses anti-EGFR therapies. In present study, we found that in BxPC-3 and L3.6pl cells, which highly expressed receptor, significant...
Background: Several studies indicated that the diagnosis season affects prognosis of some cancers, such as examples in prostate, colon and breast. This retrospective study aimed to investigate whether recurrent impacts epithelial ovarian cancer patients. Methods: From January 2005 August 2010, 161 patients were analyzed followed up until 2013. Kaplan-Meier survival curves log-rank test used make analysis. Multivariate analysis was conducted identify independent prognostic factors. Results:...
Background/Aims: The Xi-Huang (XH) formula has been used for breast cancer treatment in traditional Chinese medicine (TCM) since 1740. In this study, we show that, XH extract could suppress the growth of cells vitro and vivo, that it preferentially inhibits cell estrogen receptor positive (ER+) cells. Presently, little is known about potential mechanism our studies aim to elucidate its treatment. Methods: Network-based systems biology molecular docking analyses were performed predict...