A5101831379- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- interferon and immune responses
- Glioma Diagnosis and Treatment
- Chromatin Remodeling and Cancer
- Cancer Cells and Metastasis
- Natural Antidiabetic Agents Studies
- Ubiquitin and proteasome pathways
- TGF-β signaling in diseases
- Steroid Chemistry and Biochemistry
- Mechanisms of cancer metastasis
- Iterative Learning Control Systems
- Mitochondrial Function and Pathology
- Nanoparticle-Based Drug Delivery
- ATP Synthase and ATPases Research
- Ferroptosis and cancer prognosis
- Genomics and Chromatin Dynamics
- Extracellular vesicles in disease
- Advanced MRI Techniques and Applications
- Biochemical Analysis and Sensing Techniques
- Peptidase Inhibition and Analysis
Tianjin Medical University General Hospital
2017-2025
Ministry of Education of the People's Republic of China
2017-2023
Tianjin Medical University
2014-2018
Tianjin People's Hospital
2018
American Journal Experts (United States)
2018
Abnormal alternative splicing (AS) caused by alterations to factors contributes tumor progression. Serine/arginine factor 1 (SRSF1) has emerged as a key oncodriver in numerous solid tumors, leaving its roles and mechanisms largely obscure glioma. Here, we demonstrate that SRSF1 is increased glioma tissues cell lines. Moreover, expression was correlated positively with grade Ki-67 index, but inversely patient survival. Using RNA-Seq, comprehensively screened identified multiple SRSF1-affected...
The lethality and poor outcome of high-grade gliomas result from the tumour relentless invasion. miR-29a/b/c downexpressions contribute to several human tumourigenesis. However, their relevance prognosis invasion in remains unclear. Relationships CDC42 expressions grade survival-time 147 were analysed by situ hybridisation immunohistochemistry. Dual-luciferase reporter assay was used identify as a target miR-29a/b/c. Underlining mechanisms which inhibited glioma cell migration studied vitro...
Glioma is a common brain tumour that associated with poor prognosis. Immunotherapy has shown significant potential in the treatment of gliomas. Herein, we proposed new prognostic risk model based on immune- and mitochondrial energy metabolism-related differentially expressed genes (IR&MEMRDEGs) to enhance accuracy assessment patients glioma. Data from samples 671 glioma 5 normal controls available follow-up data outcomes were downloaded Gene Expression Omnibus (GEO) The Cancer Genome Atlas...
Improving glioma treatment effectiveness requires a thorough understanding of gliomagenesis. Emerging evidences have proved that zinc and ring finger 2 (ZNRF2) contributes to development various human malignancies. Nevertheless, comprehensive study ZNRF2's role in is absent currently. Utilizing open resources from Chinese Glioma Genome Atlas (CGGA), Gene Expression Omnibus (GEO), The Cancer (TCGA), Connectivity Map (cMap) other bioinformatic tools, we systematically examined the expression,...
miR-320a downexpression contributes to tumorigenesis in several human cancers. However, the relevance of prognosis, proliferation and invasion gliomas remains unclear. In this study, we demonstrated that expression was decreased glioma tissues cell lines. Moreover, inversely correlated with grades Ki-67 index, but positively patients' survival. Contrarily, SND1 β-catenin expressions were Furthermore, two subgroups distinct prognoses our patients different grade, IDH status, age KPS...
In order to solve the problems of receptor promiscuity and poor blood-brain barrier (BBB) penetration in treatment glioblastomas (GBM), a novel dual-functional nanocomplex drug delivery system is developed based on strategy peptide-drug conjugates. this study, SynB3-PVGLIG-PTX designed screened out by matrix metalloproteinase-2 (MMP-2), which it exhibits best affinity. The MMP-2-sensitive peptide (PVGLIG) cell-penetration (SynB3) are combined form peptide. Moreover, as drug-peptide...
Quaking-5 (QKI-5) belongs to the STAR (signal transduction and activation of RNA) family RNA binding proteins functions as a tumor suppressor in several human malignancies. In this study, we attempt elucidate role QKI-5 pro-metastasis processes lung cancer (LC) cells underlying mechanisms. We confirmed that was decreased LC tissues cell lines, especially high-metastatic cells. Moreover, QKI expression positively correlated with patients' survival. Functional studies verified suppressed...
Upregulation of staphylococcal nuclease domain-containing protein 1 (SND1) is a common phenomenon in different human malignant tissues. However, little information available on the underlying mechanisms through which SND1 affects glioma cell proliferation and invasion.SND1, Ras homolog family member A (RhoA), marker Ki-67 (MKI67) were analyzed 187 gliomas by immunostaining. The correlation between those markers patients' prognoses was assessed using Kaplan-Meier estimator. Gene Ontology,...
Background: Downregulation of miR-361-5p contributes to epithelial–mesenchymal transition glioma cells. However, the relevance migration and invasion gliomas remains unknown. Materials methods: The relationship between SND1 expression was analyzed in 120 human 8 cell lines by situ hybridization, immunohistochemistry, Western blot. Dual-luciferase reporter assay used identify as a target miR-361-5p. mechanisms through which inhibits were studied vitro assays. Results: significantly...
Robust proliferation and apoptosis inhibition of tumor cells are responsible for the high mortality poor outcome patients with high-grade gliomas. miR-29a/b/c have been reported to be important suppressors in several human types. However, their exact roles gliomagenesis relevance patient prognosis remain unclear. In this study, using 187 glioma specimens 20 nontumoral brain tissues, we demonstrated that expression decreased progressively as grade Ki-67 index increased. TRAF4, functional...
Abstract Pontin (RUVBL1) is a highly conserved ATPase of the AAA + (ATPases Associated with various cellular Activities) superfamily and implicated in biological processes crucial for oncogenesis. Its overexpression observed multiple human cancers, whereas relevance to gliomagenesis remains obscure. To gain insights into involvement glioma, we performed bioinformatics analyses co-expressed genes, Pontin-affected carried out experimental studies. The results verified that was upregulated...
Abstract: Self-assembling peptides are capable of forming a complex containing cavity where cytotoxic agents can be wrapped in self-assembling manner. These complexes beneficial for improving the pharmacological properties and pharmacokinetics agents, such as doxorubicin paclitaxel. In present study, this feature was successfully integrated into hexapeptide with matrix metalloproteinase (MMP)-2 specific targeting activity, producing supramolecule possessing controlled drug release...
Emerging evidence has shown that miR-29 is a promising biomarker and therapeutic target for malignancies. The roles of miR-29a/b/c in glioma pathogenesis remain need further investigation.The expression levels CDC42 were systematically analysed, prognostic significance was evaluated by Kaplan-Meier survival Cox regression analyses. apoptosis the underlying mechanisms explored via an alkaline single-cell gel electrophoresis assay, caspase 3/7 activity assays Western blotting.miR-29a/b/c...
The α-glycosidase inhibition assay is used to examine the activity of traditional Chinese medicines through extraction with methanol. isolated compounds measured by and compared Acarbose. Molecular docking implemented study interaction between CtMGAM (maltase–glucoamylase-C) or NtMGAM (maltase–glucoamylase-N). Compared those Acarbose, methanol extract Gardenia jasminoides Ellis has a higher inhibit among 74 medicines. Geniposide Gardenoside, from Ellis, have better (IC50 values 0.35 0.46...
Abstract Synergies of transcription factors, chromatin modifiers and their target genes are vital for cell fate determination in human cancer. Although the importance numerous epigenetic machinery regulating gliomagenesis has been previously recognized, how collaborate with specific factors remains largely elusive. Herein we report that Pontin remodelling factor acts as a coactivator LEF1 to activate TGFβ/SMAD signalling, thereby contributing gliomagenesis. is highly expressed gliomas, its...
To investigate the effect of serine/arginine-rich splicing factor 2 (SRSF2) on ferroptosis and its possible mechanism in glioblastoma cells.