A5068805735- HER2/EGFR in Cancer Research
- Medicinal Plant Extracts Effects
- Tryptophan and brain disorders
- Retinoids in leukemia and cellular processes
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Advanced Biosensing Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Manufacturing Process and Optimization
- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
- Pharmacological Effects of Natural Compounds
- Phagocytosis and Immune Regulation
- Advanced Breast Cancer Therapies
- Natural product bioactivities and synthesis
- Sarcoma Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Advanced machining processes and optimization
- Mechanical Engineering and Vibrations Research
- Pancreatic and Hepatic Oncology Research
- Phytochemistry and Bioactive Compounds
- Healthcare and Venom Research
- Computational Drug Discovery Methods
- Estrogen and related hormone effects
Beijing University of Chinese Medicine
2015-2023
Capital Medical University
2023
Tianjin Medical University Cancer Institute and Hospital
2006-2022
First Affiliated Hospital of Anhui Medical University
2022
Anhui Medical University
2022
Nanjing University of Chinese Medicine
2018-2022
Harbin Medical University
2010-2022
First Affiliated Hospital of Harbin Medical University
2010-2022
Jiangsu Province Hospital
2022
Peking University
2021
Abstract Traditional Chinese medicine (TCM) has been used to treat tumors for years and demonstrated be effective. However, the underlying molecular mechanisms of herbs remain unclear. This study aims ascertain targets prolonging survival time patients with advanced hepatocellular carcinoma (HCC) based on network pharmacology, establish a research method accurate treatment TCM. The benefit TCM herbal (CHM) was proved by Kaplan–Meier Cox regression analysis among 288 patients. correlation...
// Yu Mao 1, * , Jian Hao Zi-Qi Jin 2 Yang-Yang Niu 3 Xue Yang 1 Dan Liu Rui Cao 4 Xiong-Zhi Wu Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Prevention Therapy, Tianjin, 300060, China University, 300070, Children's 300134, Zhong-Shan-Men Inpatient Department, These authors have contributed equally to this study share first authorship Correspondence to: Wu, email: wuxiongzhi@163.com Keywords: metastatic breast...
Parkinson's disease (PD) is the second most common neurodegenerative worldwide. Nootkatone (NKT) has been shown to have neuroprotective, anti-inflammatory, and antioxidant effects in this study, we systematically studied efficacy mechanism of action NKT rotenone (ROT)-induced PD rats. Firstly, through behavioral experiments brain tissue staining, found that alleviated dysfunction protected dopaminergic neurons associated with ROT-induced Next, target prediction, protein-protein interaction...
Abstract : Chondrocyte maturation during endochondral bone formation is regulated by a number of signals that either promote or inhibit maturation. Among these, two well‐studied signaling pathways play crucial roles in modulating chondrocyte maturation: transforming growth factor‐beta (TGF‐β)/Smad3 slows the rate maturation, while Wingless/INT‐1‐related (Wnt)/β‐catenin enhances Axin1 and Axin2 are functionally equivalent have been shown to Wnt/β‐catenin stimulate TGF‐β signaling. Here we...
Tumors recruit bone mesenchymal stem cells (BMSCs) to localize tumor sites, which induces their conversion into cancer-associated fibroblasts (CAFs) that facilitate progression. However, this process is poorly understood on the molecular level. In study, we found 4T1 breast cancer promoted migration of BMSCs, and bFGF neutralizing antibody inhibited BMSCs induced by a tumor-conditioned medium. addition, exogenous enhanced in dose-dependent manner vitro. Furthermore, proliferation under...
Background: Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignant tumors head and neck, it has shown increasing incidence mortality.The mechanistic target rapamycin complex 1 (mTORC1) frequently dysregulated in LSCC, but its underlying mechanisms remain unclear.Methods: Establishment a novel LSCC line using primary tumor tissues with mTORC1 activity then stable knockdown Raptor (an specific component) this line.Transcriptomic sequencing, quantitative real-time PCR,...
Traditional Chinese medicine (TCM) is one of the most common complementary and alternative medicines used in treatment patients with cancer worldwide. However, clinical effect TCM on pancreatic remains unclear. This study was aimed to explore efficacy selected usefulness multimodality treatment, including western (WM), cancer.From January 2009 October 2013, 107 were included this study. Kaplan-Meier curves assess differences survival time. Cox regression analysis performed determine trends...
The methylated septin 9 (mSEPT9) assay was the first blood-based test approved by United States Food and Drug Administration as a colorectal screening test. However, diagnostic prognostic role of preoperative mSEPT9 for cancer (CRC) in Chinese patients is still unknown.To improve understanding factors, serum detected CRC patients.A retrospective analysis 354 cases, which 300 had 54 were normal, performed China. Patients' characteristics, treatments, laboratory data, including age, date...
Abstract Axis inhibition proteins 1 and 2 (Axin1 Axin2) are scaffolding that modulate at least two signaling pathways crucial in skeletogenesis: the Wnt/β‐catenin TGF‐β pathways. To determine whether Axin2 is important skeletogenesis, we examined skeletal phenotype of Axin2‐null mice a wild‐type or Axin1 +/− background. Animals with disrupted expression displayed runt when compared to heterozygous littermates. Whole‐mount tissue β‐galactosidase staining LacZ/LacZ revealed expressed cartilage...
Levodopa combined with traditional Chinese medicine has a synergistic effect on Parkinson's disease (PD). Recently, we demonstrated that Nardostachys jatamansi (D. Don) DC. [syn. Patrinia D.Don, N. grandiflora DC.] (Valerianaceae) (NJ) can alleviate PD.To explore the of NJ levodopa against PD.The PD model was established by injecting rotenone. Eighty-four Sprague-Dawley rats were randomly divided into seven groups: sham, model, different doses (0.31, 0.62, or 1.24 g/kg) (25 mg/kg), and alone...
Increasing evidence has shown that Chinese Herbal Medicine (CHM) efficient therapeutic effects for advanced gastric adenocarcinoma, while the mechanisms underlying this treatment remain unclear. In study, Kaplan–Meier method and Cox regression analysis were used to evaluate survival benefit of CHM treatment, correlation was applied identify most effective components in formulas. A network pharmacological approach developed decipher potential CHM. an independent protective factor. The hazard...
Abstract Blockade of the epidermal growth factor receptor (EGFR) by EGFR tyrosine kinase inhibitors is insufficient for effective anti-tumor activity because reactivation ErbB3 signaling pathway significantly contributes to activating consequent phosphoinositide 3-kinase (PI3K)/Akt pathway. Combinatorial therapies including targeting may ameliorate tumor responses anti-EGFR therapies. In present study, we found that in BxPC-3 and L3.6pl cells, which highly expressed receptor, significant...
Abstract Anxiety disorder is a chronic and disabling psychiatric that more prevalent in females than males. 11‐Ethoxyviburtinal an iridoid extracted from Valeriana jatamansi Jones , which has anxiolytic potential. The aim of the present work was to study efficacy mechanism 11‐ethoxyviburtinal gender‐specific mice. We first evaluated anxiolytic‐like restraint stress (CRS) mice different sexes through behavioral experiments biochemical indexes. In addition, network pharmacology molecular...
Arsenic trioxide (ATO) is a classic apoptosis-inducing agent used to treat acute promyelocytic leukemia. However, the therapeutic effect of ATO limited in lymphoma, which resists apoptosis possibly due inappropriate activation STAT3. Therefore, combination and STAT3 inhibitor may be potential strategy lymphoma. Dramatically, Cucurbitacin B (CuB), an effective component dichloromethane extraction from Trichosanthes kirilowii Maxim, synergistically eliminated resistance Burkitt’s lymphoma...
Human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC) accounts for about 20% to 30% of all BC subtypes and is characterized by invasive disease poor prognosis. With the emergence anti-HER2 target drugs, HER2-positive patient outcomes have changed dramatically. However, treatment failure mostly due drug resistance special needs different subgroups. Small molecule tyrosine kinase inhibitors can inhibit multiple targets human family activate PI3K/AKT, MAPK, PLC γ, ERK1/2,...
The objective of this study is to investigate pharmacokinetics gelatin sponge microparticles (GSMs) combined with epirubicin in a rabbit VX2 liver tumor model hepatic arterial chemoembolization (TACE). Eighteen successful models New Zealand white rabbits was established, which were divided into three groups randomly: HAI group (n = 6), the solution (epirubicin 10 mg mixed saline ml artery); GSMs-TACE GSMs (20 mg) (1 mg/ml); c-TACE (10 lipiodol ml). Each administrated at dose adjusted for 1...
An ultrasound-assisted micro-injection molding method is proposed to improve the rheological behavior of polymer melt radically, and a system based on longitudinal ultrasonic vibration core developed employed in process Fresnel lenses. The verification experiments show that filling mold area increased by 6.08% 19.12%, symmetric deviation lens improved 15.62% average. This performance replication quality injection effectively.
Both the DNA damage response (DDR) and mitotic checkpoint are critical for maintenance of genomic stability. Among proteins involved in these processes, ataxia-telangiectasia mutated (ATM) kinase is required both activation DDR spindle assembly (SAC). In mitosis without damage, enzymatic activity ATM enhanced; however, substrates unknown. Using stable isotope labeling amino acids cell culture mass spectrometry analysis, we identified a number that can potentially be phosphorylated by during...
Background/Aims: The Xi-Huang (XH) formula has been used for breast cancer treatment in traditional Chinese medicine (TCM) since 1740. In this study, we show that, XH extract could suppress the growth of cells vitro and vivo, that it preferentially inhibits cell estrogen receptor positive (ER+) cells. Presently, little is known about potential mechanism our studies aim to elucidate its treatment. Methods: Network-based systems biology molecular docking analyses were performed predict...
In a rotenone-induced Parkinson's disease (PD) rat model, behavioral investigation, pathological examination, inflammatory factor analysis, and mitochondrial structure function investigation verified the anti-PD efficacy of nardosinone. A combined transcriptome proteome analysis proposed that target nardosinone is slc38a2 gene may involve GABAergic synaptic pathway cAMP-signaling pathway. Analysis targeted knockout cells expression key enzyme-encoding genes in both pathways by 'omics...
Insomnia is a common and widespread sleeping disorder caused by various risk factors. Though beneficial, conventional treatments of insomnia have significant limitations. As an alternative treatment, Chinese herbal formula Suanzaoren prescription (SZRP), composed (seeds Ziziphus jujuba var. spinosa (Bunge) Hu ex H.F.Chow) four additional herbs, has been reported with anti-insomnia effects. Yet the mechanism herb formulae remains unknown. In this study, we attempted to extrapolate holistic...
Objective: Head and neck squamous cell carcinoma (HNSCC) is a common heterogeneous cancer with complex carcinogenic factors. However, the current TNM staging criteria to judge its severity formulate treatment plans evaluate prognosis are particularly weak. Therefore, robust diagnostic model capable of accurately diagnosing predicting HNSCC should be established. Methods: Gene expression clinical data were retrieved from The Cancer Genome Atlas Expression Omnibus databases. Key prognostic...
Abstract: Self-assembling peptides are capable of forming a complex containing cavity where cytotoxic agents can be wrapped in self-assembling manner. These complexes beneficial for improving the pharmacological properties and pharmacokinetics agents, such as doxorubicin paclitaxel. In present study, this feature was successfully integrated into hexapeptide with matrix metalloproteinase (MMP)-2 specific targeting activity, producing supramolecule possessing controlled drug release...